The Cell Cycle: Principles of Control (Primers in Biology) (Primers in Biology)

Cell division is a central biological process: it yields the cells required for development and growth, and supplies the replacement cells to repair and maintain old or damaged tissue. This book provides an overview of the process of cell division - from chromosome division, through mitosis, cytokinesis, and meiosis. 1. The cell cycle -- 2. Model organisms in cell-cycle analysis -- 3. The cell-cycle control system -- 4. Chromosome duplication -- 5. Early mitosis : preparing the chromosomes for segregation -- 6. Assembly of the mitotic spindle -- 7. The completion of mitosis -- 8. Cytokinesis -- 9. Meiosis -- 10. Control of cell proliferation and growth -- 11. The DNA damage response -- 12. The cell cycle in cancer The Cell Cycle is an account of the mechanisms that control cell division, beginning with a description of the phases and main events of the cell cycle and the main model organisms in cell-cycle analysis, including Xenopus, Drosophila, and yeasts. Later chapters focus on the molecules and mechanisms of the cell-cycle control system, including the cyclin-dependent kinase family of protein kinases, the cyclins that activate them, and the signaling molecules that regulate them, and discuss cell-cycle control in development and the failure of controls in cancer. Cell division is a central biological process: it yields the cells required for development and growth, and supplies the replacement cells to repair and maintain old or damaged tissue. This book gives the students a complete overview of the process of cell division - from chromosome division, through mitosis, cytokinesis, and meiosis. The Cell Cycle: Principles of Control provides an engaging insight into the process of cell division, bringing to the student a much-needed synthesis of a subject entering a period of unprecedented growth as an understanding of the molecular mechanisms underlying cell division are revealed