The Carcinogenicity of Metals: Human Risk Through Occupational and Environmental Exposure (Issues in Toxicology, Volume 18)

This book re-evaluates epidemiological and occupational health studies, experimental studies in animals and in vitro experiments relating to the toxicity of 27 metal and metalloid elements for which evidence of carcinogenicity has been presented. Human carcinogenic risk is substantiated in relation to arsenic, beryllium, thorium, chromium, radioactive elements, probably lead, and some nickel and cobalt compounds, and respirable silica particles, but the carcinogenicity of iron, aluminium, titanium, tungsten, antimony, bismuth, mercury, precious metals, and certain related compounds in humans is unresolved. The toxicity and carcinogenicity of each element is specific but correlates poorly with its position in the Periodic Table. Carcinogenicity differs according to the valency of the ion and its ability to interact with and penetrate membranes in target cells and to bind, denature or induce mutations by genotoxic or epigenetic mechanisms. This important text comprehensively examines each of the elements providing detailed information on the carcinogenicity and toxicity and detailing the most up-to-date research in this area. The book will be an essential tool for toxicologists, medicinal and biochemists, and environmental scientists working in both industry and academia. This book re-evaluates epidemiological and occupational health studies, experimental studies in animals and in vitro experiments relating to the toxicity of 27 metal and metalloid elements for which evidence of carcinogenicity has been presented. Human carcinogenic risk is substantiated in relation to arsenic, beryllium, thorium, chromium, radioactive elements, probably lead, and some nickel and cobalt compounds, and respirable silica particles, but the carcinogenicity of iron, aluminium, titanium, tungsten, antimony, bismuth, mercury, precious metals, and certain related compounds in humans is unresolved. The toxicity and carcinogenicity of each element is specific but correlates poorly with its position in the Periodic Table. Carcinogenicity differs according to the valency of the ion and its ability to interact with and penetrate membranes in target cells and to bind, denature or induce mutations by genotoxic or epigenetic mechanisms. This important text comprehensively examines each of the elements providing detailed information on the carcinogenicity and toxicity and detailing the most up-to-date research in this area. The book is an essential tool for toxicologists, medicinal and biochemists, and environmental scientists working in both industry and academia fig2......Page 20 fig3......Page 21 fig1......Page 40 fig2......Page 44 fig3......Page 48 fig1......Page 58 fig2......Page 60 fig1......Page 74 fig1......Page 96 fig2......Page 97 fig1......Page 127 fig2......Page 142 fig3......Page 144 fig4......Page 146 fig1......Page 195 fig2......Page 198 fig3......Page 199 fig4......Page 201 fig5......Page 203 fig1......Page 223 fig2......Page 227 fig1......Page 244 fig1......Page 270 fig2......Page 277 fig1......Page 310 fig1......Page 338 fig1......Page 350 fig2......Page 355 fig1......Page 368 fig2......Page 372 fig3......Page 374 fig4......Page 376 This important text comprehensively examines each of the elements for which carcinogenicity has been established, providing detailed information on the carcinogenicity and toxicity and detailing the most up-to-date research in this area. Alan B. G. Lansdown. Includes Bibliographical References And Index. Mode Of Access: World Wide Web.