The Carbonic Anhydrases as Biocatalysts : from theory to medical and industrial applications

Carbonic anhydrases (CAs, EC 4.2.1.1) are ubiquitous metalloenzymes, present throughout most living organisms and encoded by five evolutionarily unrelated gene families. The Carbonic Anhydrases as Biocatalysts: From Theory to Medical and Industrial Applications presents information on the growing interest in the study of this enzyme family and their applications to both medicine and biotechnology. Offers comprehensive coverage of the carbonic anhydrases enzyme family and their properties as biocatalysts Includes current applications of carbonic anhydrases in biotechnology on the basis of their catalytic efficiency, including new technologies for CO 2 capture processes Identifies new targets for drug design studies Provides a selectivity profile for the different carbonic anhydrases and their related biomedical applications Content: Front matter, Page iii Copyright, Page iv List of Contributors, Pages xi-xiii, Atilla Akdemir, Vincenzo Alterio, Ashok Aspatwar, Harlan Barker, Mathieu Beauchemin, Christopher D. Boone, Roberta Cadoni, Clemente Capasso, Pedro Colinas, Katia D’Ambrosio, Giuseppina De Simone, Michaela Debreova, James G. Ferry, Anna Di Fiore, Özlen Güzel-Akdemir, Jukka Leinonen, Brian P. Mahon, Robert McKenna, Simona M. Monti, David Morse, Elena Ondriskova, et al. Preface, Pages xv-xvi, Giuseppina De Simone, Claudiu T. Supuran Chapter 1 - Carbonic Anhydrases: An Overview, Pages 3-13, Claudiu T. Supuran, Giuseppina De Simone Chapter 2 - Human Carbonic Anhydrases: Catalytic Properties, Structural Features, and Tissue Distribution, Pages 17-30, Katia D’Ambrosio, Giuseppina De Simone, Claudiu T. Supuran Chapter 3 - Carbonic Anhydrase I, Pages 31-49, Nicolino Pala, Roberta Cadoni, Mario Sechi Chapter 4 - Carbonic Anhydrase II as Target for Drug Design, Pages 51-90, Claudiu T. Supuran, Clemente Capasso, Giuseppina De Simone Chapter 5 - Carbonic Anhydrase III, Pages 91-108, Brian P. Mahon, Robert McKenna Chapter 6 - Carbonic Anhydrase IV, Pages 109-124, Abdul Waheed, William S. Sly Chapter 7 - The Structure, Physiological Role, and Potential Medicinal Applications of Carbonic Anhydrase V, Pages 125-138, Atilla Akdemir, Özlen Güzel-Akdemir Chapter 8 - Secreted Carbonic Anhydrase Isoenzyme VI, Pages 139-149, Jukka Leinonen, Seppo Parkkila Chapter 9 - Carbonic Anhydrase VII, Pages 151-168, Simona M. Monti, Claudiu T. Supuran, Giuseppina De Simone, Anna Di Fiore Chapter 10 - Tumor-Associated Carbonic Anhydrases IX and XII, Pages 169-205, Elena Ondriskova, Michaela Debreova, Silvia Pastorekova Chapter 11 - Carbonic Anhydrase XIII, Pages 207-219, Ashok Aspatwar, Martti E.E. Tolvanen, Harlan Barker, Seppo Parkkila Chapter 12 - Carbonic Anhydrase XIV: Structure, Functions, and Potential Medical Applications, Pages 221-237, Jean-Yves Winum Chapter 13 - Acatalytic Carbonic Anhydrases (CAs VIII, X, XI), Pages 239-245, Claudiu T. Supuran, Clemente Capasso Chapter 14 - β-Carbonic Anhydrases: General Features and Medical Implications, Pages 247-273, Margaret M. Suhanovsky, Kelly Sheppard, Roger S. Rowlett Chapter 15 - Bacterial Carbonic Anhydrases as Drug Targets, Pages 275-288, Clemente Capasso, Claudiu T. Supuran Chapter 16 - Engineered Mammalian Carbonic Anhydrases for CO2 Capture, Pages 291-309, Christopher D. Boone, Robert McKenna Chapter 17 - Carbonic Anhydrases From Extremophiles and Their Biotechnological Applications, Pages 311-324, Clemente Capasso, Claudiu T. Supuran Chapter 18 - Carbonic Anhydrases of Environmentally and Medically Relevant Anaerobic Prokaryotes, Pages 325-336, James G. Ferry Chapter 19 - δ-Carbonic Anhydrases: Structure, Distribution, and Potential Roles, Pages 337-349, Mathieu Beauchemin, David Morse Chapter 20 - CDCA1 From Thalassiosira weissflogii as Representative Member of ζ-Class CAs: General Features and Biotechnological Applications, Pages 351-359, Simona M. Monti, Giuseppina De Simone, Claudiu T. Supuran, Vincenzo Alterio Chapter 21 - Carbonic Anhydrases as Esterases and Their Biotechnological Applications, Pages 361-371, Jean-Yves Winum, Pedro Colinas Index, Pages 373-381

Carbonic anhydrases (CAs, EC 4.2.1.1) are ubiquitous metalloenzymes, present throughout most living organisms and encoded by five evolutionarily unrelated gene families. The Carbonic Anhydrases as Biocatalysts: From Theory to Medical and Industrial Applications presents information on the growing interest in the study of this enzyme family and their applications to both medicine and biotechnology.

• Offers comprehensive coverage of the carbonic anhydrases enzyme family and their properties as biocatalysts
• Includes current applications of carbonic anhydrases in biotechnology on the basis of their catalytic efficiency, including new technologies for CO2 capture processes
• Identifies new targets for drug design studies
• Provides a selectivity profile for the different carbonic anhydrases and their related biomedical applications

Carbonic anhydrases (CAs, EC 4.2.1.1) are ubiquitous metalloenzymes, present throughout most living organisms and encoded by five evolutionarily unrelated gene families. __The Carbonic Anhydrases as Biocatalysts:____From Theory to Medical and Industrial Applications__ presents information on the growing interest in the study of this enzyme family and their applications to both medicine and biotechnology.