The Biology of the Interferon System 1986 : Proceedings of the 1986 ISIR-TNO Meeting on the Interferon System, 7–12 September 1986, Dipoli Congress Center, Espoo, Finland

Front Matter....Pages I-XII Front Matter....Pages 1-1 Amino Acid Residues Affecting Antiviral and Antiproliferative Activity in Interferon-α’s....Pages 3-9 Differential Structures and Activities of Three IFN α 2 Variants Departing Only at Two Amino Acid Positions....Pages 11-18 Selective Association of High Density Lipoprotein with Interferon Beta Serine....Pages 19-23 Structure, Genetics and Function of Human β 2 Interferon....Pages 25-30 Tailoring of Alpha Interferons Via In Vivo Recombination of the Genes....Pages 31-36 A New Type of Interferon-Like Protein Produced by Peripheral Blood Mononuclear Cells Treated with Inhibitors of Transcription....Pages 37-43 Apparent Auto-Inhibition of Murine Interferon-γ Due to a Serum Component....Pages 45-50 Front Matter....Pages 51-51 Nuclear Localization of Internalized Interferons-β and -γ: A Role for Nuclear Receptors....Pages 53-56 The 5′ End of the Human (2′–5′) Oligo a Synthetase Gene Contains Sequences Responsible for Transcriptional Activation by Interferon....Pages 57-63 Expression and Preliminary Deletion Analysis of the 42 kDa 2–5A Synthetase Induced By Human Interferon....Pages 65-72 The Double-Stranded RNA Dependent Protein Kinase from Human Cells....Pages 73-77 Homologs to Mouse Mx Protein Induced by Interferon in Various Species....Pages 79-84 Comparative Studies of the Genomic Structure of Two Human Interferon Induced Genes....Pages 85-91 Characterization of Two New IFN-Induced Proteins....Pages 93-98 Early Events in the Interaction of IFN-α with IFN-Sensitive and IFN-Resistant Daudi Cells....Pages 99-105 Front Matter....Pages 107-107 Some Freshly EBV-Transformed B-Cell Lines Lack Functional IFN-Receptors....Pages 109-115 Production of Antibodies Against the Murine IFN-γ Receptor....Pages 117-120 Purification and Characterization of the Receptor for Human Interferon-γ....Pages 121-128 Front Matter....Pages 129-129 Interferon Induction by Transfection of Sendai Virus C Gene cDNA....Pages 131-138 Studies on the Expression of Spontaneous Interferon-Like Activity in Mouse Peritoneal Cells....Pages 139-146 Front Matter....Pages 129-129 Cellular Factors Mediate Induction and Superinduction of the Human Interferon-β Gene....Pages 147-152 Interferon Beta-2 is Constitutively Expressed in Human Monocytes....Pages 153-158 Regulation of Human Fibroblast Growth by Autocrine Interferon-Beta....Pages 159-163 Biological Activities of Human Interferon-β 2 Produced by cDNA Expression in Hamster Cells and Possible Autocrine Functions of this Cytokine-Induced IFN....Pages 165-171 Front Matter....Pages 173-173 Overview of Long-Term IFN Effects on the Phenotype of Transformed and Tumor Cells....Pages 175-182 Mechanisms for Anti-Invasive Effect of Interferon....Pages 183-190 Comparison of Different Modes of Interferon Delivery by Tumor Specific Monoclonal Antibodies....Pages 191-196 Characterization of Rat Monoclonal Antibodies to Mouse Interferon-α and -β....Pages 197-201 Front Matter....Pages 203-203 Molecular and Cellular Biology of Tumor Necrosis Factor, Interferon-γ, and their Synergism....Pages 205-216 Induction of 26kDa Protein mRNA in Human Cells Treated with Recombinant Human Tumour Necrosis Factor (rTNF)....Pages 217-222 Interactions of Tumor Necrosis Factor, Interferon and Interleukin-1 in Cell Killing....Pages 223-230 New Relationships Among IFN-Gamma, TNF and IL-1: Cellular and Biochemical Effects....Pages 231-235 Antagonistic Effect of Type I Interferons on Human Macrophage Activation by Interferon-γ....Pages 237-241 Gamma-Interferon Regulates Secretion of G-CSF in Human Monocytes on the Transcriptional Level....Pages 243-250 Presence of Tumor Necrosis Factor and Lymphotoxin in Clinical Interferon Preparations Derived from Leukocytes....Pages 251-256 Phenotype of γ-Interferon Producing Leukocytes....Pages 257-263 Interferon Regulates Major Histocompatibility Class I Gene Expression through a 5′ Upstream Regulatory Region....Pages 265-271 The Antiviral Effects of Tumor Necrosis Factors....Pages 273-277 Front Matter....Pages 279-279 Interferon and Tumor Necrosis Factor Alter the Phospholipid Metabolism in Friend Leukemia Cell Tumors in Mice....Pages 281-285 Antitumor Effects of Rat Rec.Ifn-γ in Rats Bearing Transplantable Rat Tumors....Pages 287-292 Front Matter....Pages 279-279 Mechanisms of Anticancer Action of Interferons on Human Tumour Xenografts in Nude Mice....Pages 293-300 IFN-Gamma Inhibits Osteosarcoma Xenografts in Nude Mice....Pages 301-304 Transgenic Mice Carrying Exogenous Mouse Interferon Genes....Pages 305-311 Studies on Interferon in the Bovine Species: Biological and Biochemical Effects....Pages 313-323 Front Matter....Pages 325-325 Treatment of Malignant Endocrine Pancreatic Tumors with Human Leukocyte Interferon....Pages 327-335 Efficacy of Alpha Interferons in Hairy Cell Leukemia (HCL) and Status of the Interferon System of Patients in Remission....Pages 337-342 Wellferon R Efficacy in the Treatment of Hairy Cell Leukaemia (HCL)....Pages 343-348 Detection of Urinary Enzyme Excretion as a Parameter of the Nephrotoxicity of Human Interferon Alpha-2b in Patients with Hairy Cell Leukemia (HCL)....Pages 349-354 Interferon Alfa-N1 Wellferon R in Kaposi’s Sarcoma: Single Agent or Combination with Vinblastine....Pages 355-362 Combined Interferon-Polychemotherapy versus Polychemotherapy in Multiple Myeloma: A Phase-III Study....Pages 363-370 Recombinant Interferon Alpha (2A) Combined with Dacarbazine in Treatment of Metastatic Melanoma....Pages 371-377 Intralesional Interferon-Alpha-Therapy in Advanced Malignant Melanoma....Pages 379-385 Comparison of Clinical Toxicity of Natural Alpha and Recombinant Gamma Interferon. Results of Phase II Trials in Lung Cancer....Pages 387-397 Antitumor Activity of Interferon- β Against Malignant Glioma in Combination with Chemotherapeutic Agent of Nitrosourea(ACNU)....Pages 399-406 Interferon Alpha in the Treatment of Malignant Diseases: Sources, Doses, and Regimens....Pages 407-414 Treatment of Various Malignancies with Recombinant IFN-γ....Pages 415-421 Interferons and Interferon Inactivators in Aids, Arc and in Cancer Patients....Pages 423-427 Overview:Clinical Trial with Natural and Recombinant Interferons in China....Pages 429-433 Interferon Producing Capacity in Patients with Liver Disease, Diabetes Mellitus, Chronic Diseases and Malignant Diseases....Pages 435-441 Early Treatment of the Common Cold with Intranasal Interferon Alpha-2a (Ro 22–8181): A Preliminary Pilot Study....Pages 443-448 Front Matter....Pages 325-325 Long-Term Tolerance of Intranasal Recombinant Interferon-β SER in Man....Pages 449-456 The Role of Alpha 2 Interferon in Combination with Acyclovir in Ophthalmic Zoster (an open pilot study)....Pages 457-462 Production of a Partially Acid Labile Alpha Interferon in Cytomegalovirus Pneumonitis....Pages 463-468 Randomized Controlled Trial of a Four Month Course of Recombinant Human Alpha Interferon in Patients with Chronic Type B Hepatitis....Pages 469-475 Treatment of Chronic Hepatitis B Infection with Alpha (Lymphoblastoid) Interferon: Responses in Different Social And Ethnic Groups in Comparision to Adenine Arabinoside Monophosphate....Pages 477-484 Interferon Alfa-n1 (Wellferon) ® in Severe Recurrent Genital Warts: Report of a Multi-Study Program....Pages 485-491 Activity of Intralesional Interferon Alfa-2b in Viral and Malignant Skin Diseases....Pages 493-501 Idiopathic Mixed Cryoglobulinemia: A New Therapeutic Approach with Alpha Interferon....Pages 503-510 Treatment of Rheumatoid Arthritis (RA) with Interferon-Gamma (IFN-gamma): Results of Clinical Trials in Germany....Pages 511-518 Interferon in Human Breast Cystic Disease....Pages 519-523 Efficacy of Intrathecally Administered Natural Human Fibroblast Interferon as Treatment of Multiple Sclerosis....Pages 525-529 A Study on the Efficacy of Recombinant HumanαD Type Interferon (rIFN-αD) in Treatment of Chronic Cervicitis....Pages 531-536 Presence and Possible Role of Interferons in Psoriasis....Pages 537-542 The Components of the Interferon System in SLE and Psoriasis....Pages 543-548 Pharmacokinetics of [ 123 I]-Interferon (IFN) Alpha-A....Pages 549-556 2′5′ A Synthetase Activity is Induced by a Factor Excreted in Heat-Shocked Cells. Comparison of this Factor with IFN....Pages 557-562 Mapping the Action of Interferon on Primate Brain....Pages 563-566 Chemical and Biological Characterization of Natural Human Lymphoblastoid Interferon Alphas....Pages 567-569 Back Matter....Pages 571-579