The Biological Chemistry of Iron : A Look at the Metabolism of Iron and Its Subsequent Uses in Living Organisms Proceedings of the NATO Advanced Study Institute Held at Edmonton, Alberta, Canada, August 13 – September 4, 1981

The results of a NATO Advanced Study Institute (ASI) entitled "Coordination Chemistry Environments in Iron-Containing Proteins and Enzymes - Including Smaller Molecules and Model Systems" are summarized in this book. The ASI was held in the Province of Alberta, Canada, from August 23 to September 4, 1981. The first half of the conference was held on the campus of the University of Alberta, Edmonton, and the second half at the Overlander Lodge, Hinton. Two other conferences had the greatest impact upon the planning for this ASI. One was a NATO ASI held in Tomar, Portugal in September of 1979, entitled "Metal Ions in Biology". Among the organizers for that conference were Allen Hill and Antonio Xavier; we are happy to acknowledge their beneficial influence on our subsequent conference. The other most influential conference was one organized by Ralph Wilkins and Dennis Darnell entitled "Methods for Determining Metal Ion Environments in Proteins" which was held in Las Cruces, New Mexico, U.S.A., January 10-12, 1979. The Las Cruces conference invited lectures were published as Volume 2 of "Advances in Inorganic Biochemistry", G. Eichhorn and L. Marzilli, editors. Front Matter....Pages i-xiii Front Matter....Pages 1-1 Iron: An Element Well-Fitted for its Task?....Pages 3-12 Substitution and Electron Transfer in Metal Complexes—Particularly those of Iron....Pages 13-24 Oxidation States, Redox Potentials and Spin States....Pages 25-42 Front Matter....Pages 43-43 Ferritin — The Structure and Function of an Iron Storage Protein....Pages 45-61 Chemistry and Physiology of the Transferrins....Pages 63-83 Coordination Chemistry of the Siderophores and Recent Studies of Synthetic Analogues....Pages 85-105 Specificity of Siderophore Iron Uptake by Fungi....Pages 107-116 Iron Uptake and Intracellular Iron Distribution in Cultured Rat Heart Cells: Effects of Iron Chelators....Pages 117-124 Front Matter....Pages 125-125 NMR Studies of Low-Spin Cytochromes....Pages 127-141 Front Matter....Pages 143-143 Substitution and Electron Transfer Processes in Hemerythrin....Pages 145-160 The Environment of the Binuclear Iron Coordination Complex in Methemerythrin....Pages 161-175 Front Matter....Pages 177-177 Simple Iron-Sulfur Proteins: Methodology for Establishing the Type of Center....Pages 179-192 Catalysis by Highly Active 12Fe-12S Containing Hydrogenases....Pages 193-206 Hydrogenases: Physiology, Location and Relevance for Sulfate Reducing and Methane Forming Bacteria....Pages 207-222 Generation, Transport and Transfer of Low-Potential Reducing Equivalents in Nitrogenase Catalysis....Pages 223-240 Mössbauer and EPR Evidence on the Prosthetic Groups of the MoFe Protein....Pages 241-258 Front Matter....Pages 259-259 Magnetic Complexities in Porphinatoiron(III) Complexes....Pages 261-272 The Evaluation of Stabilization Energies (Empirical Resonance Energies) for Benzene, Porphine and [18] Annulene from Thermochemical Data, and from AB Initio Calculations....Pages 273-281 Models for Peroxidase and Cytochrome P-450 Enzymes....Pages 283-294 Structure and Spectra of Stable and Transient States and Mechanisms of Oxidation of Model Cytochrome P-450....Pages 295-312 Front Matter....Pages 259-259 Hemes of Hydroporphyrins....Pages 313-334 Front Matter....Pages 335-335 Peroxidases....Pages 337-355 The State of Protonation of the Proximal Histidyl Imidazole in Horseradish Peroxidase....Pages 357-373 Coordination Characteristics of Proximal Histidine of Plant Peroxidases and their Relevance to the Heme-Linked Ionization....Pages 375-389 Compounds I of Horseradish and Yeast Cytochrome C Peroxidases....Pages 391-403 Cytochrome P450: Structure and States....Pages 405-412 Cytochrome P450 as a Reductase and Oxene Transferase: Which is its Characteristic Function ?....Pages 413-425 Catalases and Iron-Porphyrin Model Systems: Roles of the Coordination Environment of Iron in Catalytic Mechanisms....Pages 427-438 The Structure of Beef Liver Catalase....Pages 439-458 The Subunits of Cytochrome C Oxidase....Pages 459-473 Extended x-ray absorption fine structure of the copper sites in Cytochrome C Oxidase....Pages 475-484 Back Matter....Pages 485-517 Proceedings of the NATO Advanced Study Institute, Edmonton, Alberta, Canada, August 23-September 4, 1981