The Baboon in Biomedical Research (Developments in Primatology : Progress and Prospects) [ISBN : 9780387759906] [Copyright Year : 2009] [Hardcover]

Building on the foundation of two earlier volumes, __The Baboon in Biomedical Research__ returns in an updated edition that presents the variety of uses and the importance of the baboon in biomedical research today. With contributions from leading researchers who use the baboon model, the new edition, edited by John L. VandeBerg, Suzette D. Tardif, and Sarah Williams-Blangero, provides a cogent introduction to this nonhuman primate model and serves as a valuable guide for researchers as well as laboratory animal veterinarians. The volume begins with a chapter on the baboon gene map, the first genetic linkage map developed for any nonhuman primate species. Subsequent chapters present the results of decades of research on basic biological characteristics of baboons: microbiology, reproductive biology, growth and development, behavior, and spontaneous pathology. The remaining chapters summarize the scientific contributions of baboons as models of human diseases or physiological or developmental characteristics, including neonatal lung disease, dental development, dyslipidemia and atherosclerosis, pregnancy, ingestive behaviors, infant nutrition, alcoholic liver disease, drug abuse, neuroimaging, epilepsy, and xenotransplantation. The baboon already has a 50-year history of significant contributions as a model for human states of health and disease. This volume highlights the exciting research that is currently being conducted with this animal model and suggests future directions for the baboon in biomedical research.

The present volume was written to provide an overview of many diverse areas of biomedical research to which the baboon has made and continues to make important contributions. Each chapter reviews the recent literature on the topic, discusses work in progress, and presents the authors’ vision of research opportunities and likely future contributions of the baboon model to human medicine.

The baboon is a relative newcomer to the repertoire of nonhuman primates used in biomedical research. However, in less than 50 years since its first use in the U.S. it has become one of the most popular laboratory primate species. It is larger than the other widely used monkey species, making it advantageous for many types of experiments and technological developments. It is extraordinarily hardy and highly fecund in captivity. It closely resembles humans in a variety of physiological and disease processes, such as cholesterol metabolism, early stages of atherosclerosis, and alcoholic liver disease. Its chromosomes closely resemble those of humans, and many genes of the two species lie in the same chromosomal order. Among all primates, baboons are the most widely used as models for the genetics of susceptibility to complex diseases and they are the first nonhuman primate for which a framework genetic linkage map was established. In addition, the baboon genome is currently being sequenced, and as a result the utility of this species for biomedical research will be dramatically increased. For all of these reasons, the baboon is certain to continue as one of the premier nonhuman species used in medical research.

"Building on the foundation of two earlier volumes, The Baboon in Biomedical Research returns in an updated edition that presents the variety of uses and the importance of the baboon in biomedical research today. With contributions from leading researchers who use the baboon model, the new edition, edited by John L. VandeBerg, Sarah Williams-Blangero, and Suzette D.Tardif, provides a cogent introduction to this nonhuman primate model and serves as a valuable guide for researchers as well as laboratory animal veterinarians." "The volume begins with a chapter on the baboon gene map, the first genetic linkage map developed for any nonhuman primate species. Subsequent chapters present the results of decades of research on basic biological characteristics of baboons: microbiology, reproductive biology, growth and development, behavior, and spontaneous pathology.The remaining chapters summarize the scientific contributions of baboons as models of human diseases or physiological or developmental characteristics, including neonatal lung disease, dental development, dyslipidemia and atherosclerosis, pregnancy, ingestive behaviors, infant nutrition, alcoholic liver disease, drug abuse, neuroimaging, epilepsy, and xenotransplantation.The baboon already has a 50-year history of significant contributions as a model for human states of health and disease.This volume highlights the exciting research that is currently being conducted with this animal model and suggests future directions for the baboon in biomedical research." --Book Jacket Nonhuman primates have played critical roles in biomedical research, and they are among the few animals whose use in research continues to increase. The scienti?c value of nonhuman primates derives from their close phylogenetic proximity to man and their consequent anatomic, physiologic, and genetic similarities to man. Only nonhuman primates can provide adequate models for many complex physiological and disease processes of humans. The baboon is a relative newcomer to the repertoire of nonhuman primates used in biomedical research. However, in less than 50 years since its ?rst use in the U. S. , it has become one of the most popular laboratory primate species. It is larger than the other widely used monkey species, making it advantageous for many types of experiments and technological developments. It is extraordinarily hardy and highly fecund in captivity. It closely resembles humans in a variety of physiological and disease processes, such as cholesterol metabolism, early stages of atherosclerosis, and alcoholic liver disease. Its chromosomes closely resemble those of humans, and many genes of the two species lie in the same chromosomal order. Among all primates, baboons are the most widely used models for the genetics of susceptibility to complex diseases and they are the ?rst nonhuman primate for which a framework genetic linkage map was established. In addition, the baboon genome is currently being sequenced, and as a result the utility of this species for biomedical research will be dramatically increased. The development and status of the baboon genetic linkage map / Jeffrey Rogers, Michael C. Mahaney, and Laura A. Cox The study of captive baboon behavior / Linda Brent Spontaneous pathology of baboons / Gene B. Hubbard Growth and development of baboons / Steven R. Leigh Reproductive biology of baboons / Erika K. Honoré and Suzette D. Tardif Microbiology of captive baboons / Richard Eberle ... [et al.] Baboon model for endometriosis / Thomas M. D'Hooghe, Cleophas K. Kyama, and Jason M. Mwenda The baboon in embryology and teratology research / Andrew G. Hendrickx and Pamela E. Peterson Baboon models for neonatal lung disease / Bradley A. Yoder, Donald C. McCurnin, and Jacqueline J. Coalson The baboon model for dental development / Leslea J. Hlusko and Michael C. Mahaney Baboon model for dyslipidemia and atherosclerosis / David L. Rrainwater and John L. VandeBerg Baboon model for the study of nutritional influences in pregnancy / Peter W. Nathanielsz ... [et al.] Baboon model for infant nutrition / Glen E, Mott and douglas S. Lewis Baboon model for ingestive behaviors / John R. Blair-West ... [et al.] Baboon model for alcoholic liver disease : 1973-2003 / Charles S. Lieber, Maria A. Leo, and Leonore M. DeCarli Baboons in drug abuse research / Robert D. Hienz and Elise M. Weerts Neuroimaging in baboons / Kevin J. Black ... [et al.] The baboon model of epilepsy : current applications in biomedical research / C. Ákos Szabó ... [et al.] The baboon in xenotransplant research / Leonard L. Bailey. Front Matter....Pages i-xxiii The Development and Status of the Baboon Genetic Linkage Map....Pages 1-19 The Study of Captive Baboon Behavior....Pages 21-34 Spontaneous Pathology of Baboons....Pages 35-55 Growth and Development of Baboons....Pages 57-88 Reproductive Biology of Baboons....Pages 89-110 Microbiology of Captive Baboons....Pages 111-138 Baboon Model for Endometriosis....Pages 139-156 The Baboon in Embryology and Teratology Research....Pages 157-178 Baboon Models for Neonatal Lung Disease....Pages 179-205 The Baboon Model for Dental Development....Pages 207-223 Baboon Model for Dyslipidemia and Atherosclerosis....Pages 225-236 Baboon Model for the Study of Nutritional Influences on Pregnancy....Pages 237-253 Baboon Model for Infant Nutrition....Pages 255-264 Baboon Model for Ingestive Behaviors....Pages 265-283 Baboon Model for Alcoholic Liver Disease: 1973–2003....Pages 285-301 Baboons in Drug Abuse Research....Pages 303-325 Neuroimaging in Baboons....Pages 327-350 The Baboon Model of Epilepsy: Current Applications in Biomedical Research....Pages 351-370 The Baboon in Xenotransplant Research....Pages 371-380 Back Matter....Pages 381-391 The baboon has become one of the most popular laboratory primate species. This book offers an overview of many diverse areas of biomedical research to which the baboon has made important contributions