Textbook of Hepatology: From Basic Science to Clinical Practice, 2 Volume in one file, 3rd ed two volumes in one file

THE encyclopedic guide to hepatology – for consultation by clinicians and basic scientists Previously the Oxford Textbook of Clinical Hepatology , this two-volume textbook is now with Blackwell Publishing. It covers basic, clinical and translational science (converting basic science discoveries into the practical applications to benefit people). Edited by ten leading experts in the liver and biliary tract and their diseases, along with outstanding contributions from over 200 international clinicians, this text has global references, evidence and extensive subject matter – giving you the best science and clinical practice discussed by the best authors. It includes unique sections on: Symptoms and signs in liver disease Industrial diseases affecting the liver The effects of diseases of other systems on the liver The effects of liver diseases on other systems It’s bigger and more extensive than other books and discusses new areas in more depth such as stem cells, genetics, genomics, proteomics, transplantation, mathematics and much more. Plus, it comes with a fully searchable CD ROM of the entire content. Click here to view a sample chapter on the liver and coagulation Cover......Page 1 Textbook of Hepatology: From Basic Science to Clinical Practice......Page 2 Copyright......Page 5 Contributors......Page 12 Foreword......Page 22 Preface to the third edition......Page 23 Preface to the first edition......Page 24 1 Architecture of the liver......Page 25 1.1 Macroscopic anatomy of the liver......Page 26 1.2 Liver and biliary tract histology......Page 32 1.3 Ultrastructure of the hepatocyte......Page 43 1.4 Liver sinusoidal endothelial cells......Page 52 1.5 Kupffer cells......Page 59 1.6 The hepatic stellate cell......Page 66 1.7 Biliary epithelial cells......Page 75 1.8 Hepatic stem cells......Page 81 1.9 Embryology of the liver and intrahepatic biliary tract......Page 88 2 Functions of the liver......Page 95 2.1 Hepatic circulation......Page 96 2.2 Functions of the liver......Page 110 2.3 Metabolism......Page 150 2.4 Synthetic function......Page 271 2.5 Regulation of the liver cell mass......Page 295 2.6 Excretion......Page 311 2.7 Immunology of the liver......Page 333 3 Basic concepts in pathobiology......Page 353 3.1 Hepatocyte apoptosis and necrosis......Page 354 3.2 Ischaemia–reperfusion injury to the liver......Page 367 3.3 Genetics and liver diseases......Page 375 3.4 Cellular cholestasis......Page 403 3.5 Oncogenes and tumour suppressor genes......Page 410 3.6 Genomics, gene arrays and proteomics in the study of liver disease......Page 417 4 Pathology......Page 440 4.1 Histological features......Page 441 4.2 Classifications, scoring systems and morphometry in liver pathology......Page 451 5 Investigation of hepatobiliary disease......Page 459 5.1 Signs and symptoms of liver disease......Page 460 5.2 Biochemical investigations in the management of liver disease......Page 468 5.3 Hepatic removal kinetics: importance for quantitative measurements of liver function......Page 485 5.4 Immunological investigations in liver diseases......Page 496 5.5 Biopsy and laparoscopy......Page 506 5.6 Imaging of the liver......Page 517 5.7 Interventional radiology in hepatobiliary diseases......Page 566 5.8 Positron emission tomography of the liver......Page 578 5.9 Splanchnic haemodynamic investigations......Page 584 5.10 The Cochrane Hepatobiliary Group......Page 589 6 Cirrhosis......Page 597 6.1 The evolution of cirrhosis......Page 598 6.2 Cellular and molecular pathobiology of liver fibrosis and its pharmacological intervention......Page 605 6.3 Clinical and diagnostic aspects of cirrhosis......Page 619 7 Portal hypertension and its complications......Page 635 7.1 Anatomy of the portal venous system in portal hypertension......Page 636 7.2 Pathogenesis of portal hypertension......Page 643 7.3 Clinical manifestations and management of bleeding episodes in cirrhotics......Page 653 7.4 Haemodynamic assessment of portal hypertension......Page 671 7.5 Pathogenesis, diagnosis and treatment of ascites in cirrhosis......Page 679 7.6 Hepatorenal syndrome......Page 724 7.7 Pulmonary complications of portal hypertension......Page 733 7.8 Hepatic encephalopathy......Page 741 7.9 Bacterial infections in portal hypertension......Page 774 7.10 Hypersplenism......Page 784 8 Congenital hepatic fibrosis and non-parasitic cystic lesions of the liver and bile ducts......Page 792 8.1 Congenital conditions......Page 793 8.2 Acquired conditions......Page 822 9 Viral infections of the liver......Page 830 9.1 Viral hepatitis......Page 831 9.2 Systemic virosis producing hepatitis......Page 967 9.3 Human immunodeficiency virus and the liver......Page 984 9.4 Exotic virus infections of the liver......Page 998 10 Other infections of the liver......Page 1009 10.1 Bacterial, rickettsial and spirochaetal infections......Page 1010 10.2 Fungal infections affecting the liver......Page 1020 10.3 Protozoal infections affecting the liver......Page 1029 10.4 Helminthiasis......Page 1049 11 Immune disorders of the liver......Page 1077 11.1 Primary biliary cirrhosis......Page 1078 11.2 Autoimmune hepatitis......Page 1096 11.3 Sclerosing cholangitis......Page 1110 11.4 Vanishing bile duct syndrome......Page 1118 11.5 Overlap syndromes......Page 1127 12 Alcoholic liver disease......Page 1134 12.1 Epidemiological aspects of alcoholic liver disease......Page 1135 12.2 Ethanol metabolism and pathogenesis of alcoholic liver injury......Page 1141 12.3 Pathology of alcoholic liver disease......Page 1154 12.4 Alcoholic liver disease: natural history, diagnosis, clinical features, evaluation, prognosis and management......Page 1163 12.5 Management of the alcoholic patient, including alcoholism and extrahepatic manifestations......Page 1185 13 Hepatic non-alcoholic steatosis......Page 1198 13 Non-alcoholic fatty liver and non-alcoholic steatohepatitis......Page 1199 14 Toxic liver injury......Page 1213 14.1 Drug-induced liver injury......Page 1214 14.2 Toxic liver injury......Page 1272 14.3 Hepatic injury due to physical agents......Page 1280 14.4 Hepatic toxicity induced by herbal medicines......Page 1284 15 Acute liver failure......Page 1292 15 Acute liver failure and related syndromes......Page 1293 16 Genetic and metabolic diseases......Page 1315 16.1 Wilson’s disease......Page 1316 16.2 Haemochromatosis......Page 1324 16.3 Alpha-1-antitrypsin deficiency and related disorders......Page 1331 16.4 The liver in cystic fibrosis......Page 1337 16.5 Human hereditary porphyrias......Page 1344 16.6 Hyperbilirubinaemia......Page 1353 16.7 The liver in intracellular and extracellular lipidosis......Page 1361 16.8 Glycogen storage diseases......Page 1371 16.9 Mitochondriopathies......Page 1378 16.10 Genetic cholestatic diseases......Page 1384 17 Vascular diseases......Page 1390 17.1 Hepatic artery diseases......Page 1391 17.2 Obstruction of the portal vein......Page 1395 17.3 Disorders of the hepatic veins and hepatic sinusoids......Page 1403 17.4 Congenital vascular malformations......Page 1418 18 Tumours of the liver......Page 1424 18.1 Benign hepatic tumours......Page 1425 18.2 Malignant tumours......Page 1435 18.3 Metastatic tumours......Page 1462 19 Biliary tract diseases......Page 1477 19.1 Intrahepatic cholestasis......Page 1478 19.2 Extrahepatic biliary obstruction: systemic effects, diagnosis and management......Page 1498 19.3 Gallstone disease......Page 1515 19.4 Cholangitis and biliary tract infections......Page 1538 19.5 Haemobilia......Page 1547 19.6 Biliary dyskinesia......Page 1558 19.7 Benign biliary tumours......Page 1570 19.8 Gallbladder carcinoma......Page 1572 19.9 Cholangiocarcinoma......Page 1580 20 The liver in diseases of other systems......Page 1603 20.1 The liver in cardiovascular disease......Page 1604 20.2 The liver in lung diseases......Page 1611 20.3 The effect of gastrointestinal diseases on the liver and biliary tract......Page 1617 20.4 Total parenteral nutrition-related liver disease......Page 1629 20.5 The effect of skin diseases on the liver......Page 1637 20.6 The liver in urogenital diseases......Page 1648 20.7 The effect of haematological and lymphatic diseases on the liver......Page 1657 20.8 The liver in graft-vs.-host disease......Page 1666 20.9 The effect of endocrine diseases on liver function......Page 1675 20.10 Musculoskeletal diseases and the liver......Page 1689 20.11 Amyloidosis......Page 1697 20.12 Hepatic granulomas......Page 1704 21 The impact of liver disease on other systems......Page 1713 21.1 The effect of liver disease on the cardiovascular system......Page 1714 21.2 The effect of liver disease on the endocrine system......Page 1725 21.3 Haematological abnormalities in liver disease......Page 1760 21.4 Haemostasis in liver disease......Page 1773 21.5 The effect of liver disease on the gastrointestinal tract......Page 1791 21.6 The effect of liver disease on the skin......Page 1797 21.7 The effect of liver disease on the urogenital tract......Page 1808 21.8 The nervous system in liver disease......Page 1815 21.9 The effect of liver disease on bone......Page 1822 21.10 The effect of liver disease on nutritional status and energy metabolism......Page 1829 22 The liver in specific settings......Page 1836 22.1 Paediatric liver diseases......Page 1837 22.2 Liver diseases in the elderly......Page 1862 22.3 Liver diseases and pregnancy......Page 1871 23 The management of liver diseases......Page 1888 23.1 The general management of liver diseases......Page 1889 23.2 Nutritional aspects of liver and biliary disease......Page 1895 23.3 Prescribing drugs in liver disease......Page 1902 23.4 Management of pretransplant patients......Page 1912 24 Surgery, anaesthesia and the liver......Page 1921 24.1 General surgical aspects and the risks of liver surgery in patients with hepatic disease......Page 1922 24.2 Anaesthesia and liver disease......Page 1927 24.3 Postoperative jaundice......Page 1934 24.4 Hepatobiliary trauma......Page 1942 25 Liver transplantation......Page 1951 25.1 Surgical techniques......Page 1952 25.2 Liver transplantation: indications, contraindications and results......Page 1971 25.3 The perioperative care and complications of liver transplantation......Page 1983 25.4 Immunosuppression......Page 1990 25.5 Recurrent disease and management in liver transplantation......Page 1997 25.6 Post-transplantation management and complications......Page 2006 25.7 Liver transplantation and quality of life......Page 2014 25.8 Emerging therapies......Page 2019 26 Mathematics in hepatology......Page 2040 26.1 Models in clinical hepatology......Page 2041 26.2 Outcomes research in hepatology......Page 2051 26.3 Meta-analysis......Page 2059 26.4 Economic considerations in hepatology......Page 2066 26.5 Development of the liver interactome: mapping the regulatory networks......Page 2074 27 Appendices......Page 2082 27.1 Geographic distribution of infections causing liver disease......Page 2083 27.2 Liver injury in man ascribed to non-drug chemicals and natural toxins......Page 2089 27.3 Rare diseases with hepatic abnormalities......Page 2106 Index......Page 2145 booktext@ID=117928352&PLACEBO=IE.pdf......Page 2221 THE encyclopedic guide to hepatology for consultation by clinicians and basic scientists Previously the Oxford Textbook of Clinical Hepatology , this two-volume textbook is now with Blackwell Publishing. It covers basic, clinical and translational science (converting basic science discoveries into the practical applications to benefit people). Edited by ten leading experts in the liver and biliary tract and their diseases, along with outstanding contributions from over 200 international clinicians, this text has global references, evidence and extensive subject matter giving you the best science and clinical practice discussed by the best authors. It includes unique sections on: Its bigger and more extensive than other books and discusses new areas in more depth such as stem cells, genetics, genomics, proteomics, transplantation, mathematics and much more. Plus, it comes with a fully searchable CD ROM of the entire content. Click here to view a sample chapter on the liver and coagulation