Textbook of Biochemistry for Medical Students / Revision Exercises Based on Textbook of Biochemistry

With this Ninth edition, the Textbook of Biochemistry for Medical Students is entering in the 24th year of existence. The Medical Council of India has accepted it as one of the standard textbooks. This book has also reached the hands of medical students of neighbouring countries of Nepal, Pakistan, Bangladesh, Sri Lanka, etc; and distant countries in Africa and Europe. The textbook has a Spanish edition, with wide circulation in Central and South America. Slovak edition has also been published. Apart from the medical community, this book has also become popular among other biology group of students in India. The Medical Council of India has recently revised the MBBS curriculum, and this new edition incorporates all the relevant points and strictly adheres to the new curriculum. Cover......Page 1 Preface......Page 6 Contents......Page 9 1. Biochemical Perspective to Medicine......Page 16 2. Subcellular Organelles and Cell Membranes......Page 22 3. Amino Acids Structure and Properties......Page 34 4. Proteins Structure and Function......Page 42 5. Enzymology General Concepts and Enzyme Kinetics......Page 55 6. Chemistry of Carbohydrates......Page 75 7. Chemistry of Lipids......Page 88 8. Overview of Metabolism......Page 98 9. Major Metabolic Pathways of Glucose......Page 105 10. Minor Metabolic Pathways of Carbohydrates......Page 128 11. Metabolism of Fatty Acids......Page 142 12. Cholesterol and Lipoproteins......Page 161 13. MCFA, PUFA, Prostaglandins and Compound Lipids......Page 175 14. General Amino Acid Metabolism (Urea Cycle, One Carbon Metabolism)......Page 185 15. Simple, Hydroxy and Sulfur Containing Amino Acids......Page 198 16. Acidic, Basic and Branched Chain Amino Acids......Page 209 17. Aromatic Amino Acids and Amino Acidurias......Page 218 18. Citric Acid Cycle......Page 231 19. Biological Oxidation and Electron Transport Chain......Page 238 20. Free Radicals and Anti-oxidants......Page 251 21. Heme Synthesis and Breakdown......Page 257 22. Hemoglobin......Page 269 23. Clinical Enzymology and Biomarkers......Page 281 24. Regulation of Blood Glucose, Insulin and Diabetes......Page 289 25. Cardiovascular Diseases and Hyperlipidemias......Page 307 26. Liver and Gastric Function Tests......Page 316 27. Kidney Function Tests......Page 329 28. Plasma Proteins......Page 344 29. Acid-Base Balance and pH......Page 354 30. Electrolyte and Water Balance......Page 370 31. Body Fluids (Milk, CSF, Amniotic Fluid)......Page 380 32. Clinical Laboratory Screening of Metabolic Disease......Page 383 33. Fat Soluble Vitamins (A, D, E, K)......Page 394 34. Water Soluble Vitamins......Page 406 35. Mineral Metabolism and Abnormalities......Page 426 36. Energy Metabolism and Nutrition......Page 447 37. Detoxification and Biotransformation of Xenobiotics......Page 461 38. Environmental Pollution and Heavy Metal Poisons......Page 466 39. Nucleotides Chemistry and Metabolism......Page 472 40. Deoxyribo Nucleic Acid (DNA) Structure and Replication......Page 484 41. Transcription and Translation......Page 496 42. Inheritance, Mutations and Control of Gene Expression......Page 513 43. Recombinant DNA Technology and Gene Therapy......Page 527 44. Mechanisms of Action of Hormones......Page 535 45. Hypothalamic and Pituitary Hormones......Page 543 46. Steroid Hormones......Page 547 47. Thyroid Hormones......Page 553 48. Signal Molecules and Growth Factors......Page 558 49. Immunochemistry......Page 568 50. Biochemistry of AIDS and HIV......Page 578 51. Biochemistry of Cancer......Page 582 52. Tissue Proteins in Health and Disease......Page 596 53. Applications of Isotopes in Medicine......Page 607 54. General Techniques for Separation, Purification a......Page 614 55. Molecular Diagnostics......Page 627 Appendices......Page 640 Index......Page 652 This book contains an amalgamation of the essentials of basic biochemistry along with the advanced knowledge in the frontiers of molecular biology. The first edition of the book was published in 1995, and is now running the 6th edition. The book is now accepted as a standard textbook in all the medical colleges in India and abroad. Total of more than 100,000 copies have already been sold. The book has been designed with 7 sections. Section A deals with chemical basis of life. Section B is devoted to general metabolism. Section C describes clinical and applied biochemistry. Section D develops the clinical nutrition. Section E elaborates molecular biology. Section F denotes hormones and homeostasis. Section G is for advanced biochemistry. The 6th edition contains about 1,100 figures, 230 tables and 200 boxes, altogether making the book very student-friendly. Much emphasis has been given on clinical aspect of biochemistry, and the book is written aiming the students who are going to become practicing physicians. For example, chapter 24 gives the metabolic alterations in Diabetes Mellitus and in pre-diabetic states. Chapter 25 shows the relationship of cholesterol and lipoproteins with myocardial infarction. Chapter 26 gives the routine and special investigations done to identify liver diseases. Chapter 27 contains the alterations of parameters during kidney disease. Chapter 29 identifies the alterations in acid base balance and the life threatening conditions leading to changes in blood pH. Chapters on clinical chemistry have been extensively updated and clinically relevant points were further added. Out of the total 600 pages, more than 200 pages are devoted to the Clinical Biochemistry and Nutrition. Another 75 pages are devoted to the advances in Molecular Biology. Page 265 gives the details of cardiac markers, the alterations in serum enzymes during myocardial infarction. This text will keep the reader updated with important advances in the field of clinical biochemistry in a comprehensive but readable format The seventh edition of this book is a comprehensive guide to biochemistry for medical students. Divided into six sections, the book examines in depth topics relating to chemical basics of life, metabolism, clinical and applied biochemistry, nutrition, molecular biology and hormones. Includes a free booklet of revision exercises and free online access.