Textbook drug design and discovery Textbook of drug design and discovery

"Building on the success of the previous editions, the Textbook of drug design and discovery, fifth edition, has been thoroughly revised and updated to provide a complete source of information on all facets of drug design and discovery for students of chemistry, pharmacy, pharmacology, biochemistry, and medicine. The information is presented in an up-to-date review form with an underlying and fundamental focus on the educational aspects. Beginning with an introduction to drug design and discovery, the first eight chapters cover molecular recognition, ligand-based drug design, and biostructure-based drug design. The authors also discuss drug-like properties and decision making in medicinal chemistry, chemical biology, natural products in drug discovery, and in vivo imaging in drug discovery. The middle six chapters provide an overview of peptide and protein drug design, prodrugs in drug design and development, and enzyme inhibitors. The authors also go through receptors (structure, function, and pharmacology), ion channels (structure and function), and neurotransmitter transporters (structure, function, and drug binding). The following chapters address important neurotransmitter systems, GABA and glutamic acid receptors and transporter ligands, acetylcholine, histamine, dopamine and serotonin, and opioid and cannabinoid receptors. The book concludes with an examination of neglected diseases, anticancer agents, tyrosine kinase receptors, and antibiotics"--Publisher's website Chapter 1. Introduction to drug design and discovery / Ulf Madsen and Povl Krogsgaard-Larsen -- chapter 2. Molecular recognition / Thomas Balle and Tommy Liljefors -- chapter 3. Ligand-based drug design / Erica S. Burnell, David E. Jane, and Robert J. Thatcher -- chapter 4. Biostructure-based drug design / Flemming Steen JéÄłrgensen and Jette Sandholm Kastrup -- chapter 5. Drug-like properties and decision making in medicinal chemistry / Jan Kehler, Lars Kyhn Rasmussen, and Morten JéÄłrgensen -- chapter 6. Chemical biology / Louise Albertsen and Kristian StréÄłmgaard -- chapter 7. Natural products in drug discovery / Guy T. Carter -- chapter 8. In vivo imaging in drug discovery / Jesper L. Kristensen and Matthias M. Herth -- chapter 9. Peptide and protein drug design / Jesper Lau and SéÄłren Ostergaard -- chapter 10. Prodrugs in drug design and development / Jarkko Rautio and Krista Laine -- chapter 11. Enzyme inhibitors : biostructure- and mechanism-based design / Robert A. Copeland and P. Ann Boriack-Sjodin -- chapter 12. Receptors : structure, function, and pharmacology / Hans Bruner-Osborne -- chapter 13. Ion channels : structure and function / SéÄłren-Peter Olesen, Bo Hjorth Bentzen, and Daniel B. Timmermann -- chapter 14. Neurotransmitter transporters : structure, function, and drug binding / LéÄłland and Ulrik Gether -- chapter 15. GABA and glutamic acid receptor and transporter ligands / Bente FréÄłlund and Lennart Bunch -- chapter 16. Acetylcholine / Anders A. Jensen -- chapter 17. Histamine receptors / Iwan de Esch, Henk Timmerman, and Rob Leurs -- chapter 18. Dopamine and serotonin / Benny Bang-Andersen, Lena Tagmose, and Klaus P. BéÄłgeséÄł -- chapter 19. Opioid and cannabinoid receptors / Rasmus P. Clausen and Harald S. Hansen -- chapter 20. Neglected diseases / SéÄłren B. Christensen and Ib C. Bygbjerg -- chapter 21. Anticancer agents / Fredrik BjéÄłrkling, Jose Moreira, and Jan Stenvang -- chapter 22. Targeting receptor tyrosine / Bo Falck Hansen and Steen Gammeltoft -- chapter 23. Antibiotics / Smitha Rao C.V., Piet Herdewijn, and Anastassios Economou Content: Cover Half Title Title Page Copyright Page Contents Preface Editors Contributors Chapter 1 Introduction to Drug Design and Discovery Chapter 2 Molecular Recognition Chapter 3 Ligand-Based Drug Design Chapter 4 Biostructure-Based Drug Design Chapter 5 Drug-Like Properties and Decision Making in Medicinal Chemistry Chapter 6 Chemical Biology Chapter 7 Natural Products in Drug Discovery Chapter 8 In€Vivo Imaging in Drug Discovery Chapter 9 Peptide and Protein Drug Design Chapter 10 Prodrugs in Drug Design and Development. Chapter 11 Enzyme Inhibitors: Biostructure-and Mechanism-Based DesignChapter 12 Receptors: Structure, Function, €and Pharmacology Chapter 13 Ion Channels: Structure and Function Chapter 14 Neurotransmitter Transporters: Structure, Function, and Drug Binding Chapter 15 GABA and Glutamic Acid Receptor and Transporter Ligands Chapter 16 Acetylcholine Chapter 17 Histamine Receptors Chapter 18 Dopamine and Serotonin Chapter 19 Opioid and Cannabinoid Receptors Chapter 20 Neglected Diseases Chapter 21 Anticancer Agents Chapter 22 Targeting Receptor Tyrosine Kinases Chapter 23 Antibiotics.