Targeting of Drugs 2: Optimization Strategies (Nato Science Series A:, 199)

Proceedings of a NATO ASI held in Cape Sounion, Greece, June 24-July 5, 1989 Front Matter....Pages i-viii Biological Dispersion and the Design of Site-Specific Protein Therapeutic Systems....Pages 1-19 Recombinant Ligand-Toxin Conjugates, Domain Engineering and the Search for Targeted Pharmaceuticals....Pages 21-27 Extravascular Diffusion and Convection of Antibodies in Tumors....Pages 29-38 Antitumor Effects of Six Ricin A-Chain Immunotoxins of Potential Use in the Treatment of Hodgkin’S Disease....Pages 39-47 Enhancement of Hormone Activity by Monoclonal Antibodies....Pages 49-56 Modeling of Cell Membrane Targeting: Specific Recognition, Binding, and Protein Domain Formation in Ligand-Containing Model Biomembranes....Pages 57-76 Endocytosis of Cell Surface Molecules and Intracellular Delivery of Materials Encapsulated in Targeted Liposomes....Pages 77-86 Tissue Specific Serum Opsonins and Phagocytosis of Liposomes....Pages 87-94 Liposome Targeting to Tumor Cells in Vivo....Pages 95-101 Stabilization of Lipid Microstructures: Fundamentals and Applications....Pages 103-115 Non-Ionic Surfactant Vesicles as Carriers of Doxorubicin....Pages 117-126 Targeted Therapy of Liver Carcinoma....Pages 127-135 Drug Delivery Systems: The Industrial View....Pages 137-153 Controlled Delivery to the Brain....Pages 155-163 Polymeric Delivery Systems....Pages 165-175 Back Matter....Pages 177-185 The proceedings from the latest in the biannual series of meetings dealing with the targeting of drugs contain 15 papers focusing on the strategies by which milieu interference curtailing the function of drug carriers is circumvented or removed. The topics include extravascular diffusion and convect