Targeted Therapies: Mechanisms of Resistance (Molecular and Translational Medicine)

This volume explores the mechanisms of resistance to targeted therapeutics. The focus is on the cancer cell signaling network, although other mechanisms of resistance including target mutation, and new areas of study such as cancer stem cells are included. Targeted Therapies: Mechanisms of Resistance highlights examples of changes in the signaling network in response to inhibition of a signaling event and underscores the importance in having a mechanistic understanding of the signaling network in cancer for developing effective targeted cancer therapies. Moreover, cutting edge tools to analyze the cell signaling network will be discussed. This includes the leading edge of techniques as well as computational biology and systems theory. This volume provides the reader with both an overview as well as a detailed perspective on the mechanisms of resistance to targeted therapeutics and will be of great value to the oncologist, the physician-scientist treating patients and the translational scientist working on any aspect of targeted therapeutics. Resistance to targeted therapies as a result of mutation(s) in the target / Alexis B. Cortot and Pasi A. Jänne The dynamics of the cell signaling network; implications for targeted therapies / Daniel Gioeli Cancer signaling network analysis by quantitative mass spectrometry / Jason R. Neil and Forest M. White Development and implementation of array technologies for proteomics : clinical implications and applications / Julie D. Wulfkuhle ... [et. al] Using phosphoflow[tm] to study signaling events of subpopulations resistant to current therapies / Omar D. Perez Mathematical and computational models in cancer / Sudhir Chowbina ... [et al.] Somatic evolution of acquired drug resistance in cancer / John W. Pepper Interrogating resistance to targeted therapy using genetically engineered mouse models of cancer / Edward Gunther microRNA : a potential therapy able to target multiple cancer pathways / Benjamin Kefas and Benjamin W. Purow Rational combination of targeted agents to overcome cancer cell resistance / Yun Dai and Steven Grant. Front Matter....Pages i-xiv Resistance to Targeted Therapies As a Result of Mutation(s) in the Target....Pages 1-31 The Dynamics of the Cell Signaling Network; Implications for Targeted Therapies....Pages 33-53 Cancer Signaling Network Analysis by Quantitative Mass Spectrometry....Pages 55-75 Development and Implementation of Array Technologies for Proteomics: Clinical Implications and Applications....Pages 77-94 Using PhosphoflowTM to Study Signaling Events of Subpopulations Resistant to Current Therapies....Pages 95-112 Mathematical and Computational Models in Cancer....Pages 113-126 Somatic Evolution of Acquired Drug Resistance in Cancer....Pages 127-134 Interrogating Resistance to Targeted Therapy Using Genetically Engineered Mouse Models of Cancer....Pages 135-153 microRNA: A Potential Therapy Able to Target Multiple Cancer Pathways....Pages 155-170 Rational Combination of Targeted Agents to Overcome Cancer Cell Resistance....Pages 171-195 Back Matter....Pages 197-201 Targeted Therapies highlights changes in the signaling network in response to inhibition of a signaling event. The text illustrates how a mechanistic understanding of the signaling network in cancer is important to developing targeted cancer therapies.