T-Cell and NK-Cell Lymphomas : From Biology to Novel Therapies

In this book, a group of internationally distinguished lymphoma experts provide a comprehensive review of the most important advances in the biology, diagnosis, and therapy of T cell and NK cell malignancies. In particular, it demonstrates in detail how advances in our understanding of the tumor microenvironment and molecular biology have helped to elucidate the pathogenesis of these lymphomas, improve diagnostic and prognostic accuracy, and develop novel therapies that promise improved patient outcomes. Individual chapters are devoted to particular tumor types and subtypes, and all aspects of transplantation for patients with T cell and NK cell lymphomas are discussed. As such, the book offers a valuable resource for hematologists, oncologists, hematopathologists, and all those seeking an up-to-date overview of how new, targeted therapies are delivering better disease control and improved quality of life. Front Matter ....Pages i-viii Epidemiology and Pathology of T- and NK-Cell Lymphomas (Parwiz J. Siaghani, Jerry T. Wong, John Chan, Dennis D. Weisenburger, Joo Y. Song)....Pages 1-29 Molecular and Genomic Landscape of Peripheral T-Cell Lymphoma (Javeed Iqbal, Catalina Amador, Timothy W. McKeithan, Wing C. Chan)....Pages 31-68 Tumor Microenvironment in T-Cell Lymphomas (N. Nora Bennani, Stephen M. Ansell)....Pages 69-82 Peripheral T-Cell Lymphoma, not Otherwise Specified (PTCL-NOS) (Adetokunbo Oluwasanjo, Saritha Kartan, William Johnson, Onder Alpdogan, Alejandro Gru, Anjali Mishra et al.)....Pages 83-98 Angioimmunoblastic T-Cell Lymphoma (Mariko Yabe, Ahmet Dogan, Steven M. Horwitz, Alison J. Moskowitz)....Pages 99-126 Anaplastic Large Cell Lymphoma: Contemporary Concepts and Optimal Management (Andrei Shustov, Lorinda Soma)....Pages 127-144 Adult T-Cell Leukemia-Lymphoma (Wataru Munakata, Kensei Tobinai)....Pages 145-161 NK-Cell Lymphomas (Dai Chihara, Yasuhiro Oki)....Pages 163-184 Hepatosplenic T-Cell Lymphomas (Lohith Gowda, Francine Foss)....Pages 185-193 Rare T-Cell Subtypes (C. van der Weyden, C. McCormack, S. Lade, R. W. Johnstone, H. M. Prince)....Pages 195-224 Primary Cutaneous T-Cell Lymphomas: Mycosis Fungoides and Sezary Syndrome (Christiane Querfeld, Jasmine Zain, Steven T. Rosen)....Pages 225-248 CD30-Positive Lymphoproliferative Disorders (Liana Nikolaenko, Jasmine Zain, Steven T. Rosen, Christiane Querfeld)....Pages 249-268 Transplantation (Jasmine Zain)....Pages 269-287