Systems Biology of Tumor Physiology: Rethinking the Past, Defining the Future (SpringerBriefs in Cancer Research)

This exciting SpringerBrief presents evidence for new ideas that will challenge several theories of how cancer biology is understood. Cancer biology has undergone several intellectual revolutions in the past 50 years. A mutation-centric view of cancer has given way to the tumor microenvironment view. Reductionistic studies of one gene at a time have given way to systems biology approaches that analyze the whole genome (omics) at the same time. However, this text combines the complex levels studying cancer at the molecular biology level, endocrinology level, and transcriptomics level. What researchers are now realizing is that there is a need to combine omics with physiology concepts in order to better understand cancer and this book will give insight to the merging of these two fields in order to define how cancer is studied in the future.​ Front Matter....Pages i-xiii Macrophages, Extracellular Matrix, and Estrogens in Breast Cancer Risk....Pages 1-19 Cellular Plasticity, Cancer Stem Cells, and Cells-of-Origin....Pages 21-31 Using Mouse Models and Making Sense of Them....Pages 33-54 Back Matter....Pages 55-56