Systems Biology of Tumor Dormancy (Advances in Experimental Medicine and Biology Book 734)

This volume is based on the Workshop on Systems Biology of Tumor Dormancy meeting, held July 25th to July 28th, 2011. The first annual CCSB workshop brought together biologists, clinicians, mathematicians, and computer scientists to discuss various aspects of tumor dormancy and develop novel mathematical/computational models with the keynote speakers. Specific topics included the angiogenic switch, immune system interactions, cancer stem cells and signaling. Front Matter....Pages i-xviii Front Matter....Pages 1-1 Genes and Regulatory Pathways Involved in Persistence of Dormant Micro-tumors....Pages 3-17 The Host Support Niche as a Control Point for Tumor Dormancy: Implications for Tumor Development and Beyond....Pages 19-35 Insights into the Regulation of Tumor Dormancy by Angiogenesis in Experimental Tumors....Pages 37-52 Front Matter....Pages 53-53 Cancer Stem Cells and Tumor Dormancy....Pages 55-71 Regulation of Tumor Cell Dormancy by Tissue Microenvironments and Autophagy....Pages 73-89 Tumor Dormancy, Oncogene Addiction, Cellular Senescence, and Self-Renewal Programs....Pages 91-107 Front Matter....Pages 109-109 Multifaceted Kinetics of Immuno-Evasion from Tumor Dormancy....Pages 111-143 Tumor Dormancy and Cancer Stem Cells: Two Sides of the Same Coin?....Pages 145-179 Tumor Dormancy: Long-Term Survival in a Hostile Environment....Pages 181-200 A Review of Mathematical Models of Cancer–Immune Interactions in the Context of Tumor Dormancy....Pages 201-234 Front Matter....Pages 235-235 Regulation of Tumor Dormancy and Role of Microenvironment: A Mathematical Model....Pages 237-259 Seeing the Invisible: How Mathematical Models Uncover Tumor Dormancy, Reconstruct the Natural History of Cancer, and Assess the Effects of Treatment....Pages 261-282 Back Matter....Pages 283-291