Sunlight, Vitamin D and Skin Cancer (Advances in Experimental Medicine and Biology (624))

UV exposuie represents the most important risk factor for the development of nonmelanoma skin cancer. Additionally, assessment of sun exposure parameters has consistently shown an association between the development of malignant melanoma and short term, intense UV exposure, particularly burning in childhood. As a consequence, protection of the skin from UV exposure is an integral part of skin cancer prevention programs. However, more chronic, less intense UV exposure has not been found to be a risk factor for melanoma and in fact has been found in some studies to be protective. Moreover, 90% of all requisite vitamin D is formed within the skin through the action of the sun—a serious problem—for a connection between vitamin D deficiency and various types of cancer (e. g. , colon, prostate and breast cancers) has been demonstrated in a large number of studies. Hence, the - sociation between vitamin D deficiency and various internal malignancies has now opened a debate among dermatologists and other clinicians how to balance between positive and negative effects of solar and artificial UV exposure. The goal of this volume is to provide a comprehensive, highly readable overview of our present knowledge of positive and negative effects of UV exposure, with a focus on vitamin D and skin cancer. The Goal Of This Volume Is To Comprehensively Cover A Highly Readable Overview On Our Present Knowledge Of Positive And Negative Effects Of Uv-exposure, With A Focus On Vitamin D And Skin Cancer. Topics That Are Discussed In-depth By Leading Researchers And Clinicians Range From The Newest Findings In Endocrinology, Epidemiology, Histology, Photobiology, Immunology, Cytogenetics And Molecular Pathology To New Concepts For Prophylaxis And Treatment. Experts In The Field As Well As Health Care Professionals Not Intimately Involved In These Specialized Areas Are Provided With The Most Significant And Timely Information Related To These Topics. It Is The Aim Of This Book To Summarize Essential Up-to-date Information For Every Clinician Or Scientist Interested In How To Balance Between Positive And Negative Effects Of Uv-exposure To Minimize The Risks Of Developing Vitamin D Deficiency And Skin Cancer. Uv-exposure Represents The Most Important Risk Factor For The Development Of No. Sunlight, Uv-radiation, Vitamin D And Skin Cancer: How Much Sunlight Do We Need? / Michael F. Holick -- Solar Ultraviolet Irradiance And Cancer Incidence And Mortality / William B. Grant -- Vitamin D Status And Cancer Incidence And Mortality / Edward Giovannucci -- Sun Exposure And Cancer Survival In Norway: Changes In The Risk Of Death With Season Of Diagnosis And Latitude / Alina Carmen Porojnicu, Arne Dahlback And Johan Moan -- Optimal Serum 25-hydroxy Vitamin D Levels For Multiple Health Outcomes / Heike A. Bischoff-ferrari -- Ultraviolet Exposure Scenarios: Risks Of Erythema From Recommendations On Cutaneous Vitamin D Synthesis / Ann R. Webb And Ola Engelsen -- At What Time Should One Go Out In The Sun? / Johan Moan, Arne Dahlback And Alina Carmen Porojnicu -- Epidemiology Of Melanoma And Nonmelanoma Skin Cancer--the Role Of Sunlight / Ulrike Leiter And Claus Garbe -- Ultraviolet Radiation And Malignant Melanoma / Johan Moan, Alina Carmen Porojnicu, And Arne Dahlback --^ Solar Uv Exposure And Mortality From Skin Tumors / Marianne Berwick ... [et Al.] -- Health Initiatives For The Prevention Of Skin Cancer / Rüdiger Greinert ... [et Al.] -- Sunscreens / Guido Bens -- Uv Damage And Dna Repair In Malignant Melanoma And Nonmelanoma Skin Cancer / Knuth Rass And Jörg Reichrath -- Role Of Viruses In The Development Of Squamous Cell Cancer And Melanoma / Ulrich R. Hengge -- Melanoma And Nonmelanoma Skin Cancers And The Immune System / Diana Santo Domingo And Elma D. Baron -- Solar Uv-radiation, Vitamin D And Skin Cancer Surveillance In Organ Transplant Recipients (otrs) / Jörg Reichrath And Bernd Nürnberg -- Histology Of Melanoma And Nonmelanoma Skin Cancer / Cornelia S.l. Mueller And Jörg Reichrath -- Cytogenetics Of Melanoma And Nonmelanoma Skin Cancer / Melanie A. Carless And Lyn R. Griffiths -- Molecular Biology Of Basal And Squamous Cell Carcinomas / Jingwu Xie -- Molecular Biology Of Malignant Melanoma -- Mar Pons ... [et Al.] --^ P53 Protein And Pathogenesis Of Melanoma And Nonmelanoma Skin Cancer / Cara L. Benjamin, Vladislava O. Melnikova And Honnavara N. Ananthaswamy -- Apoptosis And Pathogenesis Of Melanoma And Nonmelanoma Skin Cancer / Peter Erb ... [et Al.] -- Treatment Of Melanoma And Nonmelanoma Skin Cancer / Knuth Rass And Wolfgang Tilgen. Edited By Jörg Reichrath. Includes Bibliographical References And Index. Front Matter....Pages i-xxi Sunlight, UV-Radiation, Vitamin D and Skin Cancer: How Much Sunlight Do We Need?....Pages 1-15 Solar Ultraviolet Irradiance and Cancer Incidence and Mortality....Pages 16-30 Vitamin D Status and Cancer Incidence and Mortality....Pages 31-42 Sun Exposure and Cancer Survival in Norway: Changes in the Risk of Death with Season of Diagnosis and Latitude....Pages 43-54 Optimal Serum 25-Hydroxyvitamin D Levels for Multiple Health Outcomes....Pages 55-71 Ultraviolet Exposure Scenarios: Risks of Erythema from Recommendations on Cutaneous Vitamin D Synthesis....Pages 72-85 At What Time Should One Go Out in the Sun?....Pages 86-88 Epidemiology of Melanoma and Nonmelanoma Skin Cancer—The Role of Sunlight....Pages 89-103 Ultraviolet Radiation and Malignant Melanoma....Pages 104-116 Solar UV Exposure and Mortality from Skin Tumors....Pages 117-124 Health Initiatives for the Prevention of Skin Cancer....Pages 125-136 Sunscreens....Pages 137-161 UV Damage and DNA Repair in Malignant Melanoma and Nonmelanoma Skin Cancer....Pages 162-178 Role of Viruses in the Development of Squamous Cell Cancer and Melanoma....Pages 179-186 Melanoma and Nonmelanoma Skin Cancers and the Immune System....Pages 187-202 Solar UV-Radiation, Vitamin D and Skin Cancer Surveillance in Organ Transplant Recipients (OTRs)....Pages 203-214 Histology of Melanoma and Nonmelanoma Skin Cancer....Pages 215-226 Cytogenetics of Melanoma and Nonmelanoma Skin Cancer....Pages 227-240 Molecular Biology of Basal and Squamous Cell Carcinomas....Pages 241-251 Molecular Biology of Malignant Melanoma....Pages 252-264 p53 Protein and Pathogenesis of Melanoma and Nonmelanoma Skin Cancer....Pages 265-282 Apoptosis and Pathogenesis of Melanoma and Nonmelanoma Skin Cancer....Pages 283-295 Treatment of Melanoma and Nonmelanoma Skin Cancer....Pages 296-318 Back Matter....Pages 319-323 The goal of this volume is to offer a highly readable and comprehensive overview on our present knowledge of the positive and negative effects of UV-exposure. The book focuses on vitamin D and skin cancer. Topics that are discussed in-depth by leading researchers and clinicians range from the newest findings in endocrinology, epidemiology, histology, photobiology, immunology, cytogenetics and molecular pathology to new concepts for prophylaxis and treatment.