Subcellular biochemistry. Volume 28, Cholesterol : its functions and metabolism in biology and medicine

Experts investigate the biochemical and biomedical aspects of cholesterol, addressing its metabolism in normal and disease states. They discuss a broad range of topics, including key steps in the cholesterol biosynthetic pathway, and the role of cholesterol in cancer, atherosclerosis, and diseases of the nervous system. The book's comprehensive coverage also includes the pathological consequences and potential therapies for various disease states, and the development of new anti-atherogenic drugs. Front Matter....Pages i-xxviii Signaling Molecules Derived from the Cholesterol Biosynthetic Pathway....Pages 1-21 Coordinate Regulation of Cholesterol 7α-Hydroxylase and HMG-CoA Reductase in the Liver....Pages 23-55 Polyprenyl Diphosphate Synthases....Pages 57-87 Antifungal Sterol Biosynthesis Inhibitors....Pages 89-116 The Smith—Lemli—Opitz Syndrome: A Potentially Fatal Birth Defect Caused by a Block in the Last Enzymatic Step in Cholesterol Biosynthesis....Pages 117-144 Has Nature Designed the Cholesterol Side Chain for Optimal Interaction with Phospholipids?....Pages 145-171 Cholesterol and Myelin....Pages 173-204 Regulation of Mitochondrial Cholesterol Metabolism....Pages 205-234 Lipoproteins and Cellular Cholesterol Homeostasis....Pages 235-276 Cholesterol-Sphingomyelin Interactions in Cells—Effects on Lipid Metabolism....Pages 277-293 Mechanisms and (Patho)Physiological Significance of Biliary Cholesterol Secretion....Pages 295-318 Cholesterol Deposition in Atherosclerotic Lesions....Pages 319-362 Cholesterol Metabolism and Tumor Cell Proliferation....Pages 363-435 Biological Implications of the Niemann-Pick C Mutation....Pages 437-451 Sitosterolemia....Pages 453-476 Cholesterol Cytochemistry in Cell Biology and Disease....Pages 477-505 Approaches for the Design of Novel Anti-Atherogenic Compounds....Pages 507-539 Back Matter....Pages 541-548 Signaling Molecules Derived From The Cholesterol Biosynthetic Pathway -- Coordinate Regulation Of Cholesterol 7a-hydroxylase And Hmg-coa Reductase In The Liver -- Polyprenyl Diphosphate Synthases -- Antifungal Sterol Biosynthesis Inhibitors -- The Smith-lemli-opitz Syndrome: A Potentially Fatal Birth Defect Caused By A Block In The Last Enzymatic Step In Cholesterol Biosynthesis -- Has Nature Designed The Cholesterol Side Chain For Optimal Interaction With Phospholipids? -- Cholesterol And Myelin -- Regulation Of Mitochondrial Cholesterol Metabolism -- Lipoproteins And Cellular Cholesterol Homeostasis -- Cholesterol-sphingomyelin Interactions In Cells - Effects On Lipid Metabolism -- Mechanisms And (patho)physiological Significance Of Biliary Cholesterol Secretion -- Cholesterol Deposition In Atherosclerotic Lesions -- Cholesterol Metabolism And Tumor Cell Proliferation -- Biological Implications Of The Niemann-pick C Mutation -- Sitosterolemia -- Cholesterol Cytochemistry In Cell Biology And Disease -- Approaches For The Design Of Novel Anti-atherogenic Compounds -- Index. Edited By Robert Bittman. Includes Bibliographical References And Index.