Studies of Rheumatoid Disease : Proceedings of the Third Conference on Research in the Rheumatic Diseases Toronto, February 25-27, 1965

This publication is derived from the proceedings of the Third Canadian Conference on Research in the Rheumatic Diseases, sponsored jointly by the Canadian Rheumatism Association (the professional organization) and The Canadian Arthritis and Rheumatism Society (the voluntary association). Like the previous conferences on Research in Rheumatic Diseases held in 1955 and 1960, this gathering served as a meeting ground for the exchange of information and the re-examination of the correlations suggested by the observations gathered and arranged by investigators using differing tools and hypothetical methods. Preface 5 Contents 9 PART I. MORPHOLOGICAL STUDIES AND EXPERIMENTAL ARTHRITIS 15 Morphologic Methods in the Investigation of Rheumatic Diseases: The Pathogenesis of Rheumatoid Arthritis 15 Electron Microscopic Studies of Normal Guinea-Pig Synovium 31 The Fine Structure of Rheumatoid Svnovial Membrane 38 The Pathological Changes in Articular Cartilage Associated with Persistent Joint Deformity: An Experimental Investigation 45 The Effect of Papain in Predisposing to Suppurative Arthritis 60 Experimental Production of Articular Lesions Resembling Those of the Shwartzman Reaction 68 PART II. THE IMMUNOGLOBULINS 73 Enzymic Fragments of Human Immunoglobulin 73 Serum and Urinary Gamma Globulins in Rheumatoid Arthritis 82 Evidence of Abnormalities in the General Metabolism of Amino Acids in Rheumatoid Arthritis and Ankylosing Spondylitis 91 The Separation of Soluble Antigen-Antibody Complexes from Serum 109 PART III. LYSOSOMES AND INFLAMMATION 121 The Lysosomal Concept: Role in Connective Tissue Disease 121 In Vivo and In Vitro Studies on the Role of PMN Leucocyte Granules in Immediate Hypersensitivity 128 Platelet Aggregation, Phagocytosis, and Vessel Permeability 146 Skin Window Studies in Rheumatoid Arthritis 155 Gamma-Globulin-Induced Synovitis: Studies on the Pathogenesis of Rheumatoid Joint Inflammation 159 PART IV. OTHER STUDIES IN AETIOLOGY 167 Searches for an Infective Agent in Human Arthritis 167 Tryptophan Metabolism and Rheumatoid Arthritis 171 PART V. IMMUNE MECHANISMS 183 An Electron Microscopic Study of the Skin Lesions of Experimental Delayed Hypersensitivity 183 The Organ and Species Distribution of the Hepatocellular Antigens of the Rabbit 190 Studies on the Pathogenesis of the Liver Lesions in Runt Disease 194 Evidence for Separate Control of Haemopoietic and Immunologic Functions in the Mouse 201 Studies on the In Vivo Handling of the Third Component of Complement 210 A Complement and Antigen Defect in Certain Inbred Strains of Mice: An Instance of Eniotypy 214 PART VI. CONNECTIVE TISSUE BIOCHEMISTRY 235 Brief Survey of the Biochemistry of Connective Tissues 235 A Picture of the Breakdown of Elastin under the Action of Elastase 243 Separation of the Fluorescent Components of Elastin 248 Effects of Ultraviolet Irradiation on Human and Bovine Collagen and Elastin: Relationship of Tyrosine to Native Fluorescence 258 Comparison of Elastins from Various Sources 267 The Biosynthesis of Bovine Submaxillary Mucin 271 Effect of Inhibitors of Protein Synthesis on the Plasma Seromucoid and Haptoglobin Levels of Rats during Inflammation 280 PART VII. CLINICAL STUDIES AND METHODS OF THERAPY 289 Involvement of the Pulmonary Parenchyma in Rheumatoid Arthritis 289 Rheumatoid Pleural and Pulmonary Disease 292 Studies on the Anti-Inflammatory Activity of Alkoxyglycerols in Rats 298 The Effect of Chelation Therapy on Rheumatoid Arthritis 305 Alteration of Some Laboratory Tests in Patients Receiving Norethynodrel (Enovid) for the Treatment of Rheumatoid Arthritis 312 The Treatment of Persistent Knee Effusions with Intra-Articular Radioactive Gold 319 Effect of Short-Term Glucocorticoid Administration on Pituitary—Adrenal Function 322 New Concepts in Bracing and Splinting 323 The Treatment of Rheumatoid Arthritis in a Rehabilitation Hospital: Results of a Staged Programme 326 Index of Authors 333