Structure and Function of the Neural Cell Adhesion Molecule NCAM (Advances in Experimental Medicine and Biology Book 663)

Adhesive interactions are important for cell trafficking, differentiation, function and tissue formation. In the nervous system, many cell adhesion molecules (CAMs) are involved in migration of neuroblasts, outgrowth and fasciculation of neuronal processes, formation of synapses and rearrangements of synaptic contacts associated with plasticity including learning and memory. More than eighty CAMs were found to be localized at synaptic sites, where they in a regulated manner bridge pre- and postsynaptic specializations thereby modulating synaptic function. __Structure and Function of the Neural Cell Adhesion Molecule NCAM__ describes recent developments concerning structural, functional and possible therapeutic aspects of one particular CAM, the neural cell adhesion molecule (NCAM). NCAM is one of the first identified and most studied CAMs, and this book is the first attempt to collectively summarize our current knowledge of this important cell adhesion molecule. Part I. Structure and ligands of NCAM. Structural biology of NCAM / Vladislav Soroka, Christina Kasper, Flemming M. Poulsen Extracellular protein interactions mediated by the neural cell adhesion molecule, NCAM : heterophilic interactions between NCAM and cell adhesion molecules, extracellular matrix proteins, and viruses / Janne Nielsen, Nikolaj Kulahin, Peter S. Walmod Intracelluar (i.e., Intracellular) ligands of NCAM / Bettina Büttner, Rüdiger Horstkorte Role of ATP in the regulation of NCAM function / Martin V. Hübschmann, Galina Skladchikova Part II. NCAM and plysialic acid. Polysialylation of NCAM / Herbert Hildebrandt, Martina Mühlenhoff, Rita Gerardy-Schahn Structural basis for the polysialylation of the neural cell adhesion molecule / Karen J. Colley Role of PSA-NCAM in adult neurogenesis / Eduardo Gascon, Laszlo Vutskits, Jozsef Zoltan Kiss Use of PSA-NCAM in repair of the central nervous system / Abderrahman El Maarouf, Urs Rutishauser Part III. NCAM-mediated signal transduction. Signaling pathways involved in NCAM-induced neurite outgrowth / Dorte Kornerup Ditlevsen, Kateryna Kolkova Role of the growth-associated protein GAP-43 in NCAM mediated neurite outgrowth / Irina Korshunova, Mark Mosevitsky Neural cell adhesion molecule NCAM and lipid rafts / Gro Klitgaard Povlsen, Dorte Kornerup Ditlevsen The neural cell adhesion molecule and epidermal growth factor receptor : signaling crosstalk / Gro Klitgaard Polvsen Part IV. NCAM metabolism Biosynthesis of NCAM / Kateryna Kolkova. Soluble NCAM / Thomas Secher Part V. NCAM, synapses, emotions, and memory. Role of NCAM in spine dynamics and synaptogenesis / D. Muller, P. Mendez, M. DeRoo, P. Klauser, S. Steen, and L. Poglia NCAM in long-term potentiation and learning / Barbara P. Hartz, Lars Christian B. Rønn Role of NCAM in emotion and learning / Lisa Conboy, Reto Bisaz, Kamila Markram, Carmen Sandi Part VI. NCAM in disease. NCAM in neuropsychiatric and neurodegenerative disorders / Leann H. Brennaman, Patricia F. Maness Neural cell adhesion molecule in cancer : expression and mechanisms / Silvia Zecchini, Ugo Cavallaro Part VII. Pharmacology of NCAM : NCAM mimetics. NCAM mimetic peptides : an update / Vladimir Berezin, Elisabeth Bock Synthetic NCAM-derived ligands of the fibroblast growth factor receptor / Stine Maria Hansen, Shizhong Li, Elisabeth Bock, Vladimir Berezin Dendritic spine and synapse morphological alterations induced by neural cell adhesion molecule mimetic / Michael Stewart, Victor Popov, Nikolai Medvedev, Paul Gabbott, Nicola Corbett, Igor Kraev, Heather Davies Part VIII. Orthologs and paralogs of NCAM. Fasciclin II : the NCAM ortholog in Drosophila melanogaster / Lars V. Kristiansen, Michael Hortsch The neural cell adhesion molecule NCAM2/OCAM/RNCAM, a close relative to NCAM / Nikolaj Kulahin, Peter S. Walmod Part IX. Conclusion. Honoring Dr. Elisabeth Bock / Vladimir Berezin. Front Matter....Pages i-xvi Front Matter....Pages 1-1 Structural Biology of NCAM....Pages 3-22 Extracellular Protein Interactions Mediated by the Neural Cell Adhesion Molecule, NCAM: Heterophilic Interactions Between NCAM and Cell Adhesion Molecules, Extracellular Matrix Proteins, and Viruses....Pages 23-53 Intracelluar Ligands of NCAM....Pages 55-66 NCAM and the FGF-Receptor....Pages 67-79 The Role of ATP in the Regulation of NCAM Function....Pages 81-91 Front Matter....Pages 94-94 Polysialylation of NCAM....Pages 95-109 Structural Basis for the Polysialylation of the Neural Cell Adhesion Molecule....Pages 111-126 The Role of PSA-NCAM in Adult Neurogenesis....Pages 127-136 Use of PSA-NCAM in Repair of the Central Nervous System....Pages 137-147 Front Matter....Pages 150-150 Signaling Pathways Involved in NCAM-Induced Neurite Outgrowth....Pages 151-168 Role of the Growth-Associated Protein GAP-43 in NCAM-Mediated Neurite Outgrowth....Pages 169-182 The Neural Cell Adhesion Molecule NCAM and Lipid Rafts....Pages 183-198 The Neural Cell Adhesion Molecule and Epidermal Growth Factor Receptor: Signaling Crosstalk....Pages 199-209 Front Matter....Pages 212-212 Biosynthesis of NCAM....Pages 213-225 Soluble NCAM....Pages 227-242 Front Matter....Pages 244-244 Role of NCAM in Spine Dynamics and Synaptogenesis....Pages 245-256 NCAM in Long-Term Potentiation and Learning....Pages 257-270 Role of NCAM in Emotion and Learning....Pages 271-296 Front Matter....Pages 298-298 NCAM in Neuropsychiatric and Neurodegenerative Disorders....Pages 299-317 Neural Cell Adhesion Molecule in Cancer: Expression and Mechanisms....Pages 319-333 Front Matter....Pages 336-336 NCAM Mimetic Peptides: An Update....Pages 337-353 Synthetic NCAM-Derived Ligands of the Fibroblast Growth Factor Receptor....Pages 355-372 Dendritic Spine and Synapse Morphological Alterations Induced by a Neural Cell Adhesion Molecule Mimetic....Pages 373-383 Front Matter....Pages 386-386 Fasciclin II: The NCAM Ortholog in Drosophila melanogaster ....Pages 387-401 The Neural Cell Adhesion Molecule NCAM2/OCAM/RNCAM, a Close Relative to NCAM....Pages 403-420 Front Matter....Pages 422-422 Honoring Dr. Elisabeth Bock....Pages 423-426 Back Matter....Pages 427-434