Structure and Control, 3rd Edition

Front Cover; The Enzymes Structure and Control, Volume I; Copyright Page; Contents; List of Contributors; Preface; Contents of Other Volumes; Chapter 1. X-Ray Crystallography and Enzyme Structure; I. Introduction; II. Enzyme Crystals; III. X-Ray Diffraction and Principles of Protein Structure Analysis; IV. X-Ray Diffraction Studies of Globular Macromolecules; V. Summary and Conclusions; Glossary of Symbols; Chapter 2. Chemical Modification by Active-Site-Directed Reagents; I. Nature of Affnnity Labeling and Its Relationship to Chemical Modification in General II. Modification of Serine Proteases by Active-Site-Directed ReagentsIII. Active Center Labeling of Other Enzymes by Directed Reagents; IV. Particular Usefulness of Active-Site-Directed Reagents; V. Conclusions; Chapter 3. Chemical Modification as a Probe of Structure and Function; I. Introduction; II. Principles of Chemical Modification; III. Methodology; IV. Modification as a Probe of Structure; V. Modification as a Probe of Function; VI. Other Uses of Chemical Modification; VII. Discussions of Specific Enzymes; VIII. Conclusions; Chapter 4. Multienzyme Complexes; I. Introduction II. a-Ketoacid Dehydrogenase ComplexesIll. Fatty Acid Synthetases; IV. Multienzyme Complexes in the Biosynthesis of Aromatic Amino Acids; V. Biological Significance of Multienzyme Complexes; Chapter 5. Genetic Probes of Enzyme Structure; I. Introduction; II. Genes and Mutations; III. Specific Examples of Mutationally Altered Proteins; IV. Amino Acid Analogs; V. Advantages and Limitations of Mutants; Chapter 6. Evolution of Enzymes; I. General Considerations-Evolutionary and Structure-Function Relationships in Proteins; II. Some Principles from the Study of Cytochrome c III. Expressions of Genetic Phenomena in Protein StructureIV. Expression of Evolutionary Factors in Protein Structure; Chapter 7. The Molecular Basis for Enzyme Regulation; I. Introduction; II. Qualitative Features of Molecular Models; III. Quantitative Molecular Parameters for Regulatory Proteins; IV. Diagnostic Tests; V. Molecular Properties of Allosteric Proteins; VI. Conclusions; VII. Glossary; Chapter 8. Mechanisms of Enzyme Regulation in Metabolism; I. Introduction; II. Principles of Metabolic Regulation; III. Regulation of Balance between Metabolic Functions IV. Feedback Regulation of Multifunctional PathwaysChapter 9. Enzvmes as Control Elements in Metu bolic Regulation; I. Introduction; II. Analogy between Metabolic and Electronic Systems; III. Physiological Function and Design Requirements; IV. Summary; Author Index; Subject Index Content: Advisory Board Page ii Edited by Page iii Copyright page Page iv List of Contributors Page ix Preface Pages xi-xii Paul D. Boyer 1 X-Ray Crystallography and Enzyme Structure Original Research Article Pages 1-89 David Eisenberg 2 Chemical Modification by Active-Site-Directed Reagents Original Research Article Pages 91-146 Elliott Shaw 3 Chemical Modification as a Probe of Structure and Function Original Research Article Pages 147-211 Louis A. Cohen 4 Multienzyme Complexes Original Research Article Pages 213-240 Lester J. Reed, David J. Cox 5 Genetic Probes of Enzyme Structure Original Research Article Pages 241-266 Milton J. Schlesinger 6 Evolution of Enzymes Original Research Article Pages 267-339 Emil L. Smith 7 The Molecular Basis for Enzyme Regulation Original Research Article Pages 341-396 D.E. Koshland Jr. 8 Mechanisms of Enzyme Regulation in Metabolism Original Research Article Pages 397-459 E.R. Stadtman 9 Enzymes as Control Elements in Metabolic Regulation Original Research Article Pages 461-489 Daniel E. Atkinson Author Index Pages 491-516 Subject Index Pages 517-559 Front Cover; The Enzymes Structure and Control, Volume I; Copyright Page; Contents; List of Contributors; Preface; Contents of Other Volumes; Chapter 1. X-Ray Crystallography and Enzyme Structure; Chapter 2. Chemical Modification by Active-Site-Directed Reagents; Chapter 3. Chemical Modification as a Probe of Structure and Function; Chapter 4. Multienzyme Complexes; Chapter 5. Genetic Probes of Enzyme Structure; Chapter 6. Evolution of Enzymes; Chapter 7. The Molecular Basis for Enzyme Regulation; Chapter 8. Mechanisms of Enzyme Regulation in Metabolism.Chapter 9. Enzvmes as Control Elements in Metu bolic RegulationAuthor Index; Subject Index.Electronic reproduction.Available via World Wide Web.