Stress Response in Pathogenic Bacteria (Advances in Molecular and Cellular Biology Series)

The ability of pathogenic bacteria to adapt to various chemical, biochemical and physical conditions within the human host and their ability to respond to stresses generated in these environments is a central feature of infectious diseases and the outcome of bacterial infection. This book covers the key aspects of this rapidly developing field, including the generation of stresses by the host immune system, bacterial response to reactive chemicals, and adaptation to environmental conditions of anatomical niches such as the gut, mouth and urogenital tract. It also addresses the increasing importance of different metal ions in the pathogenesis and survival of specific bacteria. With chapters by active research experts in the field, the book provides a comprehensive outline of the current understanding of this field, the latest developments and where future research is likely to be directed. Contents......Page 6 Contributors......Page 8 Preface......Page 10 PART 1: OXIDATIVE AND NITROSATIVE STRESS......Page 12 1 Oxidative and Nitrosative Stress Defence Systems in Escherichia coli and Pseudomonas aeruginosa: A Model Organism of Study Versus a Human Opportunistic Pathogen......Page 14 2 Coordinated Regulation of Stress and Virulence Adaptations in Stages of Haemophilus Pathogenesis......Page 44 3 Nitric Oxide Stress in Escherichia coli and Salmonella......Page 59 4 Nitric Oxide and Gram-positive Pathogens: Host Triggers and Bacterial Defence Mechanisms......Page 79 PART 2: NOVEL GENE REGULATION IN RESPONSE TO HOST DEFENCES......Page 102 5 Novel Regulation in Response to Host-generated Stresses: The MerR Family of Regulators in Pathogenic Bacteria......Page 104 6 Stress Responses in the Pathogenic Neisseria: Overlapping Regulons and sRNA Regulation......Page 126 PART 3: ACID STRESS, PH CONTROL AND SURVIVAL IN THE HUMAN HOST......Page 144 7 Acid Survival Mechanisms of Bacterial Pathogens of the Digestive Tract......Page 146 8 Urease and the Bacterial Acid Stress Response......Page 178 PART 4: NUTRIENT STRESS......Page 194 9 Secretion Systems and Metabolism in the Pathogenic Yersiniae......Page 196 10 Response of Neisseria gonorrhoeae to Oxygen Limitation and Excess......Page 232 PART 5: METAL LONS AND PATHOGENIC BACTERLA......Page 254 11 Copper and Zinc Stress in Bacteria......Page 256 12 Metal Ion Sensing in Mycobacterium tuberculosis......Page 277 13 Salmonella and the Host in the Battle for Iron......Page 294 A......Page 308 D......Page 309 G......Page 310 I......Page 311 M......Page 312 O......Page 313 Q......Page 314 S......Page 315 T......Page 316 Z......Page 317 Contents 6 Contributors 8 Preface 10 PART 1: OXIDATIVE AND NITROSATIVE STRESS 12 1 Oxidative and Nitrosative Stress Defence Systems in Escherichia coli and Pseudomonas aeruginosa: A Model Organism of Study Versus a Human Opportunistic Pathogen 14 2 Coordinated Regulation of Stress and Virulence Adaptations in Stages of Haemophilus Pathogenesis 44 3 Nitric Oxide Stress in Escherichia coli and Salmonella 59 4 Nitric Oxide and Gram-positive Pathogens: Host Triggers and Bacterial Defence Mechanisms 79 PART 2: NOVEL GENE REGULATION IN RESPONSE TO HOST DEFENCES 102 5 Novel Regulation in Response to Host-generated Stresses: The MerR Family of Regulators in Pathogenic Bacteria 104 6 Stress Responses in the Pathogenic Neisseria: Overlapping Regulons and sRNA Regulation 126 PART 3: ACID STRESS, PH CONTROL AND SURVIVAL IN THE HUMAN HOST 144 7 Acid Survival Mechanisms of Bacterial Pathogens of the Digestive Tract 146 8 Urease and the Bacterial Acid Stress Response 178 PART 4: NUTRIENT STRESS 194 9 Secretion Systems and Metabolism in the Pathogenic Yersiniae 196 10 Response of Neisseria gonorrhoeae to Oxygen Limitation and Excess 232 PART 5: METAL LONS AND PATHOGENIC BACTERLA 254 11 Copper and Zinc Stress in Bacteria 256 12 Metal Ion Sensing in Mycobacterium tuberculosis 277 13 Salmonella and the Host in the Battle for Iron 294 Index 308 A 308 B 309 C 309 D 309 E 310 F 310 G 310 H 311 I 311 K 312 L 312 M 312 N 313 O 313 P 314 Q 314 R 315 S 315 T 316 U 317 V 317 W 317 Y 317 Z 317 9781845937607 CABI Oxidative and nitrosative stress defence systems in escherichia coli and pseudomonas aeruginosa : a model organism of study versus a human opportunistic pathogen / by James A. Imlay and Daniel J. Hassett Coordinated regulation of stress and virulence adaptations in stages of haemophilus pathogenesis / by Sandy M. S. Wong and Brain J. Akerley Nitric oxide stress in escherichia coli and salmonella / by Stephen Spiro Nitric oxide and gram-positive pathogens : host triggers and bacterial defence mechanisms / by Glen C. Ulett and Adam J. Potter Novel regulation in response to host generated stresses : the Merr family of regulators in pathogenic bacteria / by Stephen P. Kidd Stress responses in pathogenic neisseria : overlapping regulons and SRNA regulation / by Stuart A. Hill Acid survival mechanisms of bacterial pathogens of the digestive tract / by Hanan Gancz and D. Scott Merrell Urease and the bacterial acid stress response / by Peter Chivers Secretion systems and metabolism in pathogenic yersiniae / by Matthew S. Francis Response of neisseria gonorrhoeae to oxygen limitation and excess / by Jeffery A. Cole Copper and zinc stress in bacteria / by Selina R. Clayton, Karin Heurlier, Taku Oshim, and Jon. L. Hobman Metal ion sensing in mycobacterium tuberculosis / by Jennifer S. Cavet Salmonella and the host in the battle for iron by Elisa Deriu, Janet Z. Liu and Manuela Raffatellu.