Stress Hormones and Post Traumatic Stress Disorder:, Volume 167: Basic Studies and Clinical Perspectives (Progress in Brain Research) (Progress in Brain Research)

Post-traumatic stress disorder (PTSD) arises from the experience of severe stressors and trauma. The disorder is characterized by recurrent recall of intrusive memories to the event, nightmares with insomnia, emotional numbing, hyperarousal, which are all long-lasting and relatively resistant to therapy. The focus of this book is on the question of how stress hormones are involved in PTSD. Recent evidence suggests that a dysregulation in stress hormones promotes the precipitation of PTSD and that correction of these hormones may ameliorate the disorder. This book combines state-of-the-art basic research on stress hormones from gene to behaviour with clinical research demonstrating the progress in understanding via imaging techniques, genetics, vulnerable phenotypes and co-morbidity with other disorders and physical illness. Content: List of contributors Pages v-viii Preface Pages ix-xi E. Ronald de Kloet, Melly S. Oitzl, Eric Vermetten Acknowledgements Page xiii Stress-induced changes in hippocampal function Review Article Pages 3-15 Marian Joëls, Harm Krugers, Henk Karst Glucocorticoids, developmental ‘programming’ and the risk of affective dysfunction Review Article Pages 17-34 Jonathan R. Seckl Amygdala modulation of memory-related processes in the hippocampus: potential relevance to PTSD Review Article Pages 35-51 M.M. Tsoory, R.M. Vouimba, I. Akirav, A. Kavushansky, A. Avital, G. Richter-Levin Commentary: Neuroendocrine basis Review Article Pages 53-62 E.R. de Kloet Mice that under- or overexpress glucocorticoid receptors as models for depression or posttraumatic stress disorder Review Article Pages 65-77 Sabine Chourbaji, Miriam A. Vogt, Peter Gass Adrenal stress hormones, amygdala activation, and memory for emotionally arousing experiences Review Article Pages 79-97 Benno Roozendaal, Areg Barsegyan, Sangkwan Lee Adult neurogenesis and systemic adaptation: animal experiments and clinical perspectives for PTSD Review Article Pages 99-109 Noriko U. Takemura, Nobumasa Kato Commentary: Behavioral phenotype Review Article Pages 111-117 Melly S. Oitzl Transgenerational transmission of cortisol and PTSD risk Review Article Pages 121-135 Rachel Yehuda, Linda M. Bierer Early care experiences and HPA axis regulation in children: a mechanism for later trauma vulnerability Review Article Pages 137-149 Megan R. Gunnar, Karina M. Quevedo The functional neuroanatomy of PTSD: a critical review Review Article Pages 151-169 Israel Liberzon, Chandra Sekhar Sripada Structural and functional plasticity of the human brain in posttraumatic stress disorder Review Article Pages 171-186 J. Douglas Bremner, Bernet Elzinga, Christian Schmahl, Eric Vermetten Commentary: biological findings in PTSD — too much or too little? Review Article Pages 187-199 Arieh Y. Shalev, Ronen H. Segman Models of PTSD and traumatic stress: the importance of research “from bedside to bench to bedside” Review Article Pages 203-215 Robert J. Ursano, He Li, Lei Zhang, Chris J. Hough, Carol S. Fullerton, David M. Benedek, Thomas A. Grieger, Harry C. Holloway What is it that a neurobiological model of PTSD must explain? Review Article Pages 217-228 Chris R. Brewin Post-traumatic stress disorder in somatic disease: lessons from critically ill patients Review Article Pages 229-237 Gustav Schelling Glucocorticoid-induced reduction of traumatic memories: implications for the treatment of PTSD Review Article Pages 239-247 Dominique J.-F. de Quervain Commentary: synthesis and perspectives Review Article Pages 249-254 R.K. Pitman Strain specific fear behaviour and glucocorticoid response to aversive events: modelling PTSD in mice Review Article Pages 257-261 V. Brinks, E.R. de Kloet, M.S. Oitzl Interaction of endogenous cortisol and noradrenaline in the human amygdala Review Article Pages 263-268 Anda H. van Stegeren, Oliver T. Wolf, Walter Everaerd, Serge A.R.B. Rombouts Corticosteroid hormones, synaptic strength and emotional memories: corticosteroid modulation of memory — a cellular and molecular perspective Review Article Pages 269-271 Olof Wiegert, Marian Joëls, Harm J. Krugers Does trauma cause lasting changes in HPA-axis functioning in healthy individuals? Review Article Pages 273-275 Ellen R. Klaassens, Tineke van Veen, Frans G. Zitman Need for alternative ways of phenotyping of mood, anxiety, and somatoform disorders in biological research Review Article Pages 277-280 G. Veen, I.M. van Vliet, R.H. de Rijk, F.G. Zitman The HPA-axis and immune function in burnout Review Article Pages 281-285 Paula M.C. Mommersteeg, Cobi J. Heijnen, Annemieke Kavelaars, Lorenz J.P. van Doornen Elevated plasma corticotrophin-releasing hormone levels in veterans with posttraumatic stress disorder Review Article Pages 287-291 C.S. de Kloet, E. Vermetten, E. Geuze, E.G.W.M. Lentjes, C.J. Heijnen, G.K. Stalla, H.G.M. Westenberg Precuneal activity during encoding in veterans with posttraumatic stress disorder Review Article Pages 293-297 Elbert Geuze, Eric Vermetten, Carien S. de Kloet, Herman G.M. Westenberg Posttraumatic stress disorder with secondary psychotic features: neurobiological findings Review Article Pages 299-302 Mario H. Braakman, Frank A.M. Kortmann, Wim van den Brink, Robbert J. Verkes Neuroendocrine dysregulations in sexually abused children and adolescents: a systematic review Review Article Pages 303-306 I.A.E. Bicanic, M. Meijer, G. Sinnema, E.M. van de Putte, M. Olff Volume of discrete brain structures in complex dissociative disorders: preliminary findings Review Article Pages 307-310 T. Ehling, E.R.S. Nijenhuis, A.P. Krikke Epilogue Review Article Pages 311-313 Eric Vermetten Subject Index Pages 315-320