Strategies and Tactics in Organic Synthesis, Volume 4 (Strategies and Tactics in Organic Synthesis)

A classic in the area of organic synthesis, Strategies and Tactics in Organic Synthesis provides a forum for investigators to discuss their approach to the science and art of organic synthesis. Rather than a simple presentation of data or a second-hand analysis, we are given stories that vividly demonstrate the power of the human endeavour known as organic synthesis and the creativity and tenacity of its practitioners. First hand accounts of each project tell of the excitement of conception, the frustration of failure and the joy experienced when either rational thought and/or good fortune give rise to successful completion of a project. In this book we learn how synthesis is really done and are educated, challenged and inspired by these stories, which portray the idea that triumphs do not come without challenges. We also learn that we can meet challenges to further advance the science and art of organic synthesis, driving it forward to meet the demands of society, in discovering new reactions, creating new designs and building molecules with atom and step economies that provide solutions through function to create a better world. - Personal accounts of research in organic chemistry. - Written by internationally renowned scientists.- Details state of the art organic synthesis. Content: Contributors Pages xiii-xiv Foreword Pages xv-xvi Paul A. Wender Preface Pages xvii-xviii Michael Harmata Dedication Page xix Chapter 1 Methodology validation and structure correction by total synthesis: The case of the clerodane diterpenoid, sacacarin Original Research Article Pages 1-18 Robert B. Grossman, Ravindra M. Rasne Chapter 2 Total synthesis of (±)-cylindrospermopsin Original Research Article Pages 19-39 Barry B. Snider, Chaoyu Xie Chapter 3 The total synthesis of (-)-Arisugacina A Original Research Article Pages 41-70 Richard P. Hsung, Kevin P. Cole Chapter 4 Total synthesis of kainoids by dearomatizing anionic cyclization Original Research Article Pages 71-96 Jonathan Clayden Chapter 5 Total synthesis of jatrophatrione, an unprecedented [5.9.5] tricyclic antileukemic diterpene Original Research Article Pages 97-131 Leo A. Paquette Chapter 6 Alkynyliodonium salts in organic synthesis Original Research Article Pages 133-170 Ken S. Feldman Chapter 7 How to thread a string through the eye of a molecular needle: Template synthesis of interlocked molecules Original Research Article Pages 171-210 Michael Kogej, Pradyut Ghosh, Christoph A. Schalley Chapter 8 Total synthesis of spongistatin 1 (altohyrtin a): A tale of ten aldols Original Research Article Pages 211-245 Ian Paterson, Mark J. Coster Chapter 9 The ring-closing metathesis approach to fumagillol Original Research Article Pages 247-267 Jacques Eustache, Pierre Van de Weghe Chapter 10 Devising an especially efficient route to the ‘Miracle’ 1 nutrient coenzyme Q 10 Original Research Article Pages 269-292 Bruce H. Lipshutz Chapter 11 Total synthesis of lipid I and lipid II: Late-stage intermediates utilized in bacterial cell wall biosynthesis Original Research Article Pages 293-313 Michael S. VanNieuwenhze Chapter 12 Ring rearrangement metathesis (RRM) — A new concept in piperidine and pyrrolidine synthesis Original Research Article Pages 315-346 Sandeep Basra, Siegfried Blechert Chapter 13 Catalytic asymmetric total synthesis of (-)-strychnine and fostriecin Original Research Article Pages 347-363 Masakatsu Shibasaki, Motomu Kanai, Takashi Ohshima Chapter 14 The synthesis of (⇠)-strychnine via a cobalt-mediated [2 + 2 + 2]cycloaddition Original Research Article Pages 365-405 K. Peter C. Vollhardt, Michael J. Eichberg Index Pages 407-415 A classic in the area of organic synthesis, Strategies and Tactics in Organic Synthesis provides a forum for investigators to discuss their approach to the science and art of organic synthesis. Rather than a simple presentation of data or a second-hand analysis, we are given stories that vividly demonstrate the power of the human endeavour known as organic synthesis and the creativity and tenacity of its practitioners. First hand accounts of each project tell of the excitement of conception, the frustration of failure and the joy experienced when either rational thought and/or good fortune give rise to successful completion of a project.
In this book we learn how synthesis is really done and are educated, challenged and inspired by these stories, which portray the idea that triumphs do not come without challenges. We also learn that we can meet challenges to further advance the science and art of organic synthesis, driving it forward to meet the demands of society, in discovering new reactions, creating new designs and building molecules with atom and step economies that provide solutions through function to create a better world.

- Personal accounts of research in organic chemistry.
- Written by internationally renowned scientists.
- Details state of the art organic synthesis. Front Cover; Strategies and Tactics in Organic Synthesis; Copyright Page; CONTENTS; CONTRIBUTORS; FOREWORD; PREFACE; DEDICATION; CHAPTER 1. METHODOLOGY VALIDATION AND STRUCTURE CORRECTION BY TOTAL SYNTHESIS: THE CASE OF THE CLERODANE DITERPENOID, SACACARIN; CHAPTER 2. TOTAL SYNTHESIS OF (℗ł)-CYLINDROSPERMOPSIN; CHAPTER 3. THE TOTAL SYNTHESIS OF ( )-ARISUGACIN A.; CHAPTER 4. TOTAL SYNTHESIS OF KAINOIDS BY DEAROMATIZING ANIONIC CYCLIZATION; CHAPTER 5. TOTAL SYNTHESIS OF JATROPHATRIONE, AN UNPRECEDENTED [5.9.5] TRICYCLIC ANTILEUKEMIC DITERPENE. Presents stories that demonstrate the power of the human endeavour known as organic synthesis and the creativity and tenacity of its practitioners. This work helps us learn how synthesis is really done and are educated, challenged and inspired by these stories, which portray the idea that triumphs do not come without challenges. Scientists who pursue the total synthesis of natural products may choose a target compound for several reasons.