Stories of Success, Volume 46: Personal Recollections XI (Comprehensive Biochemistry)

This volume, like previous Volumes 35-44, will include historical and autobiographical perspectives of the developments in the field through the contributions of leading individuals who reflect on their careers and their impact on biochemistry. * Contributors are distinguished scientists in the field * Unique series of personal recollections * Presents scientific research in a historical perspective Comprehensive biochemistry......Page 1 Elsevier......Page 2 Preface to volume 46......Page 3 References......Page 5 Contributors to this volume......Page 6 Half a Century Later and, Still, I’m Not Disenchanted with Science......Page 8 Instead of a Preface......Page 9 My Parents......Page 10 Fate of the Family During the War, 1941-1945......Page 15 After the War. The ‘‘Doctor’s Plot.’’ The Death of Stalin......Page 28 School Life......Page 31 University: Student Community and Lysenko......Page 35 Linus Pauling Visits Moscow University......Page 45 The Engelhardt’s Institute: First Years......Page 46 A Digression from Biochemistry into the Physics of Biopolymers......Page 58 Macromolecular Structure of Transfer RNA in Solution......Page 60 Aminoacyl-tRNA Synthetases......Page 61 The Role of Anticodon in the Second Genetic Code......Page 63 IUB Congress in New York: The First Trip Abroad......Page 65 Visits to France, 1967 and 1974......Page 73 The Revertase Project: Deviation from the Mainstream......Page 80 Russian Version of the Human Genome Project......Page 82 Paris Once More hellip......Page 84 Termination Translation in Eukaryotes: Last Love?......Page 88 Human Frontiers Science Program: Intercontinental Cooperation......Page 98 Editorial Activities......Page 99 Scientific Research as a Source of Optimism......Page 101 Acknowledgments......Page 106 Russian journals Biokhimiya and Molekularnaya Biologiya are available in English. Although the volumes and years coincide in both versions, the page numbers differ. Here they are given for Russian edition if not specified otherwise.......Page 107 A Farewell......Page 120 The Pathway to the Institut Pasteur: Chance or Destiny......Page 121 The Pathway to Protein Folding......Page 144 A Detour Through Molecular Enzymology: The Catalytic Mechanism of Tryptophan Synthase......Page 152 Back and Deep into Protein Folding: The ‘‘Globule’’ Model......Page 165 Without Monsieur Monod: Globules, Molten Globules, and the Tryptophan Synthase Folding Pathway......Page 176 From Molten Globules to Pre-Molten Globules......Page 181 Probing the Conformation of Proteins and Folding Intermediates with Monoclonal Antibodies......Page 184 Analogies between the Folding Mechanisms of Tryptophan Synthase and other Proteins......Page 191 From Aggregates to Prions: Back to Early Concerns......Page 199 My Proteinless Studies......Page 215 Administration and Transmission of Science......Page 222 Concluding Remarks......Page 230 References......Page 233 Explosive Extracellular Matrix Research from 1960 to 2000. A Personal Recollection of the Work Pioneered by Rupert Timpl......Page 237 Biographical Notes......Page 238 Training in Chemistry and First Contacts with Biology......Page 241 The State of the Art of Matrix Research in the 1960s......Page 243 From Immunology to the Complexity and Structure of the Extracellular Matrix......Page 245 The Basement Membrane Proteins Collagen IV and the Discovery of Laminin......Page 249 Discovery of Laminin’s Cell Biological Activities......Page 252 Basement Membrane Proteoglycans......Page 254 Nidogen/Entactin, Collagen VI, and BM-40/SPARC......Page 255 Ringberg and Other Meetings......Page 257 Domains and Interacting Proteins at Atomic Resolution......Page 260 Promotion to Scientific Member of the Max-Planck-Society and the arrival of Takako Sasaki......Page 262 Cellular Receptors for Matrix Proteins......Page 265 Collagen XVIII and Endostatin......Page 266 The Last Years......Page 268 The Memorial Symposium, a Summary and Outlook......Page 270 References......Page 274 A Life with Yeast Molecular Biology......Page 280 My Early Years and Education......Page 281 Institute of Genetics and tRNA......Page 290 Institute of Physiological Chemistry in Munich tRNA Biogenesis......Page 296 Yeast tRNA Genes and Ty Elements......Page 300 The Yeast Genome Project......Page 307 Yeast 26S Proteasome and Triple A Proteins......Page 310 Administration and Teaching Medical Students......Page 313 FEBS......Page 314 Spetses Summer Schools......Page 320 Gene Technology......Page 322 Sonderforschungsbereich 190......Page 324 Other Encounters......Page 325 Epilogue......Page 326 Acknowledgment......Page 328 References......Page 329 A Botanist Going Astray: 77 Semesters of Studying Membrane Transport and Protein Glycosylation......Page 339 Youth and Eight Semesters of Studies in Munich......Page 340 My PhD Work at Purdue University......Page 343 Back in Munich: ‘‘Wissenschaftlicher Assistent’’ and Finding my Own Way......Page 344 University/German Science Advisory Board/DFG......Page 350 The Dichotomy of Basic Science in Germany: Universities Versus Max-Planck Institutes......Page 355 My Excursion into Real Botany......Page 358 An Inducible Active Transport System in a Eukaryotic Cell......Page 363 The Membrane Potential......Page 368 Transport Kinetics plus/minus Protons......Page 369 Can the Transport Protein also Act as a Facilitator?......Page 372 Cloning the Gene Coding for the Hexose Uptake Protein (HUP1)......Page 373 Structure/Function Relationships in HUP1......Page 374 In vitro Transport Tests and HUP1 Protein Purification......Page 375 Over 40 Years of Membrane Transport Proteins: How about the Role of Lipids?......Page 377 Rafts or Raft Clusters or a New Type of Plasma Membrane Micro-Domains......Page 379 Biochemistry and Molecular Biology......Page 381 Functional Aspects of Protein Glycosylation......Page 387 Balance Sheet and Outlook......Page 390 References......Page 391 Viktor Mutt: A Giant in the Field of Bioactive Peptides......Page 401 Early Days......Page 402 Secretin......Page 406 The Post-Secretin Period......Page 409 Viktor: Teacher, Scientist, and Friend......Page 412 Conclusions......Page 416 References......Page 417 Sailing Side by Side......Page 421 BMJ and HJ: About this Chapter......Page 422 HJ: Growing Up in the Orbit of Chemistry......Page 423 BMJ: The Roots: Memories from an Uneventful Childhood......Page 427 HJ: Too Many Years of Lessons and Lectures......Page 428 BMJ: Education in Science......Page 432 HJ: Everybody Should have been to Tuumlbingen......Page 436 HJ: Ending Halfway up the Hill......Page 440 BMJ: A Munich-Tuumlbingen Connection......Page 441 HJ: In the Dungeons: From Phytopathology to Protein Stability......Page 442 BMJ: From Ant Lions to Pond Snails......Page 452 BMJ and HJ: From the East Coast to the Midwest, by Beetle......Page 455 HJ: ‘‘Harold from Biophysics’’......Page 459 BMJ: An Acellular Model of the Cancer Cell......Page 461 HJ and BMJ: Founding a Family in Good Old Tübingen......Page 463 HJ: From Virus to Mould......Page 464 BMJ: Would a Slime Mould Thrive at Tuumlbingen?......Page 467 HJ: ‘‘hellip zum Städtele hinaus’’ - Leaving Tübingen for Good......Page 469 HJ: Changing Fields Again......Page 470 BMJ: From Slime Mould to Vertebrate Cells......Page 472 HJ: Down the Rhine: From Basel to Heidelberg......Page 474 HJ and BMJ: On the Move Again......Page 475 BMJ: A Step up the Hill: EMBL at Heidelberg......Page 476 HJ: Brain and Muscle......Page 480 BMJ and HJ: Settling the Family up North......Page 482 HJ: ‘‘Where is Bielefeld?’ - From Mouse to Man......Page 484 BMJ: Making the Best of it: Bielefeld University......Page 495 HJ: Cytoskeletal Diseases of Muscle......Page 499 BMJ: The last Bielefeld Years: Research and Science Politics......Page 510 HJ: Genes, Chromosomes, and Sick Neurons......Page 516 BMJ: Greener Pastures in Lower Saxony......Page 525 HJ: The Resurrection of TMV......Page 526 BMJ: Research at the ‘‘Carolo Wilhelmina’’......Page 527 HJ: Morphogenesis and a Bit of Mathematics......Page 540 BMJ and HJ: Returning to Southern Germany......Page 543 HJ: Shop Closed, Business Continues......Page 544 BMJ: Closing the Circle......Page 546 HJ and BMJ: Special Places, Special People......Page 548 HJ and BMJ: A Privileged Life......Page 554 References......Page 555 Abbreviations and Symbols......Page 567 Technical Information Relating to HJ......Page 568 sdarticle_011.pdf......Page 569 This book is the latest volume in the highly successful series Comprehensive Biochemistry. It provides a historical and autobiographical perspective of the developments in the field through the contributions of leading individuals who reflect on their careers and their impact on biochemistry. Volume 46 is essential reading for everyone from graduate student to professor, placing in context major advances not only in biochemical terms but in relation to historical and social developments. Readers will be delighted by the lively style and the insight into the lives and careers of leading scientists of their time.

* Contributors are distinguished scientists in the field
* Unique series of personal recollections
* Presents scientific research in a historical perspective This volume, like previous Volumes 35-45, will include historical and autobiographical perspectives of the developments in the field through the contributions of leading individuals who reflect on their careers and their impact on biochemistry