Stem Cells & Regenerative Medicine: From Molecular Embryology to Tissue Engineering (Stem Cell Biology and Regenerative Medicine)

Defined as, "(BThe science about the development of an embryo from the fertilization of the ovum to the fetus stage," embryology has been a mainstay at universities throughout the world for many years. Throughout the last century, embryology became overshadowed by experimental-based genetics and cell biology, transforming the field into developmental biology, which replaced embryology in Biology departments in many universities. Major contributions in this young century in the fields of molecular biology, biochemistry and genomics were integrated with both embryology and developmental biology to provide an understanding of the molecular portrait of a "(Bdevelopment cell." That new integrated approach is known as stem-cell biology; it is an understanding of the embryology and development together at the molecular level using engineering, imaging and cell culture principles, and it is at the heart of this seminal book. Stem Cells and Regenerative Medicine: From Molecular Embryology to Tissue Engineering is completely devoted to the basic developmental, cellular and molecular biological aspects of stem cells as well as their clinical applications in tissue engineering and regenerative medicine. It focuses on the basic biology of embryonic and cancer cells plus their key involvement in self-renewal, muscle repair, epigenetic processes, and therapeutic applications. In addition, it covers other key relevant topics such as nuclear reprogramming induced pluripotency and stem cell culture techniques using novel biomaterials. A thorough introduction to stem-cell biology, this reference is aimed at graduate students, post-docs, and professors as well as executives and scientists in biotech and pharmaceutical companies Front Matter....Pages i-xxvii Front Matter....Pages 1-1 Introduction to Stem Cells and Regenerative Medicine....Pages 3-18 Embryonic Stem Cells: Discovery, Development, and Current Trends....Pages 19-43 Bmi1 in Self-Renewal and Homeostasis of Pancreas....Pages 45-57 Cancer Stem Cells in Solid Tumors....Pages 59-76 Adipose-Derived Stem Cells and Skeletal Muscle Repair....Pages 77-87 Regeneration of Sensory Cells of Adult Mammalian Inner Ear....Pages 89-101 Stem Cells and Their Use in Skeletal Tissue Repair....Pages 103-124 Front Matter....Pages 125-125 Epigenetic Identity in Cancer Stem Cells....Pages 127-139 Function of MicroRNA-145 in Human Embryonic Stem Cell Pluripotency....Pages 141-153 Mesenchymal Stem Cells for Liver Regeneration....Pages 155-179 Front Matter....Pages 193-193 The Role of Time-Lapse Microscopy in Stem Cell Research and Therapy....Pages 181-191 Therapeutic Applications of Mesenchymal Stem/Multipotent Stromal Cells....Pages 195-218 Gastrointestinal Stem Cells....Pages 219-225 Lung Epithelial Stem Cells....Pages 227-241 Placental-Derived Stem Cells: Potential Clinical Applications....Pages 243-263 Bone Marrow Cell Therapy for Acute Myocardial Infarction: A Clinical Trial Review....Pages 265-277 Stem Cell Transplantation to the Heart....Pages 279-297 Adult Neural Progenitor Cells and Cell Replacement Therapy for Huntington Disease....Pages 299-314 Migration of Transplanted Neural Stem Cells in Experimental Models of Neurodegenerative Diseases....Pages 315-336 Prospects for Neural Stem Cell Therapy of Alzheimer Disease....Pages 337-348 Front Matter....Pages 349-349 Nuclear Transfer Embryonic Stem Cells as a New Tool for Basic Biology....Pages 351-369 Pluripotent Stem Cells in Reproductive Medicine: Formation of the Human Germ Line in Vitro ....Pages 371-386 Prospects for Induced Pluripotent Stem Cell Therapy for Diabetes....Pages 387-398 Keratinocyte-Induced Pluripotent Stem Cells: From Hair to Where?....Pages 399-411 Generation and Characterization of Induced Pluripotent Stem Cells from Pig....Pages 413-425 Induced Pluripotent Stem Cells: On the Road Toward Clinical Applications....Pages 427-438 Direct Reprogramming of Human Neural Stem Cells by the Single Transcription Factor OCT4....Pages 439-447 Front Matter....Pages 449-449 Stem Cells and Biomaterials: The Tissue Engineering Approach....Pages 451-464 Microtechnology for Stem Cell Culture....Pages 465-482 Using Lab-on-a-Chip Technologies for Stem Cell Biology....Pages 483-498 The Development of Small Molecules and Growth Supplements to Control the Differentiation of Stem Cells and the Formation of Neural Tissues....Pages 499-513 Long-Term Propagation of Neural Stem Cells: Focus on Three-Dimensional Culture Systems and Mitogenic Factors....Pages 515-538 Front Matter....Pages 539-539 Stem Cells and Regenerative Medicine in Urology....Pages 541-564 Muscle-Derived Stem Cells: A Model for Stem Cell Therapy in Regenerative Medicine....Pages 565-578 Regenerative Strategies for Cardiac Disease....Pages 579-593 Collecting, Processing, Banking, and Using Cord Blood Stem Cells for Regenerative Medicine....Pages 595-614 Back Matter....Pages 615-629 Pt. 1. Stem cell biology pt. 2. Epigenetic and microRNA regulation in stem cells pt. 3. Stem cells for therapeutic applications pt. 4. Nuclear reprogramming and induced pluripotent stem cells pt. 5. Tissue engineering pt. 6. Regenerative medicine.