Stem Cells, Pre-neoplasia, and Early Cancer of the Upper Gastrointestinal Tract (Advances in Experimental Medicine and Biology Book 908)

This book is a comprehensive understanding of the evolution of pre-malignant disease, emphasizing common themes in the field, including stem cell biology and histologic modes of cancer progression between the distal esophagus and stomach. Its sixteen chapters discuss metaplastic tissue change in the upper GI, clonalexpansion of early neoplasia, stem cell dynamics in experimental models, pathology of early esophageal squamous cell carcinoma, therapeutic modalities for esophageal squamous cell carcinoma, pathology of Barrett’s esophagus, screening, early detection and novel diagnostic tools for Barrett's esophagus, clonal evolution of Barrett’s esophagus, endoscopic therapeutic modalities of early esophageal cancer, pathology of early gastric cancer, and experimental models for gastric cancer. __Stem Cells, Pre-neoplasia and Early Cancer of the Upper Gastrointestinal Tract__ is an integrative text on both the current state of translational research on every cancer development of the upper gastrointestinal tract as well as on novel clinical diagnostic and therapeutic modalities. It highlights a rapidly growing field within cancer research and is essential reading for oncologists, biochemists and advanced graduate students alike. Springer’s __Advances in Experimental Medicine and Biology__ series presents multidisciplinary and dynamic findings in the broad fields of experimental medicine and biology. The wide variety in topics it presents offers readers multiple perspectives on a variety of disciplines including neuroscience, microbiology, immunology, biochemistry, biomedical engineering and cancer research. Front Matter....Pages i-xii Distal Esophageal Adenocarcinoma and Gastric Adenocarcinoma: Time for a Shared Research Agenda....Pages 1-8 Front Matter....Pages 9-9 Clonal Evolution of Stem Cells in the Gastrointestinal Tract....Pages 11-25 The Complex, Clonal, and Controversial Nature of Barrett’s Esophagus....Pages 27-40 A New Pathologic Assessment of Gastroesophageal Reflux Disease: The Squamo-Oxyntic Gap....Pages 41-78 Front Matter....Pages 79-79 Diagnosis by Endoscopy and Advanced Imaging of Barrett’s Neoplasia....Pages 81-98 Endoscopic Treatment of Early Barrett’s Neoplasia: Expanding Indications, New Challenges....Pages 99-109 Definition, Derivation, and Diagnosis of Barrett’s Esophagus: Pathological Perspectives....Pages 111-136 What Makes an Expert Barrett’s Histopathologist?....Pages 137-159 Staging Early Esophageal Cancer....Pages 161-181 Transcommitment: Paving the Way to Barrett’s Metaplasia....Pages 183-212 Studying Cancer Evolution in Barrett’s Esophagus and Esophageal Adenocarcinoma....Pages 213-236 Genomics of Esophageal Cancer and Biomarkers for Early Detection....Pages 237-263 Common Variants Confer Susceptibility to Barrett’s Esophagus: Insights from the First Genome-Wide Association Studies....Pages 265-290 Front Matter....Pages 291-291 Endoluminal Diagnosis of Early Gastric Cancer and Its Precursors: Bridging the Gap Between Endoscopy and Pathology....Pages 293-316 Endoscopic Submucosal Dissection for Early Gastric Cancer: Getting It Right!....Pages 317-330 The Japanese Viewpoint on the Histopathology of Early Gastric Cancer....Pages 331-346 Syndromic Gastric Polyps: At the Crossroads of Genetic and Environmental Cancer Predisposition....Pages 347-369 Histopathological, Molecular, and Genetic Profile of Hereditary Diffuse Gastric Cancer: Current Knowledge and Challenges for the Future....Pages 371-391 Front Matter....Pages 393-408 Genomics Study of Gastric Cancer and Its Molecular Subtypes....Pages 409-418 Recapitulating Human Gastric Cancer Pathogenesis: Experimental Models of Gastric Cancer....Pages 291-291 Erratum to: Histopathological, Molecular, and Genetic Profile of Hereditary Diffuse Gastric Cancer: Current Knowledge and Challenges for the Future....Pages 419-439 Back Matter....Pages 441-478 ....Pages E1-E1 "This book is a comprehensive understanding of the evolution of pre-malignant disease, emphasizing common themes in the field, including stem cell biology and histologic modes of cancer progression between the distal esophagus and stomach. Its sixteen chapters discuss metaplastic tissue change in the upper GI, clonalexpansion of early neoplasia, stem cell dynamics in experimental models, pathology of early esophageal squamous cell carcinoma, therapeutic modalities for esophageal squamous cell carcinoma, pathology of Barrett esophagus, screening, early detection and novel diagnostic tools for Barrett's esophagus, clonal evolution of Barrett esophagus, endoscopic therapeutic modalities of early esophageal cancer, pathology of early gastric cancer, and experimental models for gastric cancer. Stem Cells, Pre-neoplasia and Early Cancer of the Upper Gastrointestinal Tract is an integrative text on both the current state of translational research on every cancer development of the upper gastrointestinal tract as well as on novel clinical diagnostic and therapeutic modalities. It highlights a rapidly growing field within cancer research and is essential reading for oncologists, biochemists and advanced graduate students alike. Springer Advances in Experimental Medicine and Biology series presents multidisciplinary and dynamic findings in the broad fields of experimental medicine and biology. The wide variety in topics it presents offers readers multiple perspectives on a variety of disciplines including neuroscience, microbiology, immunology, biochemistry, biomedical engineering and cancer research. ". Font no determinada