Stem Cells in Modeling Human Genetic Diseases (Stem Cell Biology and Regenerative Medicine)

While most stem cell books focus on basic aspects and/or cell therapy, this book emphasizes the relevance of stem cells obtained from patients, the so-called “patients in a petri dish” as tools to investigate human genetic diseases for which there are no available effective treatment. Chapters embrace several examples of the use of iPS cell technology, a recent Nobel Prize-winning scientific breakthrough, to obtain patient-specific pluripotent cells from which many types of specialized cells involved in a particular disease can be generated, including psychiatric and neurodegenerative disorders, muscular dystrophies, laminopathies, among others. The text is a current and timely resource for postgraduate students, scientists and clinicians, interested in applications of this rapidly developing field of research in disease modeling, drug development, and emerging issues that it brings to regenerative medicine. Using Stem Cells To Investigate Currently Untreatable Human Genetic Diseases Is The Focus Of This Book. Several Applications Of The Nobel-prize Winning, Revolutionary Ips Cell Technology Are Explored In Detail, Including In Schizophrenia, Autism, Huntington’s Disease, Alzheimer’s Disease, Spinocerebellar Ataxia, Medulloblastoma Heterogeneity, Progeria, Age-related Macular Degeneration, And Muscular Dystrophy . The Book Is Divided Into Seven Sections, Each Composed Of Authoritative And Detailed Chapters. The First Section Provides A Theoretical And Practical Overview Of Stem Cells In Disease Modeling. The Following Sections Divide Stem Cell Applications Into Various Classes Of Pathology- psychiatric Disorders, Neurodegenerative Disease, Neurogenesis-associated Disorders, And Laminopathies. Following These Sections, The Book Discusses The Future Perspectives- And Challenges- Of Ips Technology. Broad In Scope And In Audience, Stem Cells In Modeling Human Genetic Diseases for Postgraduate Students, Scientists, And Clinicians Interested In Applications Of The Rapidly Developing Field Of Stem Cell Research In Disease Modeling And Drug Development And Its Dynamic Role Within Regenerative Medicine. Modeling Fragile X Syndrome In Human Pluripotent Cells -- Induced Pluripotent Stem Cells In Familial Dilated Cardiomyopathy.- induced Pluripotent Stem Cells And Amyotrophic Lateral Sclerosis -- Ips Cells And Spinocerebellar Ataxia -- Induced Pluripotent Stem Cells And Vascular Disease -- Ips Cells And Cardiomyopathies -- Cancer Stem Cells And Chemoresistance -- Stem Cells In Autism Spectrum Disorders. Edited By Mayana Zatz, Oswaldo Keith Okamoto. Front Matter....Pages i-xii Modeling Fragile X Syndrome in Human Pluripotent Cells....Pages 1-10 Induced Pluripotent Stem Cells in Familial Dilated Cardiomyopathy....Pages 11-28 Induced Pluripotent Stem Cells and Amyotrophic Lateral Sclerosis....Pages 29-44 iPS Cells and Spinocerebellar Ataxia....Pages 45-61 Induced Pluripotent Stem Cells and Vascular Disease....Pages 63-81 iPS Cells and Cardiomyopathies....Pages 83-110 Cancer Stem Cells and Chemoresistance....Pages 111-119 Stem Cells to Understand the Pathophysiology of Autism Spectrum Disorders....Pages 121-142 Back Matter....Pages 143-147