Stem Cells: Basics and Clinical Translation (Translational Medicine Research Book 1)

This book provides a comprehensive review of the properties of various stem cell types, the mechanisms of their behaviors and their potential clinical application. Stem cells have a great capacity of self-renewal and differentiation. They represent new paradigms for disease treatment in the field of regenerative medicine since the day they were discovered. As stem cell research is complicated and making progress rapidly, it is important to have expertise in this field to share their views and perspectives. This book provides a wonderful platform for those who are interested in stem cells to learn from and communicate with experts. Particularly, it highlights the roles of stem cell based therapy for a variety of diseases. Furthermore, this book gives a detailed introduction to the great works related to stem cells in China. The readers could gain a profound knowledge of the state-of-art research done by scientists in the field of stem cells. Overall, this book will be a valuable reference resource for both experienced investigators pursuing stem cell research as well as those are just entering into this field. Dr. Robert Chunhua Zhao, a Cheung Kong Professor of Stem Cell Biology, is Professor of Cell Biology at the Institute of Basic Medical Sciences & School of Basic Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College (PUMC), Beijing, China. He is Director of the Center for Tissue Engineering, PUMC and Chief Scientist of the National Basic Research Program of China (ℓ́ℓ973 Programℓ́ℓ). He also serves as Regional Editor of Stem Cells and Development Front Matter....Pages i-xiii Front Matter....Pages 1-1 Primordial Germ Cells and Germ Line Stem Cells....Pages 3-28 Human Amniotic Fluid-Derived and Amniotic Membrane-Derived Stem Cells....Pages 29-66 Mesenchymal Stem Cells and Their Immunomodulatory Properties....Pages 67-83 Induced Pluripotent Stem Cell, a Rising Star in Regenerative Medicine....Pages 85-109 Stem Cells and Hematopoietic Cell Engineering....Pages 111-144 Signaling Pathways Regulating Stem Cells....Pages 145-177 The Concept of Mesenchymal Stem Cell System: Bring More Insights into Functional Research of MSCs....Pages 179-187 Human Neural Development and Human Embryonic Stem Cell Neural Differentiation....Pages 189-199 Molecular Imaging: The Key to Advancing Stem Cell Therapy....Pages 201-218 Stem Cell and Peripheral Nerve Regeneration....Pages 219-246 Biomaterial-Assisted Stem Cell Engineering for Tissue Construction and Regeneration....Pages 247-273 Front Matter....Pages 275-275 Stem Cells in the Treatment of Myocardial Infarction and Cardiomyopathy....Pages 277-316 Mesenchymal Stem Cell Therapy for Bladder Dysfunction....Pages 317-335 Mesenchymal Stem Cells in Cancer Therapy....Pages 337-360 Stem Cell Therapy for GVHD....Pages 361-389 Clinical Application and Molecular Mechanism of Multipotent Stem Cell Therapy for Liver Disease....Pages 391-414 Stem Cell Therapy for Cartilage Defects....Pages 415-434 Stem Cell Transplantation for Crohn’s Disease....Pages 435-454 Stem Cell Therapy for Optic Nerve Regeneration....Pages 455-470 Stem Cells and Spinal Cord Regeneration....Pages 471-498 Front Matter....Pages 275-275 Cell Transplantation Therapy for Diabetes Mellitus: From Embryonic Stem Cells to Transdifferentiation of Adult Cells....Pages 499-510 This book provides a comprehensive review of the properties of various stem cell types, the mechanisms of their behaviors and their potential clinical application. Stem cells have a great capacity of self-renewal and differentiation. They represent new paradigms for disease treatment in the field of regenerative medicine since the day they were discovered. As stem cell research is complicated and making progress rapidly, it is important to have expertise in this field to share their views and perspectives. This book provides a wonderful platform for those who are interested in stem cells to learn from and communicate with experts. Particularly, it highlights the roles of stem cell based therapy for a variety of diseases. Furthermore, this book gives a detailed introduction to the great works related to stem cells in China. The readers could gain a profound knowledge of the state-of-art research done by scientists in the field of stem cells. Overall, this book will be a valuable reference resource for both experienced investigators pursuing stem cell research as well as those are just entering into this field. Dr. Robert Chunhua Zhao, a Cheung Kong Professor of Stem Cell Biology, is Professor of Cell Biology at the Institute of Basic Medical Sciences & School of Basic Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College (PUMC), Beijing, China. He is Director of the Center for Tissue Engineering, PUMC and Chief Scientist of the National Basic Research Program of China (ĺl973 Programĺl). He also serves as Regional Editor of Stem Cells and Development This book provides a comprehensive review of the properties of various stem cell types, the mechanisms of their behaviors and their potential clinical application. Stem cells have a great capacity of self-renewal and differentiation. They represent new paradigms for disease treatment in the field of regenerative medicine since the day they were discovered. As stem cell research is complicated and making progress rapidly, it is important to have expertise in this field to share their views and perspectives. This book provides a wonderful platform for those who are interested in stem cells to learn from and communicate with experts. Particularly, it highlights the roles of stem cell based therapy for a variety of diseases. Furthermore, this book gives a detailed introduction to the great works related to stem cells in China. The readers could gain a profound knowledge of the state-of-art research done by scientists in the field of stem cells. Overall, this book will be a valuable reference resource for both experienced investigators pursuing stem cell research as well as those are just entering into this field. Dr. Robert Chunhua Zhao, a Cheung Kong Professor of Stem Cell Biology, is Professor of Cell Biology at the Institute of Basic Medical Sciences & School of Basic Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College (PUMC), Beijing, China. He is Director of the Center for Tissue Engineering, PUMC and Chief Scientist of the National Basic Research Program of China (z973 Programy). He also serves as Regional Editor of Stem Cells and Development