Stem Cells And Their Potential For Clinical Application (nato Science For Peace And Security Series A: Chemistry And Biology)

This publication was initiated on the occasion of the NATO-Advanced Study Institute (ASI) meeting “Stem Cells and their potential for clinical application” which took place from August 23 – 25, 2006 in Kyiv and from August 26 – 31, 2006 in Simeiz, Ukraine. The meeting was devoted to “hot topics” in Stem cell research such as Regulation of Haematopoietic and Non-haematopoietic Stem Cells, Clinical Application of Stem Cells, Preclinical Models and Gene Therapy. The editors are pleased that the original idea of a book could eventually be realised. This was made possible because of the willingness of many meeting participants to saddle themselves with the additional work of compiling their data and thoughts in form of an article for this edition. We are thus foremost grateful to all contributors for their valuable input. In accordance with the conference’s main topics, the book is divided into five chapters - “Haematopoietic stem cells and haematopoiesis”, “Biology of n- haematopoietic stem cells”, “Stem cells and malignancy”, “Cell processing; expansion and genetic modification” and “Clinical haematopoietic stem cell transplantation”. Front Matter....Pages i-xv Clonal Dominance after Reconstitution of the Haematopoietic System with Bone Marrow Cells Retroviral....Pages 1-15 Function of the Membrane-Bound Isoform Ligands of the Receptor Tyrosine Kinase Subclass III in Inducing Inducing Self-Renewal of Early Hematopoietic Progenitor Cells....Pages 17-44 Functional and Phenotypic Heterogeneity of the Human Hematopoietic Stem Cell (HSC) Compartment....Pages 45-53 Alterations of Frequency of Hematopoietic Precursors in Mice Subjected to Multiple Courses of Low-Dose G-CSF Injections....Pages 55-62 Regulation of Hematopoiesis by Growth Factors....Pages 63-75 Stem Cell Technologies in Gerontological Research....Pages 77-82 Osteopetrotic Models for Identifying Genes that Control Bone Resorption....Pages 83-104 Non-Hematopoietic Bone Marrow Cells for Regenerative Medicine....Pages 105-121 Epithelial Plasticity of Hepatocytes During Liver Tumor Progression....Pages 123-135 Blood Vessels as a Source of Progenitor Cells in Human Embryonic and Adult Life....Pages 137-147 Stem Cells and Leukaemia....Pages 149-161 Telomere and Stem Cell Biology in Chronic Myeloid Leukemia....Pages 163-169 Potential Immune Escape Mechanisms of Tumors: MHC Class I Molecules – Enemies or Friends....Pages 171-181 The RUNX1 Transcription Factor: A Gatekeeper in Acute Leukemia....Pages 183-199 Novel Methodological Approaches in Assessment and Enrichment of Stem Cell Population....Pages 201-210 Animal Hybrids and Stem Cells: Their Use in Biotechnology and Clinical Practice....Pages 211-222 Cryopreservation of Stem Cells....Pages 223-231 The M813 Retrovirus belongs to a Unique Interference Group and is Highly Fusogenic....Pages 233-244 Reconstructing an Anti-Tumor Immune Repertoire for Targeted AML Therapy....Pages 245-251 Experience of Kyiv Center of Stem Cell Transplantation....Pages 253-261 Anti Thymocyte Globuline Allows for Successful Transplantation from HLA Mismatched Unrelated Donors....Pages 263-274 This book contains contributions of leading international scientists who participated at the NATO-ASI conference???Stem cells and their potential for clinical application??? that was held in Kiev and Simeiz (Ukraine) from August 23??? 31, 2006. The articles cover a broad range of hot topics in stem cell and leukaemia research. Those include the potential of various stem cell types in regenerative and transplantation medicine, different mechanisms of malignant transformation leading to leukaemia development, as well as novel clinical strategies for malignant disease treatment such as adoptive The NATO-ASI conference Stem Cells and Their Potential for Clinical Application featured cutting-edge presentations ranging from laboratory research findings to the latest therapeutic applications. This book features contributions from many of the leading international scientists from North America and Western and Eastern Europe who participated in this conference. Articles cover a broad range of hot topics in stem cell and leukemia research.