Stem Cells and Cancer Stem Cells, Volume 12 : Therapeutic Applications in Disease and Injury

Volume 12 in this series explores the latest experimental and clinical uses of stem cells in the treatment of disease and of injuries and reviews methods for isolating multipotent endothelial-like cells from human adipose tissue and discusses clinical applications in cell therapy and regenerative medicine. The book is organized in five parts: Cancer Stem Cells, Pluripotent Stem Cells, Dendritic Stem Cells, Regenerative Medicine and General Applications. The first section includes chapters on histamine in the neural and cancer stem cell niches and emerging concepts of stem cell organization in the normal lung and in lung cancer. The section on Pluripotent Stem Cells includes discussion of the differentiation of dendritic cells from human induced pluripotent stem cell and the molecular mechanisms involved in reprogramming human somatic cells to generate induced pluripotent stem cells. Additional chapters cover the differentiation of induced pluripotent stem cells into functional cardiomyocytes, characteristics of satellite cells and multipotent adult stem cells in the skeletal muscle. The section on Dendritic Stem Cells explores the critical role of notch signaling in the differentiation and function of dendrite. Other chapters cover hypertensive emergencies in children after stem cell transplantation and overcoming the radio resistance of lung cancer stem cells. The section on Regenerative Medicine reports on experiments on improved renal revascularization in pigs using stem cells and phenotypic correction of murine Hemophilia A using cell-based therapy. The concluding section, General Applications, discusses such topics as methods in mathematical modeling for stem cells, as well as molecular and functional characterization of human adipocytes. Like its eleven predecessors in the series__,__ this volume stands out for its comprehensive approach, its roster of some 51 expert contributors representing a dozen different countries and its up-to-date review of leading-edge technology and methods. Front Matter....Pages i-xlii Front Matter....Pages 1-1 Histamine in the Neural and Cancer Stem Cell Niches....Pages 3-17 Emerging Concepts of Stem Cell Organization in the Normal Lung and in Lung Cancer....Pages 19-26 Front Matter....Pages 27-27 Differentiation of Dendritic Cells from Human Induced Pluripotent Stem Cells....Pages 29-37 Molecular Mechanisms Underlying Human Somatic Cell Reprogramming to Generate Induced Pluripotent Stem Cells....Pages 39-46 Induced Pluripotent Stem Cells Differentiate into Functional Cardiomyocytes....Pages 47-62 Characteristics of Satellite Cells and Multipotent Adult Stem Cells in the Skeletal Muscle....Pages 63-73 Front Matter....Pages 75-75 Notch Signaling in Differentiation and Function of Dendritic Cells....Pages 77-88 Suppression of Differentiation and Maturation of Dendritic Cells: Stem Cells from Different Sources Vary in Their Effect....Pages 89-94 Hypertensive Emergencies in Children After Stem Cell Transplantation: Care in Selecting Hypotensive Drugs....Pages 95-108 Decellularized Stem Cell Matrix: A Novel Approach for Autologous Chondrocyte Implantation-Based Cartilage Repair....Pages 109-115 Overcoming Radioresistance of Lung Cancer Stem Cells....Pages 117-127 Front Matter....Pages 129-129 Phenotypic Correction of Murine Hemophilia A Using Cell-Based Therapy....Pages 131-141 Improved Renal Revascularization Outcomes in Pigs Using Stem Cells....Pages 143-150 Generation of Autologous Multipotent Endothelial-Like Cells from Lipoaspirates of Human Adipose-Derived Stem Cells and Polymer Microarrays Technology: Potential Cardiovascular Regeneration....Pages 151-164 Adipose-Derived Stem Cells as a Novel Tool for Future Regenerative Medicine....Pages 165-174 Repairing the Stroke-Damaged Brain: From Neural Stem Cells to Tissue Engineering....Pages 175-185 Front Matter....Pages 187-187 Epithelial Plasticity Regulation by MicroRNAs....Pages 189-199 Methods in Mathematical Modeling for Stem Cells....Pages 201-217 Preoptic Regulatory Factor-2, a Rhogap Domain Protein that Modifies Cell Cycle Progression and Apoptosis in the CNS....Pages 219-230 Molecular and Functional Characterization of Human Adipocytes....Pages 231-240 Front Matter....Pages 187-187 Soluble CD40L in Stem Cell Products....Pages 241-245 Back Matter....Pages 247-256 Vast therapeutic applications of the following specific stem cells in disease and tissue injury are discussed: human embryonic stem cells, human mesenchymal stem cells, germ cell-derived pluripotent stem cells, induced pluripotent stem cells, human umbilical cord blood-derived stem cells, breast tumor stem cells,and hematopoietic stem cells.