Stem Cells and Cancer Stem Cells, Volume 11: Therapeutic Applications in Disease and injury (Stem Cells and Cancer Stem Cells, 11)

Volume 11 in this series discusses therapeutic applications of stem cells in disease and tissue injury. Coverage includes pluripotent stem cells, which can give rise to the endodermal, ectodermal, and mesodermal lineages; multipotent stem cells, which can generate all cells in a particular lineage and unipotent stem cells, which can give rise to only one cell type. This volume also examines cancer stem cells, tumor-initiating cells which possesses the capacity of self-renewal and can give rise to the heterogeneous lineages of cancer cells that comprise the tumor. Coverage extends to molecular mechanisms underlying the derivation and expansion of human embryonic stem cells, the role of specific proteins in the maintenance and inhibition of extraembryonic differentiation of these cells and the role of signaling responsible for the self-renewal of mouse embryonic stem cells. Nine chapters discuss the clinical importance of cancer stem cells, encompassing glioma, leukemia, ovarian cancer, pediatric sarcomas and head and neck squamous cell carcinoma. The role of cancer stem cells is also elucidated in epithelial-to-mesenchymal transition in spreading head and neck squamous cell carcinoma. The book goes on to survey therapeutic application of stem cells of hematopoietic and non-hematopoietic origin for regeneration of bones, including in osteoporotic bone disease; to illuminate the application of hematopoietic stem cells in bone regeneration and to discuss their use as a biomarker to facilitate determination of a treatment. The contributors review cells as biomarkers for pediatric solid tumors, and weigh the advantages and limitations of hematopoietic stem cell transplantation. Also included are details of neural stem cell engraftment in the injured spinal cord; the regenerative potential of neural stem/progenitor cells of newborns and cancer gene therapy potential using neural stem cells. Like the preceding volumes in the series, this book is distinguished for its comprehensive approach, its distinguished roster of 58 contributors representing 10 different countries and its thorough review of leading-edge technology and methods. Front Matter....Pages i-xxxviii Front Matter....Pages 1-1 Maintenance of Human Embryonic Stem Cell Identity and Inhibition of Extraembryonic Differentiation: Role of CNOT1, CNOT2 and CNOT3....Pages 3-14 Investigating the Role of the Embryonic Stem Cell Self-Renewal Gene NANOG in Neoplastic Processes....Pages 15-27 Derivation and Expansion of Human Embryonic Stem Cells Under Xeno-Free, Defined Conditions....Pages 29-39 Self-Renewal of Naïve State Mouse Embryonic Stem Cells: Role of LacdiNAc in LIF/STAT3 Signaling....Pages 41-49 Cancer Gene Therapy Potential of Neural Stem Cells Derived from Human Embryonic Stem Cells and Induced Pluripotent Stem Cells....Pages 51-63 Front Matter....Pages 65-65 The Role of Cancer Stem(–Like) Cells and Epithelial-to-Mesenchymal Transition in Spreading Head and Neck Squamous Cell Carcinoma....Pages 67-74 Glioma Propagating Cells Show Enhanced Chemoresistance and Radioresistance (an Update)....Pages 75-91 Chemical Genomic Approaches to Eradicate Leukemia Stem Cells....Pages 93-101 Isolation of Cancer Stem Cells Showing Drug Resistance in the Human Epithelia Ovarian Cancer....Pages 103-109 Cancer Stem Cells in Pediatric Sarcomas....Pages 111-126 Cancer Stem Cells Derived from Mouse Induced Pluripotent Stem Cells....Pages 127-133 Stemness Regulation of Somatic Cancer Cells....Pages 135-147 Induced Differentiation of Brain Tumour Stem Cells....Pages 149-158 Role of Microenvironment in Regulating Stem Cell and Tumor Initiating Cancer Cell Behavior and Its Potential Therapeutic Implications....Pages 159-169 Identification of Ovarian Cancer Stem Cells: Molecular Pathways....Pages 171-185 Front Matter....Pages 187-187 Hematopoietic Stem Cells and Bone Regeneration....Pages 189-200 Children with Solid Tumors: Identification of Hematopoietic and Endothelial Progenitor Cells as Biomarkers....Pages 201-207 Pediatric Neuroblastoma: Combined Treatment with Monoclonal Antibody and Cytokines Preceded by Hematopoietic Stem Cell Transplantation....Pages 209-220 Autologous and Allogeneic Hematopoieitic Cell Transplantation: Risk of Second Malignancies....Pages 221-230 Front Matter....Pages 231-231 Treatment of Injured Spinal Cord: Engraftment of Neural Stem Cells....Pages 233-240 Front Matter....Pages 231-231 Spinal Cord Injury Engineering Using Neural Stem Cells....Pages 241-252 Endogenous Regenerative Potential of Neural Stem/Progenitor Cells of the Newborn Brain (An Overview)....Pages 253-263 Back Matter....Pages 265-280 Vast therapeutic applications of the following specific stem cells in disease and tissue injury are discussed: human embryonic stem cells, human mesenchymal stem cells, germ cell-derived pluripotent stem cells, induced pluripotent stem cells, human umbilical cord blood-derived stem cells, breast tumor stem cells,and hematopoietic stem cells.