Stem Cells and Cancer Stem Cells, Volume 10: Therapeutic Applications in Disease and Injury (Stem Cells and Cancer Stem Cells (10))

Presenting contributions by 66 experts representing 13 countries, Volume 10 of the series Stem Cells and Cancer Stem Cells synthesizes current understanding of the causes, diagnosis, and therapy of major human diseases and debilitating tissue and organ injuries, using cell-based treatment. This volume presents contemporary research into generation, preservation, and uses of stem cells in fighting disease and tissue/organ injuries. The contents of the volume are organized into five sections. Mesenchymal Stem Cells section includes chapters on the use of stem cells in bone regeneration, studies and trials of stem cells in autoimmune diseases, and differences between adipose tissue-derived mesenchymal stem cells and bone marrow-derived mesenchymal stem cells as regulators of immune response. Induced Pluripotent Stem Cells section offers chapters on drug discovery using human IPSC-based disease models, and on generation of antigen-specific lymphocytes from IPSCs. Neural Cells and Neural Stem Cells section discusses use of bacterial artificial chromosomes in the genetic identification of stem cell-derived neural cell types, and use of moderate low temperature to preserve the stemness of neural stem cells. The section, Role of Stem Cells in Disease, discusses stem cell support in high-dose chemotherapy of Non-Hodgkin’s Lymphomas; potential targets for drug resistant leukemic stem cells, bone marrow stem cell therapies for diabetes mellitus. This section also discusses the use of stem cells in treating thyroid, breast and bone cancers, hempophilia and Parkinson’s Disease. The section, Stem Cell Transplantation, includes chapters on reducing fungal infection in allogenic stem cell transplantation patients, use of Bulsufan/Fludarabine for conditioning in haematopoietic stem cell transplantation, and interleukin-7 receptor alpha polymorphisms in allogeneic stem cell transplantation. The editor, M.A. Hayat, is a Distinguished Professor in the Department of Biological, Sciences at Kean University, Union, New Jersey, USA. Front Matter....Pages i-xlii Front Matter....Pages 1-1 Mesenchymal Stem Cells in Bone Regeneration....Pages 3-11 Experimental (Preclinical) Studies and Clinical Trials of Adipose Tissue-Derived Mesenchymal Stem Cells for Autoimmune Diseases....Pages 13-22 Validity of Markers for Epithelial Cells and Mesenchymal Cells....Pages 23-33 Mesenchymal Stem Cell Survival in Infarcted Myocardium: Adhesion and Anti-death Signals....Pages 35-43 Hepatogenic Differentiation: Comparison Between Adipose Tissue-Derived Stem Cells and Bone Marrow Mesenchymal Stem Cells....Pages 45-57 Fibrin for Encapsulation of Human Mesenchymal Stem Cells for Chondrogenic Differentiation....Pages 59-69 Differences Between Adipose Tissue-Derived Mesenchymal Stem Cells and Bone Marrow-Derived Mesenchymal Stem Cells as Regulators of the Immune Response....Pages 71-84 Transforming Growth Factor-Beta Induced Chrondrogenic Differentiation of Bone Marrow-Derived Mesenchymal Stem Cells: Role of Smad Signaling Pathways....Pages 85-91 Front Matter....Pages 93-93 Drug Discovery Using Human iPSC Based Disease Models and Functional Hepatic Cells....Pages 95-103 Generation of Antigen-Specific T Lymphocytes from Induced Pluripotent Stem Cells for Adoptive Immunotherapy....Pages 105-121 Front Matter....Pages 123-123 Genetic Identification of Human Embryonic Stem Cell-Derived Neural Cell Types Using Bacterial Artificial Chromosomes....Pages 125-136 Moderate Low Temperature Preserves the Stemness of Neural Stem Cells (Methods)....Pages 137-145 Front Matter....Pages 147-147 High-Dose Chemotherapy with Autologous Stem Cell Support in the Treatment of Transformed B-Cell Non-Hodgkin’s Lymphomas....Pages 149-162 The Wnt/β-Catenin Pathway as a Potential Target for Drug Resistant Leukemic Stem Cells....Pages 163-172 Bone Marrow Stem Cell Therapies for Diabetes Mellitus and Its Complications....Pages 173-179 Thyroid Cancer Stem Cells – Strategies for Therapeutic Targeting....Pages 181-187 Role of Cancer Stem Cell in Mammary Carcinogenesis and Its Clinical Implication....Pages 189-197 Critical Analysis of Parkinson’s Disease Models and Cell-Based Therapy....Pages 199-210 Presence of an Early Lineage Stem Cell Phenotype in Meningioma-Initiating Cells....Pages 211-218 Isolation and Characterization of Cancer Stem Cells from Dog Glioblastoma....Pages 219-228 Front Matter....Pages 147-147 Role of Stem Cell Niche in the Development of Bone Metastases (An Update)....Pages 229-238 Treatment of Hemophilia A Using B Cell-Directed Protein Delivery....Pages 239-249 Front Matter....Pages 251-251 Reduction in the Risk Invasive Fungal Infection Relapse in Patients Undergoing Allogenic Stem Cell Transplantation Using Caspofunginas Secondary Prophylaxis....Pages 253-262 Hematopoietic Stem Cell Transplantation in Elderly Patients with Myelodisplastic Syndrome and Acute Myelogenous Leukemia: Use of Busulfan/Fludarabine for Conditioning....Pages 263-269 Co-transplantation of Islets with Mesenychymal Stem Cells Improves Islet Revascularization and Reversal of Hyperglycemia....Pages 271-282 Significance of Interleukin-7 Receptor Alpha Polymorphisms in Allogeneic Stem Cell Transplantation....Pages 283-290 Back Matter....Pages 291-298 "Volume 10 of the series Stem Cells and Cancer Stem Cells synthesizes current understanding of the causes, diagnosis, and therapy of major human diseases and debilitating tissue and organ injuries, using cell-based treatment. This volume presents contemporary research into generation, preservation, and uses of stem cells in fighting disease and tissue/organ injuries. The contents of the volume are organized into five sections. Mesenchymal Stem Cells section includes chapters on the use of stem cells in bone regeneration, studies and trials of stem cells in autoimmune diseases, and differences between adipose tissue-derived mesenchymal stem cells and bone marrow-derived mesenchymal stem cells as regulators of immune response. Induced Pluripotent Stem Cells section offers chapters on drug discovery using human IPSC-based disease models, and on generation of antigen-specific lymphocytes from IPSCs. Neural Cells and Neural Stem Cells section discusses use of bacterial artificial chromosomes in the genetic identification of stem cell-derived neural cell types, and use of moderate low temperature to preserve the stemness of neural stem cells. The section, Role of Stem Cells in Disease, discusses stem cell support in high-dose chemotherapy of Non-Hodgkin's Lymphomas; potential targets for drug resistant leukemic stem cells, bone marrow stem cell therapies for diabetes mellitus. This section also discusses the use of stem cells in treating thyroid, breast and bone cancers, hempophilia and Parkinson's Disease. The section, Stem Cell Transplantation, includes chapters on reducing fungal infection in allogenic stem cell transplantation patients, use of Bulsufan/Fludarabine for conditioning in haematopoietic stem cell transplantation, and interleukin-7 receptor alpha polymorphisms in allogeneic stem cell transplantation"--Publisher's description Vast therapeutic applications of the following specific stem cells in disease and tissue injury are discussed: human embryonic stem cells, human mesenchymal stem cells, germ cell-derived pluripotent stem cells, induced pluripotent stem cells, human umbilical cord blood-derived stem cells, breast tumor stem cells,and hematopoietic stem cells.