Stem Cells and Cancer Stem Cells, Volume 1 : Stem Cells and Cancer Stem Cells, Therapeutic Applications in Disease and Injury: Volume 1

Difference between tissue specific stem cells and embryonic stem cells is explained. The advantages of the latter are included. The application of human pluripotent stem cells, mesenchymal stem cells, and hematopoietic stem cells in cancer therapy and tissue/organ regeneration is detailed. Role of neural cancer stem cells in brain tumors, including their role in brain tumor therapy and the role of CD133 stem cell antigen in glioma patients, is emphasized. Therapeutic role of bone marrow-derived stem cells in myocardial infarction and the role of mesenchymal stem cells in orthopedics are explained. Transplantation of umbilical cord hematopoietic stem cells and allogeneic hematopoietic stem cell transplantation followed by graft-versus-host disease are presented. Role of cancer stem cells specifically in glioblastoma and medulloblastoma is included. It is also emphasized that CD133 is an appropriate stem cell marker for gliomas. Targeting of cancer cells is also explained. Front Matter....Pages i-xv Front Matter....Pages 1-1 Pluripotent Human Stem Cells: An Overview....Pages 3-12 Complexity of Tumor Angiogenesis and Stem Cells....Pages 13-20 Stem Cells Like Astrocytes: Various Roles....Pages 21-26 Front Matter....Pages 27-27 Neural Crest Cell-Derived Tumors: An Overview....Pages 29-40 Therapeutic Neural Stem Cells for Brain Tumor Therapy....Pages 41-47 Brain Tumors: Role of Neural Cancer Stem Cells....Pages 49-57 Front Matter....Pages 59-59 Targeting Cancer Stem Cells with Phytochemicals: Inhibition of the Rat C6 Glioma Side Population by Curcumin....Pages 61-68 Glioma Patients: Role of CD133 Stem Cell Antigen....Pages 69-76 Cancer Stem Cells in Brain Gliomas....Pages 77-82 Primary Glioma Spheroids: Advantage of Serum-Free Medium....Pages 83-91 Tumorigenesis of Glioma-Initiating Cells: Role of Sox11....Pages 93-98 Glioma-Initiating Cells: Interferon Treatment....Pages 99-106 Is CD133 the Appropriate Stem Cell Marker for Glioma?....Pages 107-112 Cancer Stem Cells in Glioblastoma....Pages 113-120 Glioblastoma-Derived Cancer Stem Cells: Treatment with Oncolytic Viruses....Pages 121-128 Cancer Stem Cells in Medulloblastoma....Pages 129-139 Front Matter....Pages 141-141 Transplantation of Embryonic Stem Cells Results in Reduced Brain Lesions....Pages 143-147 Allogenic Hematopoietic Stem Cell Transplantation Followed by Graft-Versus-Host Disease: Role of Adenosine A 2A Receptor....Pages 149-155 Umblical Cord Blood and Alpha-3 Fucosyl Transferase-Treated Haematopoietic Stem Cells for Transplantation....Pages 157-162 Bone Marrow-Derived Stem Cell Therapy for Myocardial Infarction....Pages 163-171 Front Matter....Pages 141-141 The Use of Mesenchymal Stem Cells in Orthopedics....Pages 173-179 Back Matter....Pages 181-198 Vast therapeutic applications of the following specific stem cells in disease and tissue injury are discussed: human embryonic stem cells, human mesenchymal stem cells, germ cell-derived pluripotent stem cells, induced pluripotent stem cells, human umbilical cord blood-derived stem cells, breast tumor stem cells,and hematopoietic stem cells. This book discusses therapeutic application of specific stem cells: embryonic stem cells, induced pluripotent stem cells, human hair follical stem cells, bone marrow-derived human mesenchymal stem cells, cancer and breast cancer stem cells, among others.