Stem Cell Transplantation for Hemotologic Malignancies (Contemporary Hematology) (Contemporary Hematology)

A comprehensive survey of the current state-of-the-art in hematopoietic stem cell transplantation for malignant disease. The authors focus on the indications and results of transplantation for acute leukemia, chronic myelogenous leukemia, lymphoma, multiple myeloma, and breast cancer. Special attention is given to transplant-related complications, including the pathophysiology and clinical consequences of acute and chronic GVHD, delayed immune reconstitution leading to infectious complications, and organ damage to the lung and liver. Additional chapters address the sources of stem cells and the effects of graft manipulation used to eliminate residual contaminating tumor cells in autologous transplantation, or to reduce the number of T lymphocytes causing GVHD in allogenic transplantation. In This Volume, Leading Investigators And Physicians/clinicians Complrehensively Survey The Current State-of-the-art In Hematopoietic Stem Cell Transplantation For Malignant Disease. The Authors Focus On The Indications And Results Of Transplantation For Acute Leukemia, Chronic Myelogenous Leukemia, Lymphoma, Multiple Myeloma, And Breast Cancer, Providing Insight Into The Relative Merits Of Transplant And Nontransplant Approaches To These Disorders. Allogeneic And Autologous Stem Cell Transplantation For Acute Leukemia And Myelodysplasia In The Adult / Sandra Cohen And Stephen J. Forman -- Hematopoietic Stem Cell Transplantation For Chronic Myelogenous Leukemia / Humberto Caldera And Sergio Giralt -- Stem Cell Transplantation For Hodgkin's And Non-hodgkin's Lymphomas / Thomas J. Kenney And John W. Sweetenham -- Autologous And Allogeneic Transplantation For Multiple Myeloma / Faith E. Davies And Kenneth C. Anderson -- Hematopoietic Progenitor Cell Transplantation For Breast Cancer / Yago Nieto And Elizabeth J. Shpall -- Pathophysiology Of Acute Graft-vs-host Disease / Takanori Teshima And James L.m. Ferrara -- Acute Graft-vs-host Disease / Uwe Platzbecker And H. Joachim Deeg -- Chronic Graft-vs-host Disease After Transplantation / Georgia B. Vogelsang And Colleen H. Mcdonough -- Immune Reconstitution After Allogeneic Transplantation / Carolyn A. Keever-taylor -- Infection In The Hematopoietic Stem Cell Transplant Recipient / Lindsey Baden And Robert H. Rubin -- Ebv Lymphoproliferative Disease After Transplantation / Stephen Gottschalk, Cliona M. Rooney, And Helen E. Heslop -- Pathophysiology Of Lung Injury After Hematopoietic Stem Cell Transplantation / Kenneth R. Cooke -- Hepatic Veno-occlusive Disease / Paul G. Richardson -- Quality-of-life Issues Posttransplantation / Stephanie J. Lee. Stem Cell Sources: Peripheral Blood Stem Cells And Bone Marrow For Allogeneic Transplantation / Corey Cutler And Joseph H. Antin -- Allogeneic Unrelated Donor Blood And Marrow Transplantation / Daniel Weisdorf -- Haploidentical Stem Cell Transplantation / P. Jean Henslee-downey -- Umbilical Cord Hematopoietic Stem Cell Transplantation / Timothy F. Goggins And Nelson J. Chao -- Tumor Contamination Of Stem Cell Products: The Role Of Purging / John G. Gribben -- T-cell Depletion To Prevent Graft-vs-host Disease / Vincent Ho And Robert J. Soiffer -- Donor Lymphocyte Infusions: Clinical Applications And The Graft-vs-leukemia Effect / Edwin P. Alyea Iii -- Nonmyeloablative Transplantation / Lyle C. Feinstein And Brenda M. Sandmaier. Edited By Robert J. Soiffer. Includes Bibliographical References And Index. Allogeneic and autologous stem cell transplantation for acute leukemia and myelodysplasia in the adult / Sandra Cohen and Stephen J. Forman Hematopoietic stem cell transplantation for chronic myelogenous leukemia / Humberto Caldera and Sergio Giralt Stem cell transplantation for Hodgkin's and non-Hodgkin's lymphomas / Thomas J. Kenney and John W. Sweetenham Autologous and allogeneic transplantation for multiple myeloma / Faith E. Davies and Kenneth C. Anderson Hematopoietic progenitor cell transplantation for breast cancer / Yago Nieto and Elizabeth J. Shpall Pathophysiology of acute graft-vs-host disease / Takanori Teshima and James L. M. Ferrara Acute graft-vs-host disease / Uwe Platzbecker and H. Joachim Deeg Chronic graft-vs-host disease after transplantation / Georgia B. Vogelsang and Colleen H. Mcdonough Immune reconstitution after allogeneic transplantation / Carolyn A. Keever-Taylor Infection in the hematopoietic stem cell transplant recipient / Lindsey Baden and Robert H. Rubin EBV lymphoproliferative disease after transplantation / Stephen Gottschalk, Cliona M. Rooney, and Helen E. Heslop Pathophysiology of lung injury after hematopoietic stem cell transplantation / Kenneth R. Cooke Hepatic veno-occlusive disease / Paul G. Richardson Quality-of-life issues posttransplantation / Stephanie J. Lee. Stem cell sources: peripheral blood stem cells and bone marrow for allogeneic transplantation / Corey Cutler and Joseph H. Antin Allogeneic unrelated donor blood and marrow transplantation / Daniel Weisdorf Haploidentical stem cell transplantation / P. Jean Henslee-Downey Umbilical cord hematopoietic stem cell transplantation / Timothy F. Goggins and Nelson J. Chao Tumor contamination of stem cell products: the role of purging / John G. Gribben T-cell depletion to prevent graft-vs-host disease / Vincent Ho and Robert J. Soiffer Donor lymphocyte infusions: clinical applications and the graft-vs-leukemia effect / Edwin P. Alyea III Nonmyeloablative transplantation / Lyle C. Feinstein and Brenda M. Sandmaier. Acute lymphoblastic leukemia (ALL) is characterized by clonal proliferation, accumulation, and tissue infiltration of immature lymphoid cells of the bone marrow.