Statistical mechanics and stability of macromolecules : application to bond disruption, base pair separation, melting, and drug dissociation of the DNA double helix

This book develops a statistical mechanical analysis of the stability of biological macromolecules. The author's approach is valid both for the long time-scale needed for DNA bond disruption, and also for highly cooperative transitions needed to explain helix melting. Prohofsky develops a new theoretical approach for executing macromolecule calculations. In particular the author devises a method for describing chemical bond disruption in these large systems, which is then used to determine when the helix melts and how drugs can dissociate from the helix. The author finds melting temperatures to be in excellent agreement with experimental observations.

this Book Develops A Statistical, Mechanical Analysis Of The Stability Of Macromolecules When Melting.

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develops A Statistical Mechanical Analysis Of The Stability Of Biological Macromolecules That Is Valid Both For The Long Time Scale Needed For Dna Bond Disruption And For The Highly Cooperative Transitions Needed To Explain Helix Melting. Devises A Method For Describing Chemical Bond Disruption In Such Systems, And Uses That To Determine When The Helix Melts And How Drugs Can Dissociate From The Helix. Then Shows How To Account For Environmental Variables And How To Perform Calculations On Specific Structures Embedded In A Large Helix And On The Dynamic Effects Of Enzyme Attachments. For Researchers And Graduate Students In Biological Physics, Theoretical Chemistry, And Molecular Biology. Annotation C. Book News, Inc., Portland, Or (booknews.com)

This book develops a statistical mechanical analysis of the stability of biological macromolecules. The author's approach is valid both for the long time-scale needed for DNA bond disruption, and also for highly co-operative transitions needed to explain helix melting. A new theoretical approach for executing macromolecule calculations is developed. In particular, the author devises a method for describing chemical bond disruption in these large systems, which are then used to determine when the helix melts and how drugs can dissociate from the helix. Melting temperatures are found to be in excellent agreement with experimental observations. The book will be of interest to biomolecular dynamics researchers, especially to graduate students in biological physics, theoretical chemistry and molecular biology Develops a statistical mechanical analysis of the stability of biological macromolecules. Moreover, it develops a new theoretical approach for executing macromolecule calculations. Of interest to biomolecular dynamics researchers in biological physics and theoretical chemistry. Biological macromolecules carry out functions that require them to have very complex physical and chemical dynamics.