STAT Inhibitors in Cancer (Cancer Drug Discovery and Development)

"This volume, which includes contributions from leading scientists and clinicians in the field, provides definitive, state-of-the-art information on STAT inhibitors in a biological and clinical context. It gives an overview of the biology of the STAT family of transcription factors and their role in cancer etiology. Additionally, it describes the raft of therapeutic approaches being used to inhibit STATs in the context of various cancers, covering the full spectrum of therapeutic approaches to inhibiting STATs, and presenting emerging data from clinical trials. ". Font no determinada Front Matter....Pages i-vii STATs in Health and Disease....Pages 1-32 STAT Proteins in Cancer....Pages 33-47 Translating STAT Inhibitors from the Lab to the Clinic....Pages 49-68 Historical Development of STAT3 Inhibitors and Early Results in Clinical Trials....Pages 69-94 STAT3 Inhibitors in Cancer: A Comprehensive Update....Pages 95-161 Targeting Upstream Janus Kinases....Pages 163-175 Inhibitors of Upstream Inducers of STAT Activation....Pages 177-190 Back Matter....Pages 191-195