Springer eBooks -- Fundamentals of Chromatin

While there has been an increasing number of books on various aspects of epigenetics, there has been a gap over the years in books that provide a comprehensive understanding of the fundamentals of chromatin. ​Chromatin is the combination of DNA and proteins that make up the genetic material of chromosomes. Its primary function is to package DNA to fit into the cell, to strengthen the DNA to prevent damage, to allow mitosis and meiosis, and to control the expression of genes and DNA replication. The audience for this book is mainly newly established scientists ​and graduate students. Rather than going into the more specific areas of recent research on chromatin the chapters in this book give a strong, updated groundwork about the topic. Some the fundamentals that this book will cover include the structure of chromatin and biochemistry and the enzyme complexes that manage it. Front Matter....Pages i-xiii Histone, Nucleosome, and Chromatin Structure....Pages 1-28 Histone Chaperones in the Assembly and Disassembly of Chromatin....Pages 29-67 Chromatin Remodeling Complexes....Pages 69-146 Regulating Chromatin by Histone Acetylation....Pages 147-212 Histone Methylation in Chromatin Signaling....Pages 213-256 Histone Ubiquitylation Control of Gene Expression....Pages 257-307 Regulation of Chromatin Structure and Function by PARP-1 and ADP-Ribosylation....Pages 309-339 Histone Phosphorylation and Chromatin Dynamics....Pages 341-354 Reading Histone Modifications....Pages 355-373 Properties and Functions of Histone Variants....Pages 375-426 Transcription Through Chromatin....Pages 427-489 Chromatin Remodeling in DNA Repair and Replication....Pages 491-527 Heterochromatin: A Critical Part of the Genome....Pages 529-552 Emerging Areas of Chromatin Research....Pages 553-571 Back Matter....Pages 573-587 Chromatin is the combination of DNA and proteins that make up the genetic material of chromosomes. It is essential for packaging DNA, regulation of gene expression, DNA replication and repair. The audience for this book includes newly established scientists, graduate students and scientists seeking detailed overviews of various aspects of chromatin structure and function to gain entry into this field. The chapters in this book give a strong, updated groundwork about the fundamentals of chromatin which are essential to understand epigenetics. Some the fundamentals that this book covers include the structure and biochemistry of chromatin and the enzyme complexes that manage it This book focuses on fundamental properties of chromatin that include structure, composition, modifications and functions in nuclear processes such as transcription, and DNA replication and repair