Spinal Cord Trauma: Regeneration, Neural Repair and Functional Recovery (Progress in Brain Research)

This book covers, in a broad perspective, research on spinal cord injury, beginning with human spinal cord injury to experimental studies in animals, to molecular mechanisms of injury and regeneration. Every year 12,000 will suffer spinal cord injury leading to permanent disability. In the last five years enormous progress has been made in the understanding of spinal cord injury, and in ways to elicit repair in animal models of spinal cord injury. The scope includes animal models of spinal cord injury, strategies for neuroprotection and regeneration, and possible roles of axon guidance molecules in injury and regeneration. Topical reviews are presented as well as new data on timely issues in spinal cord injury research. Content: List of contributors Pages v-x Foreword by Christopher Reeve Page xi Preface Page xiii Lisa McKerracher, Guy Doucets, Serge Rossignol Chapter 1 Advances in imaging of spinal cord injury: implications for treatment and patient evaluation Original Research Article Pages 3-8 Robert M. Quencer Chapter 2 A review of the adaptability and recovery of locomotion after spinal cord injury Original Research Article Pages 9-25 H. Harbeau, J. Fung, A. Leroux, M. Ladouceur Chapter 3 Electrical stimulation for therapy and mobility after spinal cord injury Original Research Article Pages 27-34 Richard B. Stein, Su Ling Chong, Kelvin B. James, Aiko Kido, Gordon J. Bell, L.Aaron Tubman, Marc Bélanger Chapter 4 Cell death in models of spinal cord injury Original Research Article Pages 37-47 Michael S. Beattie, Gerlinda E. Hermann, Richard C. Rogers, Jacqueline C. Bresnahan Chapter 5 Gray matter repair in the cervical spinal cord Original Research Article Pages 49-70 Paul J. Reier, Francis J. Golder, Donald C. Bolser, Charles Hubscher, Richard Johnson, Gregory W. Schrimsher, Margaret J. Velardo Chapter 6 Spinal cord neural organization controlling the urinary bladder and striated sphincter Original Research Article Pages 71-82 Susan J. Shefchyk Chapter 7 Central mechanisms for autonomic dysreflexia after spinal cord injury Original Research Article Pages 83-95 Lynne C. Weaver, Daniel R. Marsh, Denis Gris, Susan O. Meakin, Gregory A. Dekaban Chapter 8 The spinal locomotor CPG: a target after spinal cord injury Original Research Article Pages 97-108 Sten Grillner Chapter 9 Activation and coordination of spinal motoneuron pools after spinal cord injury Original Research Article Pages 109-124 Arthur Prochazka, Vivian Mushahwar, Sergiy Yakovenko Chapter 10 Propriospinal neurons involved in the control of locomotion: potential targets for repair strategies? Original Research Article Pages 125-139 Larry M. Jordan, Brian J. Schmidt Chapter 11 Use of robotics in assessing the adaptive capacity of the rat lumbar spinal cord Original Research Article Pages 141-149 Ray D. de Leon, David J. Reinkensmeyer, Wojciech K. Timoszyk, Nicolas J. London, Roland R. Roy, V. Reggie Edgerton Chapter 12 The cat model of spinal injury Original Research Article Pages 151-168 S. Rossignol, C. Chau, N. Giroux, E. Brustein, L. Bouyer, J. Marcoux, C. Langlet, D. Barthelémy, J. Provencher, H. Leblond, H. Babeau, T.A. Reader Chapter 13 Neurotrauma/neurodegeneration and mitochondrial dysfunction Original Research Article Pages 171-176 Marina Frantseva, Jose Luis Perez Velazquez, Alexandre Tonkikh, Yana Adamchik, Peter L. Carlen Chapter 14 Secondary injury mechanisms of spinal cord trauma: a novel therapeutic approach for the management of secondary pathophysiology with the sodium channel blocker riluzole Original Research Article Pages 177-190 Gwen Schwartz, Michael G. Fehlings Chapter 15 Strategies for regeneration and repair in spinal cord traumatic injury Original Research Article Pages 191-212 Minerva Giménez y Ribotta, Manuel Gaviria, Véronique Menet, Alain Privat Chapter 16 Locomotor recovery in chronic spinal rat: long-term pharmacological treatment or transplantation of embryonic neurons? Original Research Article Pages 213-230 D. Orsal, J.-Y. Barthe, M. Antri, D. Feraboli-Lohnherr, A. Yakovleff, M.Giménez y Ribotta, A. Privat, J. Provencher, S. Rossignol Chapter 17 Spinal cord contusion models Original Research Article Pages 231-255 Wise Young Chapter 18 Transplants and neurotrophic factors increase regeneration and recovery of function after spinal cord injury Original Research Article Pages 257-273 Barbara S. Bregman, Jean-Valery Coumans, Hai Ning Dai, Penelope L. Kuhn, James Lynskey, Marietta McAtee, Faheem Sandhu Chapter 19 Bridging the transected or contused adult rat spinal cord with Schwann cell and olfactory ensheathing glia transplants Original Research Article Pages 275-282 Mary Bartlett Bunge Chapter 20 Potent possibilities: endogenous stem cells in the adult spinal cord Original Research Article Pages 283-297 Adam C. Lipson, Philip J. Homer Chapter 21 Repairing the damaged spinal cord: a summary of our early success with embryonic stem cell transplantation and remyelination Original Research Article Pages 299-309 John W. McDonald, Michael J. Howard Chapter 22 Chondroitin sulphate proteoglycans in the CNS injury response Original Research Article Pages 313-332 Daniel A. Morgenstern, Richard A. Asher, James W. Fawcett Chapter 23 The extracellular matrix in axon regeneration Original Research Article Pages 333-349 Barbara Grimpe, Jerry Silver Chapter 24 Increasing plasticity and functional recovery of the lesioned spinal cord Original Research Article Pages 351-359 Martin E. Schwab Chapter 25 Nogo and the Nogo-66 receptor Original Research Article Pages 361-369 Alyson E. Fournier, Tadzia GrandPré, Graham Gould, Xingxing Wang, Stephen M. Strittmatter Chapter 26 Inactivation of intracellular Rho to stimulate axon growth and regeneration Original Research Article Pages 371-380 Benjamin Ellezam, Catherine Dubreuil, Matthew Winton, Leanna Loy, Pauline Dergham, Inmaculada Belles-Navarro, Lisa McKerracher Chapter 27 A role for cAMP in regeneration during development and after injury Original Research Article Pages 381-387 Jin Qiu, Dongming Cai, Marie T. Filbin Chapter 28 Inosine stimulates axon growth in vitro and in the adult CNS Original Research Article Pages 389-399 Larry I. Benowitz, David E. Goldberg, Nina Irwin Chapter 29 T cell-based therapeutic vaccination for spinal cord injury Original Research Article Pages 401-406 Michal Schwartz, Ehud Hauben Chapter 30 Recruiting the immune response to promote long distance axon regeneration after spinal cord injury Original Research Article Pages 407-414 Samuel David Chapter 31 Spontaneous and neurotrophin-induced axonal plasticity after spinal cord injury Original Research Article Pages 415-423 Armin Blesch, Mark H. Tuszynski Chapter 32 Where the rubber meets the road: netrin expression and function in developing and adult nervous systems Original Research Article Pages 425-442 Colleen Manitt, Timothy E. Kennedy Chapter 33 Reinnervation of the pretectum in adult rats by regenerated retinal ganglion cell axons: anatomical and functional studies Original Research Article Pages 443-452 Manuel Vidal-Sanz, Marcelino Avilés-Trigueros, Simon J.O. Whiteley, Yves Sauvé, Raymond D. Lund Chapter 34 Seeking axon guidance molecules in the adult rat CNS Original Research Article Pages 453-465 Guy Doucet, Audrey Petit Subject index Pages 467-470