Sphingolipids And Metabolic Disease (advances In Experimental Medicine And Biology)

Current Thinking Holds That Obesity Derives Primarily From Overnutrition (though Compelling Arguments For Other Mechanisms, Like Endocrine Disruption By Environmental Pollutants, Also Gain Support From The Literature). In Animals, Overnutrition Is Initially Handled By Adipose Tissue Expansion; However, Exhaustion Of This Route Of Lipid Sequestering Results In Oversupply Of Lipid To Other Tissues Including Skeletal Muscle, Heart, Liver, And Others. Failure Of These Tissues To Clear Excess Lipids Through Either Metabolism Or Sequestration Into Putatively Inert Triacylglycerols Results In Perturbation Of Bioactive Lipid Metabolism In Cells. In Particular, Aberrant Generation Of Bioactive Sphingolipids Is Implicated In A Multitude Of Pathological Outcomes Of Metabolic Disease Including Insulin Resistance, Inflammation, Cardiomyopathy, And Others. This Volume Addresses Not Only The Fundamentals Of Sphingolipid Metabolism And Analysis, But Also The Roles Of Sphingolipids In These Disease Processes. Sphingolipid metabolism and analysis in metabolic disease / Sarah E. Brice and L. Ashley Cowart Sphingolipids and cardiovascular diseases : lipoprotein metabolism, atherosclerosis and cardiomyopathy / Xian Cheng Jiang, Ira J. Goldberg, and Tae Sik Park Heart sphingolipids in health and disease / Marcin Baranowski and Jan Grski Blood sphingolipids in homeostasis and pathobiology / Samar M. Hammad Adipose tissue and ceramide biosynthesis in the pathogenesis of obesity / Fahumiya Samad ... [et al.] Sphingolipids and hepatic steatosis / Benjamin T. Bikman and Scott A. Summers Glycosphingolipids and insulin resistance / Johannes M. Aerts ... [et al.] Glycosphingolipids and kidney disease / Andrew R. Mather and Leah J. Siskind Sphingolipid synthetic pathways are major regulators of lipid homeostasis / Tilla S. Worgall. Front Matter....Pages i-xvii Sphingolipid Metabolism and Analysis in Metabolic Disease....Pages 1-17 Sphingolipids and Cardiovascular Diseases: Lipoprotein Metabolism, Atherosclerosis and Cardiomyopathy....Pages 19-39 Heart Sphingolipids in Health and Disease....Pages 41-56 Blood Sphingolipids in Homeostasis and Pathobiology....Pages 57-66 Adipose Tissue and Ceramide Biosynthesis in the Pathogenesis of Obesity....Pages 67-86 Sphingolipids and Hepatic Steatosis....Pages 87-97 Glycosphingolipids and Insulin Resistance....Pages 99-119 Glycosphingolipids and Kidney Disease....Pages 121-138 Sphingolipid Synthetic Pathways are Major Regulators of Lipid Homeostasis....Pages 139-148 Back Matter....Pages 149-152