Special Topics in Carcinogenesis : Symposium of the “Gesellschaft Zur Bekämpfung Der Krebskrankheiten Nordrhein-Westfalen, E.V.” Düsseldorf, 24th–25th March, 1972

Front Matter....Pages I-VIII Welcome and Introduction....Pages 1-1 Molecular Mechanisms in Chemical Carcinogenesis....Pages 2-8 Formation of Carcinogens From Precursors Occurring in the Environment: New Aspects of Nitrosamine — induced Tumorgenesis....Pages 9-15 Intrauterine Induction of Cancer by the Experimental Application of Chemical Substances....Pages 16-20 The Replication of RNA Tumor Viruses....Pages 21-29 Differentiation of Tumor Cells....Pages 30-44 Immunosuppressive Effect of Friend’s Mouse Leukaemia and Anti-Thymocyte Serum on Herpes Simplex Virus Infection in Mice....Pages 45-46 Precancerous Lesions and their Detection and Diagnosis....Pages 47-52 Preinvasive Carcinoma....Pages 53-56 Enzyme Histochemistry of Human Tumors....Pages 57-62 Electron Microscopy of Oncocytomas and Carcinoid Tumors....Pages 63-68 The Histology of Rare Human Tumors and their Relationships to General Tumor Pathology....Pages 69-74 Chromosome Changes in Human Malignant Tumors: An Evaluation....Pages 75-85 Chromosome Alteration in the Course of Serial Transplantations of Experimental Tumors and Aging of Tumor Stemline Cells....Pages 86-93 Early Changes in Ploidy and Cytogenetics of Liver Cells After Diethylnitrosamine Treatment....Pages 94-97 Carcinogenesis in vitro ....Pages 98-102 Induction and Some Characteristics of “Minimal Deviation” and Other Transplantable Rat Hepatomas....Pages 103-114 Carcinogen-induced Cellular Thesaurismoses and Neoplastic Cell Transformation....Pages 115-126 Experimental Intestinal Carcinogenesis and Polyp Development in Rats and Mice....Pages 127-129 Tumor Induction in the Rat Kidney with Different Doses of DEN (Diethylnitrosamine): Frequency, Latency and Morphology of the Tumors....Pages 130-137 Respiratory Infections and the Pathogenesis of Lung Cancer....Pages 138-157 Experimental Tumors of the Nervous System....Pages 158-169 Tumor Organotropy of N-nitrosomethylurea under the Influence of Hormonal Contraceptives....Pages 170-173 Role of Regional Lymph Nodes in Growth and Metastasis Formation of Methylcholanthrene-induced Sarcomas of Golden Hamsters....Pages 174-181 Back Matter....Pages 183-190 E. GRUNDMANN On behalf of the "Gesellschaft zur Bekampfung der Krebskrankheiten Nordrhein Westfalen e. V." I welcome you in Dusseldorf. During these two days problems of oncogenesis have to be discussed. The participants have been selected with the inten tion of giving a review of the various fields which have some bearing on this topic. So you see here biochemists, cytologists, pathologists, immunologists, pharmacologists, virologists, and so on. Only by extensive cooperation of all scientists concerned in this field can this difficult problem of carcinogenesis ever be cleared up. Once the causal relations have been identified, we may have a reliable basis for cancer treat ment. Research on oncogenesis is of great interest, but it is only a part of the worldwide cancer campaign. It is our hope that this symposium will contribute towards helping the cancer patient. He is the center of all our efforts. Keeping this in mind - let us begin! General Problems of Carcinogenesis Molecular Mechanisms in Chemical Carcinogenesis P.N. MAGEE Covalent binding of metabolites of the hepatocarcinogenic azo dye p-dimethyl aminoazobenzene (DAB) to proteins of the livers of rats to which it had been ad ministered was observed by JAMES and ELIZABETH MILLER in 1947. Since then a large amount of work on the interaction of many other chemical carcinogens with cellular macromolecules has been reported