Solid phase peptide synthesis

Под редакцией R.B. Merrifield. — 2nd edition. — Pierce chemical company, 1984. — 176 p. — ISBN 0-935940-03-0 Contents The chemistry of solid phase peptide synthesis Introduction: the solid phase reaction principle The polymer support The peptide-resin link Protection of alpha-amino groups Blocking of side-chain functional groups The deprotection step The neutralization step The coupling reaction Monitoring SPPS Cleavage of peptides from resin Side reactions in SPPS Purification of peptides Problems in handling and use of peptides References for chapter 1 Laboratory techniques in SPPS Starting materials Solid phase synthesis of peptides Purification of peptides Analytical techniques References for chapter 2 Apparatus for solid phase peptide synthesis Manual solid phase synthesis Automatic solid phase synthesis Maintenance of glassware References for chapter 3 Appendices