Smith and Williams' Introduction to the Principles of Drug Design and Action, Fourth Edition

Advances in knowledge and technology have revolutionized the process of drug development, making it possible to design drugs for a given target or disease. Building on the foundation laid by the previous three editions, Smith and Williams’ Introduction to the Principles of Drug Design and Action, Fourth Edition includes the latest information on topics such as gene therapy, computer-aided design, and molecular techniques including proteomics. Using real-world examples that illustrate the principles of drug design, the author explores the discovery of lead compounds and their manipulation in the production of non-toxic, metabolically stable drug candidates that will interact with target receptors in a predicted fashion. See what’s new in the Fourth Edition: Fully updates and expands the contents Coverage of agonists and antagonists of neuro-transmitters Information on the design of stable peptide-like drugs The human genome and its impact on drug discovery and development Advances in therapy and pharmacokinetics Adopting a from-the-bench-to-the-marketplace approach, the book provides a thorough grounding in rational drug design. It emphasizes principles and elucidates a framework for basic drug design into which current and, more importantly, future drugs will fit.

advances In Knowledge And Technology Have Revolutionized The Process Of Drug Development, Making It Possible To Design Drugs For A Given Target Or Disease. Building On The Foundation Laid By The Previous Three Editions, smith And Williams’ Introduction To The Principles Of Drug Design And Action, Fourth Edition Includes The Latest Information On Topics Such As Gene Therapy, Computer-aided Design, And Molecular Techniques Including Proteomics. Using Real-world Examples That Illustrate The Principles Of Drug Design, The Author Explores The Discovery Of Lead Compounds And Their Manipulation In The Production Of Non-toxic, Metabolically Stable Drug Candidates That Will Interact With Target Receptors In A Predicted Fashion.

see What’s New In The Fourth Edition:

fully Updates And Expands The Contents

coverage Of Agonists And Antagonists Of Neuro-transmitters

information On The Design Of Stable Peptide-like Drugs

the Human Genome And Its Impact On Drug Discovery And Development

advances In Therapy And Pharmacokinetics

adopting A From-the-bench-to-the-marketplace Approach, The Book Provides A Thorough Grounding In Rational Drug Design. It Emphasizes Principles And Elucidates A Framework For Basic Drug Design Into Which Current And, More Importantly, Future Drugs Will Fit.

Procsses of drug handling by the body / Mark Gumbleton The design of drug delivery systems / Ian W. Kellaway Fundamental pharmacokinetics / Glyn Taylor Intermolecular forces and molecular modeling / Robin H. Davies Drug chirality and its pharmacological consequences / Andrew J. Hutt Quantitative structure-activity relationships (QSAR) in drug design / John C. Dearden and Mark T.D. Cronin Prodrugs / Andrew W. Lloyd From program sanction to clinical trials: a partial view of the quest for arimidex, a potent, selective inhibitor of aromatase / Philip N. Edwards Design of enzyme inhibitors as drugs / Anjana Patel, H. John Smith, and Torsten Steinmetzer Peptide drug design / David J. Barlow Combinatorial chemistry: a tool for drug discovery / Barrie Kellam Recombinant DNA technology: monoclonal antibodies / Frederick J. Rowell The human genome and its impact on drug discovery and therapy / Frederick J. Rowell The chemotherapy of cancer / David E. Thurston Neurotransmitters, agonists, and antagonists / Robert D.E. Sewell ... [et al.] Design of antibacterial, antifungal, and antiviral agents / Claire Simons and A. Denver Russell Pharmaceutical applications of bioinorganic chemistry / David M. Taylor and David R. Williams. Advances in knowledge and technology have revolutionized the process of drug development. This book includes the information on topics such as gene therapy, computer-aided design, and molecular techniques including proteomics. It emphasizes principles and elucidates a framework for basic drug design. "Adopting a from-the-bench-to-the-marketplace approach, the book provides a thorough grounding in rational drug design. It emphasizes principles and elucidates a framework for basic drug design into which current and, more importantly, future drugs will fit."--BOOK JACKET To be useful as a medicine, a drug must be capable of being delivered to its site of action in a concentration large enough to initiate a pharmacological response.