Small molecular immunomodifiers of microbial origin : fundamentals and clinical studies of bestatin

Small Molecular Immunomodifiers of Microbial Origin: Fundamental and Clinical Studies of Bestatin focuses on the results of experimental and clinical studies suggesting that bestatin and small molecular weight immunity-enhancing agents can contribute to the treatment of cancer and resistant infections. The selection first offers information on the screening, discoveries, and genetics of microbial secondary metabolites and activity of bestatin. Topics include the effect of bestatin on colony formation of murine bone marrow progenitor cells in vitro; antitumor effect of bestatin on murine transplantable tumors; and structures and properties of bestatin, amastatin, forphenicine, and esterastin. The text then examines the effects of bestatin on DNA and RNA metabolism in T-cells and levamisole and bestatin in immunodefficient aged mice. The text examines the influence of bestatin on the lymphoid system in humans, natural killer activity, and bone marrow. The preliminary phase I study of bestatin in lung cancer cases and malignant skin tumors are discussed. Topics include dosage schedule, clinical findings, and changes in immunological parameters. The selection is a vital reference for readers interested in the applications of bestatin in the treatment of cancer and resistant infections. Content: Front Matter, Page iii Copyright, Page iv PREFACE, Pages v-vi, Hamao UMEZAWA SMALL MOLECULAR WEIGHT IMMUNOMODIFIERS PRODUCED BY MICROORGANISMS: THEIR SCREENING AND DISCOVERIES, AND THE GENETICS OF MICROBIAL SECONDARY METABOLITES, Pages 1-16, Hamao UMEZAWA ACTIVITY OF BESTATIN: ENHANCEMENT OF IMMUNE RESPONSES AND ANTITUMOR EFFECT, Pages 17-38, Masaaki ISHIZUKA, Takaaki AOYAGI, Tomio TAKEUCHI, Hamao UMEZAWA EFFECT OF BESTATIN ON DNA AND RNA METABOLISM IN T-CELLS, Pages 39-58, Werner E.G. MÜLLER LEVAMISOLE AND BESTATIN IN IMMUNODEFFICIENT AGED MICE, Pages 59-69, M. BRULEY-ROSSET, I. FLORENTIN, N. KIGER, J. SCHULZ, G. MATHÉ THE INFLUENCE OF BESTATIN ON THE LYMPHOID SYSTEM IN THE HUMAN, Pages 71-99, Henric BLOMGREN, Lars-Erik STRENDER, Folke EDSMYR EFFECT OF BESTATIN ON NATURAL KILLER ACTIVITY, Pages 101-108, Akira AOIKE, Yoshinori TANAKA, Tomohide HOSOKAWA, Nozomi YAMAGUCHI, Keiichi KAWAI EFFECTS OF AN AMINOPEPTIDASE INHIBITOR (BESTATIN) ON HUMAN LYMPHOCYTES I. EFFECT ON POKEWEED MITOGEN-INDUCED IN VITRO IMMUNOGLOBULIN PRODUCTION, Pages 109-118, Tetsuya YAMAKURA, Toshikazu SHIMBO, Junichi YATA EFFECT OF BESTATIN ON BONE MARROW, Pages 119-123, Ikuro KIMURA, Yasunari NAKATA, Seiya TERAO PRELIMINARY PHASE I STUDY OF BESTATIN IN LUNG CANCER CASES, Pages 125-131, Kiyoshi KONNO, Yushi NAKAI, Nobuko KUMANO PHASE I STUDY OF BESTATIN: (I) A CLINICAL STUDY FOR DETERMINATION OF THE OPTIMAL DOSE OF BESTATIN, Pages 133-141, Kazuyoshi SAITO, Hajime MIYASATO, Kimiko TAJIMA, Shigeo IKEDA PHASE I STUDY OF BESTATIN: (II) CLINICAL TRIAL OF BESTATIN IN MALIGNANT SKIN TUMORS, Pages 143-158, Shigeo IKEDA, Hajime MIYASATO, Kazuyoshi SAITO, Hiroko NAKAYAMA, Kimiko TAJIMA PHASE I AND PRELIMINARY PHASE II CLINICAL TRIALS OF BESTATIN, Pages 159-172, Hisashi MAJIMA CLINICAL EXPERIENCES IN THE USE OF BESTATIN IN THE TREATMENT OF LOCALLY ADVANCED CANCERS: CASE REPORT, Pages 173-177, Masazumi ERIGUCHI, Shinsuke MIKAMO, Genshichiro FUJII CLINICAL EXPERIENCE WITH BESTATIN IN HEAD AND NECK CANCER, Pages 179-185, Yukio INUYAMA, Masatoshi HORIUCHI, Naoyuki KOHNO, Seiji MASHINO CLINICAL AND EXPERIMENTAL STUDY OF BESTATIN FOR ESOPHAGEAL CANCER, Pages 187-199, Kaichi ISONO, Shoichi ONODA, Tatsuo ISHIKAWA, Yoshio KOIDE, Hiroshi SATO CLINICAL EFFECT OF BESTATIN ON MALIGNANT TUMORS OF FEMALE GENITAL ORGANS, Pages 201-215, Kiyoshi AKIYA, Kazuhiro OKABE PHARMACOKINETICS AND METABOLISM OF BESTATIN IN HUMANS AND RATS BY GAS CHROMATOGRAPHY-MASS SPECTROMETRY, Pages 217-229, Hiroshi MIYAZAKI APPENDIX - METHODS OF TESTING HUMAN IMMUNE RESPONSES, Pages 231-254, Henric BLOMGREN