Skin Biophysics: From Experimental Characterisation to Advanced Modelling (Studies in Mechanobiology, Tissue Engineering and Biomaterials Book 22)

This book presents state-of-the-art experimental and modelling techniques for skin biophysics that are currently used in academic and industrial research. It also identifies current and future challenges, as well as a growing number of opportunities in this exciting research field. The book covers the basics of skin physiology, biology, microstructural and material properties, and progressively introduces the reader to established experimental characterisation protocols and modelling approaches. Advanced topics in modelling theories and numerical implementation are also presented. The book focusses especially on: 1. Basic physiology, molecular biology, microstructural and material properties of the skin. 2. Experimental characterisation techniques for the skin (including imaging): __in vivo__ and __in vitro__ techniques and combination of those with __in silico__ approaches. 3. State-of-the-art constitutive models of the skin: elastic, anelastic and mechanobiological formulations (e.g. growth, ageing, healing). 4. Applications: mechanics, damage, biological growth, healing, ageing and skin tribology. This book is addressed to postgraduate students in biomedical/mechanical/civil engineering, (bio)physics and applied mathematics, postdoctoral researchers, as well as scientists and engineers working in academia and industry engaged in skin research, particularly, if at the cross-roads of physical experiments, imaging and modelling. The book is also be of interest to clinicians/biologists who wish to learn about the possibilities offered by modern engineering techniques for skin science research and, by so doing, provide them with an incentive to broaden their outlook, engage more widely with the non-clinical research communities and, ultimately, help cross-fertilising new ideas that will lead to better treatment plans and engineering solutions. Front Matter ....Pages i-xiii Human Skin: Composition, Structure and Visualisation Methods (Helen K. Graham, Alexander Eckersley, Matiss Ozols, Kieran T. Mellody, Michael J. Sherratt)....Pages 1-18 Constitutive Modelling of Skin Mechanics (Georges Limbert)....Pages 19-76 Constitutive Modelling of Skin Growth (Adrian Buganza Tepole, Arun K. Gosain)....Pages 77-100 Constitutive Modelling of Wound Healing (Adrian Buganza Tepole)....Pages 101-133 Constitutive Modelling of Skin Ageing (Georges Limbert, Damien Pond, Andrew McBride)....Pages 135-192 Inverse Methods (Johannes Weickenmeier, Edoardo Mazza)....Pages 193-213 Experimental Characterisation: Rich Deformations (Cormac Flynn)....Pages 215-234 Multiscale Characterisation of Skin Mechanics Through In Situ Imaging (Jean-Marc Allain, Barbara Lynch, Marie-Claire Schanne-Klein)....Pages 235-263 Tension Lines of the Skin (Aisling Ní Annaidh, Michel Destrade)....Pages 265-280 Experimental Tribology of Human Skin (Marc A. Masen, Noor Veijgen, Michel Klaassen)....Pages 281-295