Skeel’s Handbook of Cancer Therapy

For more than 30 years, Skeel’s Handbook of Cancer Therapy (formerly Handbook of Cancer Chemotherapy ) has been the resource of choice for current, reliable information on cancer treatment for most adults. The 9th Edition reflects recent significant advances in the systemic treatment of cancer, including innovations in immunotherapy, oncology genomics, and molecular targeted therapy. An invaluable reference for all levels of physicians, nurses, and allied health professionals who provide care to cancer patients, this bestselling guide combines the most current rationale and the details necessary to safely administer pharmacologic therapy, offering a balanced synthesis between science and clinical practice. A new chapter on the Biologic Basis of Molecular Targeted Therapy , as well as a state-of-the-art review of the current development and use of novel immunotherapeutics , bring you up to date with the rationale and use of these newer agents in cancer treatment. Completely updated throughout to reflect current best practices, including primary indications, usual dosage and schedule, special precautions, and expected toxicities for dozens of new drugs and biologic agents. New contributors provide a fresh perspective on timely topics in cancer treatment and care. An updated section on supportive care reflects this essential aspect of the oncology team’s focus. Regularly updated Inkling content keeps you current with drug profiles and new immunotherapy advances. Now with the print edition, enjoy the bundled interactive eBook edition, which can be downloaded to your tablet and smartphone or accessed online and includes features like: Complete content with enhanced navigation Powerful search tools and smart navigation cross-links that pull results from content in the book, your notes, and even the web Cross-linked pages, references, and more for easy navigation Highlighting tool for easier reference of key content throughout the text Ability to take and share notes with friends and colleagues Quick reference tabbing to save your favorite content for future use Title Page......Page 3 Copyright......Page 4 Dedication......Page 5 Contributors......Page 6 Preface......Page 18 Contents......Page 20 1. Biologic and Pharmacologic Basis of Cancer Chemotherapy......Page 23 2. Biologic Basis of Molecular Targeted Therapy......Page 38 3. Principles of Cancer Immunotherapy......Page 81 4. Systematic Assessment of the Patient With Cancer and Consequences of Treatment......Page 96 5. Selection of Treatment for the Patient With Cancer......Page 113 6. Carcinomas of the Head and Neck......Page 119 7. Carcinoma of the Lung......Page 140 8. Carcinomas of the Gastrointestinal Tract......Page 173 9. Carcinomas of the Pancreas, Liver, Gallbladder, and Bile Ducts......Page 211 10. Carcinoma of the Breast......Page 237 11. Gynecologic Cancer......Page 272 12. Urologic and Male Genital Cancers......Page 314 13. Kidney Cancer......Page 335 14. Endocrine Cancers......Page 350 15. Melanomas and Other Cutaneous Malignancies......Page 371 16. Primary and Metastatic Brain Tumors......Page 398 17. Soft-Tissue Sarcomas......Page 419 18. Bone Sarcomas......Page 434 19. Acute Leukemias......Page 449 20. Chronic Leukemias......Page 501 21. Myeloproliferative Neoplasms and Myelodysplastic Syndromes......Page 530 22. Hodgkin Lymphoma......Page 563 23. Non-Hodgkin Lymphoma......Page 577 24. Multiple Myeloma, Other Plasma Cell Disorders, and Primary Amyloidosis......Page 619 25. Metastatic Cancer of Unknown Origin......Page 649 26. Side Effects of Chemotherapy......Page 656 27. Side Effects of Immune Therapy......Page 681 28. Classification, Use, and Toxicity of Clinically Useful Chemotherapy and Molecular Targeted Therapy......Page 691 Index......Page 874 Title Page 3 Copyright 4 Dedication 5 Contributors 6 Preface 18 Contents 20 SECTION I: BASIC PRINCIPLES AND CONSIDERATIONS OF RATIONAL CHEMOTHERAPY AND MOLECULAR TARGETED THERAPY 23 1. Biologic and Pharmacologic Basis of Cancer Chemotherapy 23 2. Biologic Basis of Molecular Targeted Therapy 38 3. Principles of Cancer Immunotherapy 81 4. Systematic Assessment of the Patient With Cancer and Consequences of Treatment 96 5. Selection of Treatment for the Patient With Cancer 113 SECTION II: MEDICAL THERAPIES OF HUMAN CANCER 119 6. Carcinomas of the Head and Neck 119 7. Carcinoma of the Lung 140 8. Carcinomas of the Gastrointestinal Tract 173 9. Carcinomas of the Pancreas, Liver, Gallbladder, and Bile Ducts 211 10. Carcinoma of the Breast 237 11. Gynecologic Cancer 272 12. Urologic and Male Genital Cancers 314 13. Kidney Cancer 335 14. Endocrine Cancers 350 15. Melanomas and Other Cutaneous Malignancies 371 16. Primary and Metastatic Brain Tumors 398 17. Soft-Tissue Sarcomas 419 18. Bone Sarcomas 434 19. Acute Leukemias 449 20. Chronic Leukemias 501 21. Myeloproliferative Neoplasms and Myelodysplastic Syndromes 530 22. Hodgkin Lymphoma 563 23. Non-Hodgkin Lymphoma 577 24. Multiple Myeloma, Other Plasma Cell Disorders, and Primary Amyloidosis 619 25. Metastatic Cancer of Unknown Origin 649 SECTION III: SUPPORTIVE CARE OF PATIENTS WITH CANCER 656 26. Side Effects of Chemotherapy 656 27. Side Effects of Immune Therapy 681 SECTION IV: CHEMOTHERAPEUTIC AND MOLECULAR TARGETED AGENTS AND THEIR USE 691 28. Classification, Use, and Toxicity of Clinically Useful Chemotherapy and Molecular Targeted Therapy 691 Index 874