زیست‌شناسی سیرتوئین در پزشکی: هدف‌گذاری مسیرهای جدید مراقبت در توسعه، پیری و بیماری

Sirtuin Biology in Medicine: Targeting New Avenues of Care in Development, Aging, and Disease provides a fascinating and in-depth analysis of sirtuins in the body during normal physiology as well during disease highlighting the targeting of sirtuin-controlled pathways for the development of innovative, efficacious, and safe therapeutic strategies for multiple disorders in the body that ultimately can affect lifespan extension. Sirtuins are expressed throughout the body, have broad biological effects, and can significantly impact both cellular survival and longevity during acute and long-term illnesses. These histone deacetylases play an intricate role in the pathology, progression, and treatment of several disease entities ranging from neurodegenerative disorders, cardiovascular disease, immune system dysfunction, reproductive dysfunction, endocrine disorders, gastrointestinal disease, drug dependency, and aging-related disorders. Implementing a translational medicine format, this unique reference highlights novel signaling pathways for sirtuins that promote stem cell proliferation, enhance cellular protection, modulate pathways of apoptosis and autophagy, and extend life span. Each chapter is presented with insightful detail that will be of interest and a comprehensive resource to audiences that include scientists, physicians, pharmaceutical industry experts, nutritionists, and students. Chapters are authored by internationally recognized experts who discuss the broad role of sirtuins in health and disease Details the basic and clinical role of sirtuins for the development of new clinical treatments Summarizes the multidiscipline views and publications for the compelling discipline of sirtuins by covering systems throughout the body Serves as an important resource for a broad audience of healthcare providers, scientists, drug developers, and students in both clinical and research settings Dedication Contents List of contributors About the editor Preface Acknowledgment Section I: Sirtuins, neurodegenerative disease, lifespan extension, and aging 1. Novel treatment strategies for neurodegenerative disease with sirtuins • Kenneth Maiese 2. NAD1: a crucial regulator of sirtuin activity in aging • Nady Braidy and Maria Villalva 3. Sirtuins and life span extension • Shin-Hae Lee and Kyung-Jin Min 4. Sirtuins and aging • Brian J. Morris 5. Sirtuins in the biology of aging • Mateusz Wa ̨troba and Dariusz Szukiewicz 6. Sirtuins as regulators and the regulated molecules of exosomes • Qing Han, Yirui Cheng and Weiliang Xia 7. Sirtuins in aging, age-related pathologies and their association with circadian rhythm • Sankarathi Balaiya 8. Sirtuins, mitochondria, and the melatonergic pathway in Alzheimer’s disease • G. Anderson and M. Maes 9. Sirtuins, melatonin, and the relevance of circadian oscillators • Ru ̈diger Hardeland 10. Epigenetic role of sirtuins in neurodegenerative brain disorders • Archita Khanna, Anamika and Surendra Kumar Trigun 11. Sirtuins and stem cell maintenance, proliferation, and differentiation • Ryan A. Denu and Peiman Hematti 12. Sirtuins in mechanistic target of rapamycin complex 1 signaling • J. Burillo, P. Marqués, B. Jiménez, C. González-Blanco, M. Benito and C. Guillén 13. Free-radical redox timer, sirtuins and aging: from chemistry of free radicals to systems theory of reliability • Vitaly K. Koltover and Tatjana A. Skipa 14. Sirtuins, mitochondria, and exercise in health and disease • Anibh M. Das and Partha Dabke Section II: Sirtuins, cardiovascular disease and end-organ disease 15. Scope to develop sirtuins modulators as a therapy to attenuate cardiac complications • Bugga Paramesha and Sanjay K. Banerjee 16. Role of sirtuins in cardiovascular diseases • Venkatraman Ravi, Sneha Mishra and Nagalingam Ravi Sundaresan 17. Targeting sirtuins to modulate energy metabolism in heart disease • Tsunehisa Yamamoto and Ken Shinmura 18. Sirtuin 1 mediates hepatoprotective effects of resveratrol-like compounds in experiment alliver injury • Hassan Farghali, Mighty Kgalalelo Kemelo and Nikolina Kutinová Canová 19. Sirtuins as key players in aging and kidney dysfunction • Luca Perico and Ariela Benigni 20. Role of sirtuins in liver diseases • D. Ezhilarasan and M. Najimi 21. Sirtuins in bone and cartilage biology • Kazuo Yudoh, Naoko Yui, Ko Terauchi, Hajime Kobayashi, Takanori 22. Vitagenes in avian biology: protective functions of sirtuins • Peter F. Surai, Ivan I. Kochish and Vladimir I. Fisinin 23. Sirtuins in hematopoiesis and blood malignancies • Berta N. Vazquez, Irene Fernández-Duran and Alejandro Vaquero Index __Sirtuin Biology in Medicine: Targeting New Avenues of Care in Development, Aging, and Disease__