Silica-coated Magnetic Nanoparticles: An Insight Into Targeted Drug Delivery And Toxicology (springerbriefs In Molecular Science)

This brief offers a comprehensive discussion of magnetic targeted drug delivery of silica-coated nanodevices. Focusing on the latest trend in pharmaceutical applications of these nanodevices, a multidisciplinary overview is displayed, from synthesis and design to pharmacokenetics, biodistribution and toxicology. Chapters include design of silica-coated magnetic nanodevices; techniques for drug loading with features applicable to biological systems; synthesis, characterization and the assessment of biomedical issues with both in vitro and in vivo experiments. Applications in the treatment of different localized diseases are also addressed in order to present the potential use of these nanosystems as global, commercially available therapeutics. Preface 5 Contents 7 Chapter 1: Introduction 9 References 15 Chapter 2: Magnetic Nanoparticles as Drug Delivery Devices 17 2.1 Generalities of Magnetism in Biomedical Applications 18 2.2 Magnetic Nanoparticles: Synthesis of Magnetic Cores 20 2.2.1 Co-precipitation Method 22 2.2.2 High Temperature Thermal Decomposition Method 22 2.2.3 Hydrothermal and Solvothermal Synthesis 23 2.2.4 Sol–Gel Reactions and Polyol Method 23 2.2.5 Microemulsion 23 2.2.6 Sonolysis or Sonochemical Method 24 2.2.7 Microwave-Assisted Synthesis 24 2.2.8 Biosynthesis 24 2.2.9 Other Methods 25 2.3 Description of Coating 25 2.4 Shape and Morphology 29 2.5 Strategies to Target by Magnetism 29 References 32 Chapter 3: Silica: Chemical Properties and Biological Features 35 3.1 Generalities of Silica 35 3.2 Biological Features of Silica 37 3.3 Diet and Silicon 37 3.4 Bioavailability and Absorption of Silicon 38 3.5 Different Types of Silica with Importance in Biomedicine 39 3.5.1 Bioglasses 39 3.5.2 Star Gels 39 3.5.3 Mesoporous Silica 39 3.6 Solid Silica Nanoparticles 42 References 44 Chapter 4: Synthesis of Solid Silica-Coated Magnetic Nanoparticles for Drug Targeting 46 4.1 Stöber Process 47 4.2 Microemulsion Method 49 4.3 Sodium Silicate Hydrolysis Methods 51 4.4 Sonochemical Deposition 52 4.5 Miscelaneous Methods 52 References 53 Chapter 5: Drug Loading and Release for Specific Diseases 57 5.1 Oncological Diseases 60 5.2 Gene and Antibodies Target and Delivery 61 5.3 Other Drugs and Therapies 62 References 63 Chapter 6: Biomedical Features 65 6.1 Pharmacokinetics, Biodistribution Metabolism, and Excretion of Solid Silica Nanoparticles 65 6.2 Magnetic Core: Biodistribution and Elimination of Magnetite Nanoparticles 71 6.3 Magnetic Silica Nanoparticles 73 References 74 Chapter 7: Toxicological Insights 76 7.1 Toxicological Studies in Cell Culture and In Vivo of Solid Silica Nanoparticles 76 7.2 Toxicology of Iron Oxide Magnetic Nanoparticles 81 References 83 Chapter 8: Future Perspectives on Silica-Coated Magnetic Nanoparticles in Biomedicine 85 References 87 Index 89 Front Matter....Pages i-viii Introduction....Pages 1-8 Magnetic Nanoparticles as Drug Delivery Devices....Pages 9-26 Silica: Chemical Properties and Biological Features....Pages 27-37 Synthesis of Solid Silica-Coated Magnetic Nanoparticles for Drug Targeting....Pages 39-49 Drug Loading and Release for Specific Diseases....Pages 51-58 Biomedical Features....Pages 59-69 Toxicological Insights....Pages 71-79 Future Perspectives on Silica-Coated Magnetic Nanoparticles in Biomedicine....Pages 81-84 Back Matter....Pages 85-89