Signaling Networks and Cell Cycle Control: The Molecular Basis of Cancer and Other Diseases (Cancer Drug Discovery and Development)

The recent dramatic expansion of our knowledge about how cell surface receptors transmit signals to the nucleus, together with the identification of key signaling and cell-cycle-regulating molecules, has provided a major opportunity to search for novel targets for therapeutic intervention in many diseases. In Signaling Networks and Cell Cycle Control: The Molecular Basis of Cancer and Other Diseases, leading scientists summarize this knowledge and describe the effort to design and synthesize inhibiting molecules, as well as to evaluate their biochemical and biological activities. They review the relevant cell surface receptors, their ligands, and their downstream pathways. Also examined are the latest findings on the components of novel signaling networks controlling the activity of nuclear transcription factors and cell cycle regulatory molecules. Rich in cutting-edge insights and authoritative critical analysis, Signaling Networks and Cell Cycle Control: The Molecular Basis of Cancer and Other Diseases presents a wealth of information on the emerging principles of the field, as well as an invaluable guide for all experimental and clinical investigators of cell regulation and its rapidly emerging pharmacological opportunities today. Front Matter....Pages i-xiv Integrin Signaling....Pages 1-25 Signal Transduction Through Tyrosine Kinase Growth Factor Receptors....Pages 27-38 Signaling from TGF-β Receptors....Pages 39-51 The Wnt Signal Transduction Pathway....Pages 53-82 Signaling from G-Protein-Coupled Receptors to the Nucleus....Pages 83-98 Proximal Events in T-Cell Activation....Pages 99-111 Signal Transduction from the High Affinity IgE Receptor....Pages 113-134 Signaling Through Fas (CD95, APO-1) and Related Death Receptors....Pages 135-152 Signal Transduction to the Nucleus by MAP Kinase....Pages 153-164 The Regulation of MAP Kinase Pathways by MAP Kinase Phosphatases....Pages 165-182 Control of MAPK Signaling by Ste20- and Ste11-Like Kinases....Pages 183-211 Ras Signaling and Transformation....Pages 213-230 Signaling Pathways Controlled by Rho Family GTP-Binding Proteins....Pages 231-245 PI3-Kinases....Pages 247-266 PI3K-Related Kinases....Pages 267-301 Integrative Signaling Through c-Abl....Pages 303-324 Src....Pages 325-345 Inhibitors of Protein Kinase C and Related Receptors for the Lipophilic Second-Messenger sn-1,2-Diacylglycerol....Pages 347-364 Reactive Oxygen Species in Proliferative Signaling....Pages 365-377 Sphingolipid Metabolites in Signal Transduction....Pages 379-392 The Jak/Stat Signaling Cascade....Pages 393-409 Regulation of Cell Growth and Death by p53....Pages 411-427 Regulation of NF-κB Function....Pages 429-438 Using Protein-Interaction Domains to Manipulate Signaling Pathways....Pages 439-452 Protein Tyrosine Kinase Inhibitors as Novel Therapeutic Agents....Pages 453-465 A Pharmacological Approach to the MAP Kinase Cascade....Pages 467-481 Specific Inhibitors of p38 MAP Kinase....Pages 483-500 Farnesyltransferase Inhibitors....Pages 501-518 Targeted p53 Gene Therapy-Mediated Radiosensitization and Chemosensitization....Pages 519-536 Treatment of p53-Deficient Cancers by Adenovirus E1B-Region Mutants....Pages 537-544 The Cell Cycle Inhibitor p27 as a Prognostic Marker in Human Tumors and a Novel Target for Therapeutic Intervention....Pages 545-556 Chemical Cyclin-Dependent Kinase Inhibitors....Pages 557-567 Back Matter....Pages 568-578 Leading scientists summarize the latest findings on signal transduction and cell cycle regulation and describe the effort to design and synthesize inhibiting molecules, as well as to evaluate their biochemical and biological activities. They review the relevant cell surface receptors, their ligands, and their downstream pathways. Also examined are the latest findings on the components of novel signaling networks controlling the activity of nuclear transcription factors and cell cycle regulatory molecules. Cutting-edge and highly suggestive, Signaling Networks and Cell Cycle Control: The Molecular Basis of Cancer and Other Diseases presents a wealth of information on the emerging principles of the field, as well as an invaluable guide for all experimental and clinical investigators of cell regulation and its rapidly emerging pharmacological opportunities today.