Signaling Mechanisms in Protozoa and Invertebrates (Progress in Molecular and Subcellular Biology (17))

Comparative endocrinology helps to find the roots of homeostatic regulation in organisms. In this context, many years ago a series of experiments were done, which demonstrated the hormonal regula­ tion also on the invertebrate level. The mechanisms are partly similar, partly different, from those found in vertebrates. The new receptor era of mammalian endocrinology stimulated research on invertebrate hormone receptors, and sophisticated methods are applied also to determine hormones. The experiments demonstrated the existence and even similar function of these structures and signaling molecules. However, data on hormones and receptors at the lowest level of metazoan life and the highest level of protozoan life were not at our disposal. About two decades ago, first observations on the presence of hormone receptors reacting to vertebrate hormones in protozoa were made. Since the early 1980s we know that hormone-like molecules similar to those of higher vertebrates are present also in unicellular organisms. The presence of some second messengers in Tetrahymena was recognized. Since then, the research has been extended and many structures - previously believed to be solely vertebrate characteristics, such as opiate receptors, similar to mammalian ones - were found in unicellular organisms. These observations justified the assumption of a complete endocrine system at protozoan level, where - considering the unicellularit- this seemed to be not required. However, it became clear that the roots of endocrine communication date back at least 2 billion years. Front Matter....Pages I-XIII Evolutionary Significance of the Hormone Recognition Capacity in Unicellular Organisms. Development of Hormone Receptors....Pages 1-28 Studies on the Opioid Mechanism in Tetrahymena ....Pages 29-39 Adenylate and Guanylate Cyclases in Tetrahymena ....Pages 40-60 Signal Peptide-Induced Sensory Behavior in Free Ciliates: Bioassays and Cellular Mechanisms....Pages 61-79 Ciliate Pheromones....Pages 80-104 Cell-Surface GPI Expression in Protozoa. The Connection with the PI System....Pages 105-118 Cell Adhesion Proteins in the Nonvertebrate Eukaryotes....Pages 119-157 Animal Lectins as Cell Surface Receptors: Current Status for Invertebrate Species....Pages 158-182 Characterization of the Receptor Protein-Tyrosine Kinase Gene from the Marine Sponge Geodia cydonium ....Pages 183-208 Back Matter....Pages 209-213 The striking similarities between elements of the mammalian endocrine systems and those of protozoans and invertebrates mean that research which is more easily carried out on simpler organisms has considerable significance for the study of endocrinology in higher organisms. Starting with the presence of hormones and development and function of receptors in protozoa, through the second messenger systems, GPI-expression, signal recognition and pheromone function, the authors demonstrate the universality of basic endocrine mechanisms of the living world, as well as the specialities at lower phylogenetic levels. This book is useful not only for physiologists and endocrinologists, protozoologists and invertebrate zoologists, but also for biologists interested in the study or wonder of evolution