Signaling Mechanisms And Gene Expression In The Ovary (serono Symposia Usa)

The latest developments in ovarian physiology are presented in this book. Based on a proceedings from the Ovarian Workshop developed by Dr. A. Rees Midgley and held biennially since 1976, the contributions will be of interest to all those concerned with the ovarian field. The book focuses on the expression of hormonally and non-hormonally controlled genes involved in the functional and morphological differentiation of cells forming the ovary. It also examines the signaling mechanisms by which endogenous and exogenous hormones and cytokines affect ovarian differentiation and steroidogenesis. Front Matter....Pages i-xxix Front Matter....Pages 1-1 The Gonadotropin Receptors: Structural Insights Learned from the Cloning of Their cDNAs....Pages 3-10 Hormonal Regulation of Gonadotropin Gene Expression....Pages 11-22 Front Matter....Pages 23-23 Inositol Lipid Metabolism and Calcium Signaling in Rat Ovarian Cells....Pages 25-38 Interactions Among the cAMP and IP 3 /DAG Intracellular Signaling Systems in Bovine Luteal Cells....Pages 39-53 Variant Diacylglycerol—Dependent Protein Phosphotransferase Activity in Ovarian Tissues....Pages 54-67 Endocrine, Paracrine, and Autocrine Regulators of the Macaque Corpus Luteum....Pages 68-83 Steroid Signaling in the Follicular Paracrine System....Pages 84-96 Front Matter....Pages 97-97 Regulation of Inhibin and Activin Genes in the Rat Ovary....Pages 99-111 mos Proto-Oncogene Product and Cytostatic Factor....Pages 112-128 Regulation of Genes Encoding Steroidogenic Enzymes in the Ovary....Pages 129-136 Oxysterols: Regulation of Biosynthesis and Role in Controlling Cellular Cholesterol Homeostasis in Ovarian Cells....Pages 137-150 Front Matter....Pages 151-151 Leukocyte Chemo-Attraction and Periovulatory Follicular Processes....Pages 153-162 The Role of IL-1 in the Ovary....Pages 163-169 Effects of Bacterial Endotoxin (Lipopolysaccharide) on FSH-Induced Granulosa Cell Activities....Pages 170-177 TNF α: Altering Thecal and Granulosal Cell Steroidogenesis....Pages 178-189 TNF α Modulation of Ovarian Steroidogenesis in the Rat....Pages 190-199 Inflammatory Cells in the Rabbit Corpus Luteum: Relationship to Luteal Involution....Pages 200-204 Front Matter....Pages 205-205 Two Populations of Steroidogenic Cells in the Theca Layer of Chicken Ovarian Follicles....Pages 207-212 Localization of mRNAs That Encode Steroidogenic Enzymes in Bovine Ovaries....Pages 213-217 Fetal Calf Serum: Eliciting Phosphorylation of Ca ++ /Calmodulin-Dependent Protein Kinase II in Cultured Rat Granulosa Cells....Pages 218-224 Front Matter....Pages 205-205 Differential Regulation of Cytosolic-Free Calcium in Ovine Small and Large Luteal Cells: Effects on Secretion of Progesterone....Pages 225-233 Presence of an Endogenous Inhibitor of Protein Kinase C Throughout Pseudopregnancy in the Rat Ovary....Pages 234-239 Effects of Gonadotropins and PGE 2 on Ovarian Adenylate Cyclase in Cellular Membrane from Mature Cyclic Cows....Pages 240-247 Sphingosine Derivatives, Calmodulin Inhibitors, and TMB-8: Inhibitors of Adenylate Cyclase Activity in Rat Luteal Membranes....Pages 248-253 Cadherins and Ovarian Follicular Development....Pages 254-260 Differential Regulation of 3β-HSD and 17β-HSD Expression in Granulosa Cells....Pages 261-267 Pituitary Hormone Regulation of Ovarian 3β-HSD Gene Expression and Activity in the Rat....Pages 268-273 Molecular Cloning of Rat 3β-HSD: Structure of Two Types of cDNAs and Differential Expression of Corresponding mRNAs in the Ovary....Pages 274-279 The Signal Transduction System in Luteotrophic Stimulation of Expression of the 3β-HSD Gene in Porcine Granulosa Cells in Culture....Pages 280-284 Control of 3β-HSD mRNA and Activity During the Estrous Cycle in the Bovine Ovary....Pages 285-290 Expression of IGF-I and IGF-I Receptor Gene in the Corpus Luteum....Pages 291-296 Expression of IGF-I and IGF-I Receptor Gene in Transformed Luteal Cells....Pages 297-303 Relationships of Oocyte Quality and IGF-I in Follicular Fluid During the Estrual Period in Cattle and Effects of Pre-Estrual Progestins....Pages 304-309 Thecal Cell Luteinization In Vitro:Role of Insulin and IGF-I....Pages 310-316 Decreased Ovulation Rate Associated with Increased mRNA for Inhibin α-Subunit in the Domestic Hen....Pages 317-322 Changes in Concentrations of Inhibin α- and β A -Subunit mRNAs During Maturation of Ovulatory Follicles in the Pig....Pages 323-328 Expression of Jun /AP-1 Superfamily Genes and Cell Cycle-Related Genes in Mitotically Active Rat Granulosa Cells....Pages 329-335 Proclactin Regulation and Developmental Expression of a 37,000 M r Protein in the Corpus Luteum....Pages 336-342 Baboon Corpus Luteum Relaxin: Absence of Effect on Luteal Cell Progesterone Production....Pages 343-347 Relaxin Secretion by the Primate Corpus Luteum During Simulated Early Pregnancy in Hyperstimulated Menstrual Cycles....Pages 348-353 Front Matter....Pages 205-205 Physiological Role of Endogenously Derived PGF 2α in Regulation of Corpus Luteum Function in the Rat....Pages 354-361 Expression and Tissue Specificity of an Abundant 32-kDa Protein Found in the Large Luteal Cell of the Pregnant Rat....Pages 362-367 Endometrial Secretory Products: Regulation of Hormonal Responsiveness of Rabbit Luteal Cells In Vitro....Pages 368-373 Baboon Corpus Luteum Oxytocin....Pages 374-379 Inhibitory Effects of In Vivo and In Vitro Treatment of a LHRH Antagonist (Nal-Lys Antide) on Progesterone Levels During Early Pregnancy in the Rat....Pages 380-384 Suppression of Luteal Production of Progesterone In Vitro by GnRH Agonist During Pregnancy....Pages 385-390 Effects of Long-Term Treatment of a GnRH Agonist on Ovarian Function in the Rat....Pages 391-394 Modulation of the Steroidogenesis of Cultured Human Preovulatory Granulosa Cells by LHRH Analogs....Pages 395-399 Regulation of Ovarian Steroidogenesis in the Little Skate (Raja erinacea) ....Pages 400-404 Localization of Specific GnRH Receptors on Porcine Granulosa Cells and Mast Cells Within Ovarian Follicles....Pages 405-410 In Vitro Increase in Secretion of Oxytocin by Bovine Granulosa Cells After LH Surge....Pages 411-416 LH Stimulation of Ovarian Thecal-Interstitial Cell Differentiation: Sensitizing Effect of Angiotensin II....Pages 417-422 Influence of Lipoproteins on the Synthesis of Apo E by Rat Ovarian Granulosa Cells....Pages 423-427 Bovine Granulosa Cells Steroidogenesis In Vitro, I: Response to Androgens and Estrogens....Pages 428-434 Bovine Granulosa Cells Steroidogenesis In Vitro, II: Response to FSH, Forskolin, and IBMX....Pages 435-440 Sustained Estradiol Production by Porcine Granulosa Cells In Vitro....Pages 441-446 Initiation of Oocyte Maturation by Multiple Kinase Pathways....Pages 447-452 Effects of TNF α and Prolactin: Increased hCG Binding in Human Granulosa Cells; Differential Interaction with hCG-Stimulated Progesterone Secretion....Pages 453-458 Follicular Progesterone Production Stimulated by TNF α Is Modulated by PKC and Calcium....Pages 459-466 Flow Cytometric Analysis of Class I and II MHC Antigens on Ovine Luteal Cell Types....Pages 467-472 Front Matter....Pages 205-205 Thymulin (Serum Thymic Factor) Modulation of Porcine Granulosa Cell Responsiveness to Gonadotropins In Vitro....Pages 473-478 Back Matter....Pages 479-487 Proceedings of the Eighth Ovarian Workshop on Regulatory Processes and Gene Expression in the Ovary, sponsored by Serono Symposia, USA, held July 12 to 14, 1990 in Maryville, Tennessee