Signaling by Toll-Like Receptors (Methods in Signal Transduction Series)

the Discovery Of Toll-like Receptors (tlrs) Spurred The Field Of Innate Immunity Into A Renaissance After Many Years Of Neglect. Since Then, Tlr Research Has Grown At An Exponential Rate. Taking An Integrated Methodological Approach, signaling By Toll-like Receptors Offers A Comprehensive Review Of Important Techniques In Molecular Biology, Cell Biology, Biochemistry, Genetics, And Immunology And Their Critical Application To The Study Of Toll-like Receptor Structure, Biological Function, And The Intracellular Signaling Triggered By These Receptors. Assessing the response of cells to TLR stimulation / Kiyoshi Takeda, Masahiro Yamamoto, and Kenya Honda TLR ligands in experimental settings their purity and specificity / Min-Fu Tsan Analysis of TLR expression, regulation, and signaling / Hui Xiao, Xiaoxia Li, and Derek W. Abbott Intracellular trafficking of toll-like receptors / Harald Husebye ... [et al.] The role of small RhoGTPases in TLR signaling / Monica Ruse and Ulla G. Knaus Use of engineered [beta]-lactamase fragment complementation to detect the associations of toll-like receptors and signaling adaptors / Hyun-Ku Lee and Peter S. Tobias Use of toll-like receptor chimeras to dissect mechanisms of receptor localization and signaling / Tadashi Nishiya and Anthony L. DeFranco Engagement of toll-like receptors modulates chemokine receptor signaling / Chong-Shan Shi and John H. Kehrl Role of toll-like receptor signaling in central nervous system infections / Tammy Kielian The influence of injury on toll-like receptor responses / Thomas J. Murphy ... [et al.]. "Taking an integrated methodological approach, Signaling by Toll-Like Receptors offers a comprehensive review of important techniques in molecular biology, cell biology, biochemistry, genetics, and immunology and their critical application to the study of toll-like receptor structure, biological function, and the intracellular signaling triggered by these receptors. Highlighting the promise of TLR research for uncovering effective pharmaceutical targets, the book presents a combination of theoretical and practical information for understanding and studying TLRs."--Jacket Presents a review of important techniques in molecular biology, cell biology, biochemistry, genetics, and immunology and their critical application to the study of toll-like receptor structure, biological function, and the intracellular signaling triggered by these receptors, as well as the promise for uncovering effective pharmaceutical targets.